DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and Lrit3

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001274153.1	Gene:	Lrit3 / 242235	MGIID:	2685267	Length:	681	Species:	Mus musculus

Alignment Length:	305	Identity:	63/305 - (20%)
Similarity:	105/305 - (34%)	Gaps:	110/305 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 RVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSPQ------PR---- 122
            |:.::.:.||.::  |:|..|.:      :..|..:|..:..|.|:....:|.      ||
Mouse   140 RIASVPNEAVRYL--RNLTCLDL------SSNRLTTLPPDFLDSWSHLAVTPSRSPDFPPRRIIL 196

  Fly   123 ---DSGTY-ECQVS----------------------TEPKISQG-----------FRLNVVVSRA 150
               |:..: :|.:|                      :||:..||           .:.:|::|..
Mouse   197 GLQDNPWFCDCHISKVIELSKVTDHAVVLLDPLMVCSEPERFQGILFQRVELEKCLKPSVMMSAT 261

  Fly   151 KILGNAELFIKSGSDINLTCLAMQSPVPPSFIYWYKGK-RVMNYSQRGGINVITE---RSTRTSK 211
            ||..      ..||::.|.|.|...|.|.  :.|.:.. ..:||:      ||.|   ...|.|.
Mouse   262 KITS------ALGSNVLLRCDAKGHPTPQ--LTWTRSDGSTVNYT------VIQESPGEGIRWSI 312

  Fly   212 LLIAKATPADSGNYTCSP---SSSDSASVVVHVING-------------------EHPAAMQHGN 254
            :.:...:..|:|:|.|..   :....|.|.|.|:.|                   :||.....|:
Mouse   313 ISLTSISHKDAGDYRCKAKNLAGISEAVVTVTVVGGVTTTLSPDSSERSPGEPPEQHPQPGLGGS 377

  Fly   255 S--SATCLRPLSSTSVPFVLATWMSMTVASVAWNSNLNINWNWSP 297
            :  |.:.|.| ..||.|       |....|.|..::     .|||
Mouse   378 TPPSKSWLSP-GLTSAP-------SYPTPSAALYTS-----TWSP 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	20/124 (16%)
		IG_like	53..145	CDD:214653	20/123 (16%)
		ig	153..227	CDD:278476	18/77 (23%)
		IG_like	161..>227	CDD:214653	18/69 (26%)
Lrit3	NP_001274153.1	LRR 1. /evidence=ECO:0000255	56..79
		LRR_8	61..117	CDD:290566
		LRR 2. /evidence=ECO:0000255	80..103
		leucine-rich repeat	83..106	CDD:275378
		LRR 3. /evidence=ECO:0000255	104..128
		LRR_8	105..165	CDD:290566	6/32 (19%)
		LRR_4	106..146	CDD:289563	1/5 (20%)
		leucine-rich repeat	107..130	CDD:275378
		LRR_4	129..170	CDD:289563	8/37 (22%)
		LRR 4. /evidence=ECO:0000255	129..151		3/10 (30%)
		leucine-rich repeat	131..154	CDD:275378	3/15 (20%)
		LRR 5. /evidence=ECO:0000255	152..175		5/30 (17%)
		leucine-rich repeat	155..168	CDD:275378	3/18 (17%)
		Ig	254..335	CDD:299845	23/94 (24%)
		IG_like	263..339	CDD:214653	20/89 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	350..391		6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..464
		FN3	489..563	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900