DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and LRIT1

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_056428.1	Gene:	LRIT1 / 26103	HGNCID:	23404	Length:	623	Species:	Homo sapiens

Alignment Length:	310	Identity:	57/310 - (18%)
Similarity:	102/310 - (32%)	Gaps:	65/310 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WTTDCPRALKAICLVPLWL--LLFLD-----------CGMVGGEVPPHYWETPYSQPYFDNSSRR 53
            |..|| |....:.|:..|.  |.|::           .|:...::.....:.|...|     ...
Human   203 WACDC-RLYDLVHLLDGWAPNLAFIETELRCASPRSLAGVAFSQLELRKCQGPELHP-----GVA 261

  Fly    54 EVTATVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWT-LRIS 117
            .:.:.:|..|||.|....:....:||.|.....:         |....|.:.|:|: .|| |.:.
Human   262 SIRSLLGGTALLRCGATGVPGPEMSWRRANGRPL---------NGTVHQEVSSDGT-SWTLLGLP 316

  Fly   118 SPQPRDSGTYECQ--------------VSTEPKISQGFRLNVVVSRAKILG-------NAELFIK 161
            :....|||.|.||              :.|||..|.....:.....|:..|       |.:|..:
Human   317 AVSHLDSGDYICQAKNFLGASETVISLIVTEPPTSTEHSGSPGALWARTGGGGEAAAYNNKLVAR 381

  Fly   162 SGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKATPADSGNY- 225
            ....|....:....|..||    .|.:..:.:.|...:..:::.....|:..:.::.......|
Human   382 HVPQIPKPAVLATGPSVPS----TKEELTLEHFQMDALGELSDGRAGPSEARMVRSVKVVGDTYH 442

  Fly   226 ------TCSPSSSDSASVVVHVINGEHP---AAMQHGNSSATCLRPLSST 266
                  ....:.:.:|..|::.:.|:|.   ..:|.|.:..|....|..|
Human   443 SVSLVWKAPQAKNTTAFSVLYAVFGQHSMRRVIVQPGKTRVTITGLLPKT 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	25/107 (23%)
		IG_like	53..145	CDD:214653	25/106 (24%)
		ig	153..227	CDD:278476	11/87 (13%)
		IG_like	161..>227	CDD:214653	8/72 (11%)
LRIT1	NP_056428.1	LRR 1	60..81
		leucine-rich repeat	61..84	CDD:275378
		LRR_8	63..143	CDD:290566
		LRR 2	84..105
		leucine-rich repeat	85..132	CDD:275378
		LRR 3	108..129
		LRR_8	131..202	CDD:290566
		LRR_4	131..171	CDD:289563
		LRR 4	132..153
		leucine-rich repeat	133..156	CDD:275378
		LRR 5	156..177
		leucine-rich repeat	157..180	CDD:275378
		leucine-rich repeat	181..205	CDD:275378	1/1 (100%)
		TPKR_C2	201..>240	CDD:301599	8/37 (22%)
		Ig	267..345	CDD:299845	21/87 (24%)
		IG_like	267..345	CDD:214653	21/87 (24%)
		FN3	431..498	CDD:214495	10/62 (16%)
		LRR 6. /evidence=ECO:0000305	571..594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900