DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and Igsf9

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001100667.1	Gene:	Igsf9 / 304982	RGDID:	1304566	Length:	1179	Species:	Rattus norvegicus

Alignment Length:	278	Identity:	63/278 - (22%)
Similarity:	110/278 - (39%)	Gaps:	67/278 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DNSSRREVTATVGQA---ALLHCRVRNLGDR----AVSWIRKRDL--HILTVGILT------YTN 97
            |...:.||.:.||:|   |:|.|.:.....|    .:.|:|...|  ..:..|:.:      |..
  Rat    19 DGRRKPEVVSVVGRAGESAVLGCDLLPPAGRPPLHVIEWLRFGFLLPIFIQFGLYSPRIDPDYVG 83

  Fly    98 DQRFQ---SLHSEGSDEWTLRISSPQPRDSGTYECQV------STEPKISQGFRLNVVVSRAKIL 153
            ..|.|   ||..||     ||:     .|.|.|||:|      |.|...:.|..:::.|:.....
  Rat    84 RVRLQTGASLQIEG-----LRV-----EDQGWYECRVLFLDQHSPEQDFANGSWVHLTVNSPPQF 138

  Fly   154 GNAE---LFIKSGSDINLTCLAMQSPVPPSFIYW-YKGKRVMNYSQRGGINVITERSTRTSKLLI 214
            ....   |.:|....:.|.|:|:.||.|  ::.| ::|:.:  ...:|.:.|      |...|.|
  Rat   139 QETPPLVLEVKELEAVTLRCVALGSPQP--YVTWKFRGQDL--GKGQGQVQV------RNGTLWI 193

  Fly   215 AKATPADSGNYTCSPSSSDSASVVVH----VINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATW 275
            .:.....:|:|||..||::.:  |.|    ::.|.....:...|::....:.
  Rat   194 RRVERGSAGDYTCQASSTEGS--VTHTTQLLVLGPPVIVVPPNNNTVNASQD------------- 243

  Fly   276 MSMTVASVAWNSNLNINW 293
            :|:...:.|:.:||..:|
  Rat   244 VSLACRAEAYPANLTYSW 261

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	31/116 (27%)
		IG_like	53..145	CDD:214653	31/115 (27%)
		ig	153..227	CDD:278476	17/77 (22%)
		IG_like	161..>227	CDD:214653	16/66 (24%)
Igsf9	NP_001100667.1	IG	28..110	CDD:214652	25/91 (27%)
		Ig strand A	136..139	CDD:409353	0/2 (0%)
		IG_like	143..223	CDD:214653	23/91 (25%)
		Ig strand A'	145..148	CDD:409353	1/2 (50%)
		Ig strand B	154..161	CDD:409353	2/6 (33%)
		Ig strand C	167..172	CDD:409353	1/4 (25%)
		Ig strand C'	175..177	CDD:409353	0/1 (0%)
		Ig strand D	183..187	CDD:409353	1/9 (11%)
		Ig strand E	189..193	CDD:409353	1/3 (33%)
		Ig strand F	202..210	CDD:409353	4/7 (57%)
		Ig strand G	213..223	CDD:409353	2/11 (18%)
		Ig_3	226..305	CDD:404760	6/49 (12%)
		putative Ig strand A	226..230	CDD:409353	0/3 (0%)
		putative Ig strand A'	235..239	CDD:409353	1/3 (33%)
		putative Ig strand B	241..251	CDD:409353	1/22 (5%)
		putative Ig strand C'	267..270	CDD:409353
		putative Ig strand D	279..282	CDD:409353
		putative Ig strand E	284..290	CDD:409353
		putative Ig strand F	297..305	CDD:409353
		putative Ig strand G	310..319	CDD:409353
		Ig	322..407	CDD:416386
		Ig strand A'	324..328	CDD:409353
		Ig strand B	333..347	CDD:409353
		Ig strand C	353..359	CDD:409353
		Ig strand C'	362..364	CDD:409353
		Ig strand D	371..374	CDD:409353
		Ig strand E	378..382	CDD:409353
		Ig strand F	391..399	CDD:409353
		Ig	418..503	CDD:416386
		Ig strand A	418..421	CDD:409353
		Ig strand A'	427..430	CDD:409353
		Ig strand B	436..443	CDD:409353
		Ig strand C	449..454	CDD:409353
		Ig strand C'	457..459	CDD:409353
		Ig strand D	462..466	CDD:409353
		Ig strand E	469..473	CDD:409353
		Ig strand F	482..490	CDD:409353
		Ig strand G	493..503	CDD:409353
		FN3	508..599	CDD:238020
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	766..807
		PHA03247	<777..1062	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..895
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	942..979
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900