DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr4 and LRIT3

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_940908.3	Gene:	LRIT3 / 345193	HGNCID:	24783	Length:	679	Species:	Homo sapiens

Alignment Length:	305	Identity:	64/305 - (20%)
Similarity:	103/305 - (33%)	Gaps:	115/305 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 IRKRDLH---ILTV--GILTY--------TNDQRFQSLHSEGSDEWTLRISSPQP---------- 121
            :|..|||   |.:|  ..|.|        .:..|..:|..:..:.||..:|:|..
Human   131 LRTLDLHNNKITSVPNEALRYLKNLAYLDLSSNRLTTLPPDFLESWTHLVSTPSGVLDLSPSRII 195

  Fly   122 ---RDSGTY-ECQVS----------------------TEPKISQG-----------FRLNVVVSR 149
               :|:..: :|.:|                      :||:...|           .:.:|:.|.
Human   196 LGLQDNPWFCDCHISKMIELSKVVDPAIVLLDPLMTCSEPERLTGILFQRAELEHCLKPSVMTSA 260

  Fly   150 AKILGNAELFIKSGSDINLTCLAMQSPVPPSFIYWYKG-KRVMNYSQRGGINVITERSTRTSKLL 213
            .||:.      ..||::.|.|.|...|.|.  |.|.:. ...:||:.   |....|...|.|.:.
Human   261 TKIMS------ALGSNVLLRCDATGFPTPQ--ITWTRSDSSPVNYTV---IQESPEEGVRWSIMS 314

  Fly   214 IAKATPADSGNYTCSP---SSSDSASVVVHVI--------------NGEHPA-AMQHGNS----- 255
            :...:..|:|:|.|..   :....|.|.|.|:              .|:||. .:|.|:.
Human   315 LTGISSKDAGDYKCKAKNLAGMSEAVVTVTVLGITTTPIPPDTSERTGDHPEWDVQPGSGRSTSV 379

  Fly   256 ------------------SATCLRPLSSTSVPFVLATWMSMTVAS 282
                              ||:.|.|.|:.|  |.|:.:.|.||:|
Human   380 SSASSYLWSSSFSPTSSFSASTLSPPSTAS--FSLSPFSSSTVSS 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	20/125 (16%)
		IG_like	53..145	CDD:214653	20/124 (16%)
		ig	153..227	CDD:278476	18/74 (24%)
		IG_like	161..>227	CDD:214653	18/66 (27%)
LRIT3	NP_940908.3	LRR 1	56..79
		leucine-rich repeat	59..82	CDD:275378
		LRR_8	61..117	CDD:290566
		LRR 2	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3	104..128
		LRR_8	105..165	CDD:290566	8/33 (24%)
		LRR_4	105..146	CDD:289563	6/14 (43%)
		leucine-rich repeat	107..130	CDD:275378
		LRR 4	129..151		7/19 (37%)
		LRR_4	131..170	CDD:289563	10/38 (26%)
		leucine-rich repeat	131..154	CDD:275378	8/22 (36%)
		LRR 5	152..175		2/22 (9%)
		leucine-rich repeat	155..168	CDD:275378	1/12 (8%)
		Ig	267..345	CDD:299845	22/82 (27%)
		IG_like	267..345	CDD:214653	22/82 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..375		5/23 (22%)
		FN3	486..550	CDD:214495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900