DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment dpr4 and Negr1

DIOPT Version :9

Sequence 1:NP_001014616.2 Gene:dpr4 / 3346160 FlyBaseID:FBgn0053512 Length:323 Species:Drosophila melanogaster
Sequence 2:XP_036019026.1 Gene:Negr1 / 320840 MGIID:2444846 Length:362 Species:Mus musculus


Alignment Length:374 Identity:82/374 - (21%)
Similarity:130/374 - (34%) Gaps:136/374 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 CLVPLWL---LLFLDCGMVGGEVPPHYWETPYSQPYFDNSSRREVTATVGQAALLHCRVRNLGDR 75
            |....||   ||.|...:..|:.....|..      .||...|:     |..|:|.|.:.: |..
Mouse     9 CCSNQWLAAVLLSLCSCLPAGQSVDFPWAA------VDNMLVRK-----GDTAVLRCYLED-GAS 61

  Fly    76 AVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSPQPRDSGTYECQVSTE--PKIS 138
            ..:|:.:..  |:..|...::.|.|. |:.:....:::|:|.:....|.|.|.|.|.|:  |:..
Mouse    62 KGAWLNRSS--IIFAGGDKWSVDPRV-SISTLNKRDYSLQIQNVDVTDDGPYTCSVQTQHTPRTM 123

  Fly   139 QGFRLNVVVSRAKI--LGNAELFIKSGSDINLTCLAMQSP------------------------- 176
            | ..|.|.|. .||  :.| ::.|..|:::.|||||...|                         
Mouse   124 Q-VHLTVQVP-PKIYDISN-DMTINEGTNVTLTCLATGKPEPVISWRHISPSAKPFENGQYLDIY 185

  Fly   177 ----------------------------------------------------------VPPSFIY 183
                                                                      |||....
Mouse   186 GITRDQAGEYECSAENDVSFPDVKKVRVIVNFAPTIQEIKSGTVTPGRSGLIRCEGAGVPPPAFE 250

  Fly   184 WYKG-KRVMNYSQRGGINVITERSTRTSKLLIAKATPADSGNYTCSPSS---SDSASVVVHVI-- 242
            |||| ||:.|..|  || :|...||| |.|.:...|....|||||..::   :.:||:.::.|  
Mouse   251 WYKGEKRLFNGQQ--GI-IIQNFSTR-SILTVTNVTQEHFGNYTCVAANKLGTTNASLPLNQIIE 311

  Fly   243 -------NGEHPAAMQHGNSSATCLRPLSSTSVPFVLATW-MSMTVASV 283
                   ....|:..|:|.:.:.|          .:.:.| :::|::||
Mouse   312 PTTSSPVTSPAPSTAQYGITGSAC----------DLFSCWSLALTLSSV 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr4NP_001014616.2 V-set 53..146 CDD:284989 23/94 (24%)
IG_like 53..145 CDD:214653 23/93 (25%)
ig 153..227 CDD:278476 32/157 (20%)
IG_like 161..>227 CDD:214653 30/149 (20%)
Negr1XP_036019026.1 FR1 38..55 CDD:409353 6/27 (22%)
Ig strand A' 40..46 CDD:409353 2/5 (40%)
IG_like 41..129 CDD:214653 24/97 (25%)
Ig strand B 48..56 CDD:409353 3/7 (43%)
CDR1 56..60 CDD:409353 0/4 (0%)
FR2 61..68 CDD:409353 1/6 (17%)
Ig strand C 61..67 CDD:409353 1/5 (20%)
CDR2 69..79 CDD:409353 2/11 (18%)
Ig strand C' 71..74 CDD:409353 1/2 (50%)
Ig strand C' 76..79 CDD:409353 0/2 (0%)
FR3 80..115 CDD:409353 9/35 (26%)
Ig strand D 84..91 CDD:409353 2/7 (29%)
Ig strand E 94..100 CDD:409353 1/5 (20%)
Ig strand F 107..115 CDD:409353 3/7 (43%)
CDR3 116..120 CDD:409353 1/3 (33%)
Ig strand G 120..129 CDD:409353 3/9 (33%)
FR4 122..129 CDD:409353 2/7 (29%)
Ig strand A' 139..144 CDD:409353 1/5 (20%)
IGc2 146..204 CDD:197706 7/57 (12%)
Ig strand B 150..157 CDD:409353 4/6 (67%)
Ig strand C 163..168 CDD:409353 0/4 (0%)
Ig strand C' 170..172 CDD:409353 0/1 (0%)
Ig strand E 180..186 CDD:409353 0/5 (0%)
Ig strand F 193..200 CDD:409353 0/6 (0%)
Ig_3 219..295 CDD:404760 25/79 (32%)
putative Ig strand A 219..225 CDD:409353 0/5 (0%)
Ig strand B 235..239 CDD:409353 0/3 (0%)
Ig strand C 248..252 CDD:409353 0/3 (0%)
Ig strand E 274..278 CDD:409353 2/3 (67%)
Ig strand F 288..293 CDD:409353 4/4 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

Return to query results.
Submit another query.