DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and itgb4

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	XP_005166847.1	Gene:	itgb4 / 335269	ZFINID:	ZDB-GENE-030131-7209	Length:	1931	Species:	Danio rerio

Alignment Length:	210	Identity:	42/210 - (20%)
Similarity:	77/210 - (36%)	Gaps:	79/210 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 DLHILTVGILTYTND------------QRFQSLHSEGSDEWTL-------RISSPQP--RDSGTY 127
            ||:||    :.::|.            ::...|..:.||::|:       :::.||.  |.:...
Zfish   129 DLYIL----MDFSNSMSDDLDNLKRMGEKLARLVGDLSDDYTIGFGKFVDKVTEPQTDMRPAKLA 189

  Fly   128 ECQVSTEPKISQGFRLNVV------------VSRAKILGNAELFIKSGSDINLTCLAMQSPVPPS 180
            |...:::|..|  || ||:            :.:.:|.||.:. .:.|.|     ..:|:.|...
Zfish   190 EPWSNSDPPFS--FR-NVIKLTSNITSFRQKLQKERISGNLDA-PEGGFD-----AILQTAVCQD 245

  Fly   181 FIYWYKG---------KRVMNYSQRGGINV---ITERSTRTSKLLIAKATPADSGNYTCSPSSSD 233
            .|.|.|.         :...:| :..|.||   |.:|:.....|.:       .||||
Zfish   246 QIGWRKDSTHLLVFSTESAFHY-EADGANVLAGILDRNDEQCHLNV-------DGNYT------- 295

  Fly   234 SASVVVHVINGEHPA 248
                  |.:..::|:
Zfish   296 ------HDVRQDYPS 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	18/82 (22%)
		IG_like	53..145	CDD:214653	17/81 (21%)
		ig	153..227	CDD:278476	19/85 (22%)
		IG_like	161..>227	CDD:214653	17/77 (22%)
itgb4	XP_005166847.1	Integrin_beta	37..457	CDD:278776	42/210 (20%)
		EGF_2	<468..490	CDD:285248
		EGF_2	545..573	CDD:285248
		Integrin_B_tail	625..709	CDD:285239
		Calx-beta	991..1064	CDD:295344
		FN3	1242..1326	CDD:238020
		FN3	1331..1420	CDD:238020
		fn3	1640..1720	CDD:278470
		fn3	1751..1835	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900