DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr4 and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	310	Identity:	69/310 - (22%)
Similarity:	120/310 - (38%)	Gaps:	90/310 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 WLLLFLDCGMVGGEVPPHYWETPYSQPYFDNSSRREVTATVGQAALLHCRVRNLGDRAVSWIRKR 83
            |:.|.::       .||.:.|||   |.:       :.|..|.:..:.|.........|:|:::.
Human   130 WVHLTIN-------APPTFTETP---PQY-------IEAKEGGSITMTCTAFGNPKPIVTWLKEG 177

  Fly    84 DLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSPQPRDSGTYECQ--------VSTEPKISQG 140
            .|    :|.     ..::|.  |:||    |.::|....|.|.|.|:        |.|...:.||
Human   178 TL----LGA-----SGKYQV--SDGS----LTVTSVSREDRGAYTCRAYSIQGEAVHTTHLLVQG 227

  Fly   141 --FRLNVVVSRAKILGNAELFIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRG---GIN 200
              |    :||..:     .:.:....|..|||.|...|...::.::::.:.|  |.|..   .:.
Human   228 PPF----IVSPPE-----NITVNISQDALLTCRAEAYPGNLTYTWYWQDENV--YFQNDLKLRVR 281

  Fly   201 VITERSTRTSKLLIAKATPADSGNYTCSPSS----SDSASVVVHVINGEHPAAMQHGNSSATCLR 261
            ::.:     ..|:|.:..|.|||.|||.||:    |.|||..:.|   ::||.:.:       :.
Human   282 ILID-----GTLIIFRVKPEDSGKYTCVPSNSLGRSPSASAYLTV---QYPARVLN-------MP 331

  Fly   262 PLSSTSVPFVLATWMSMTVAS------VAWNSN-------LNINWNWSPD 298
            |:  ..||..:..::...|.:      |.||.:       .|:.|....|
Human   332 PV--IYVPVGIHGYIRCPVDAEPPATVVKWNKDGRPLQVEKNLGWTLMED 379

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	22/102 (22%)
		IG_like	53..145	CDD:214653	22/101 (22%)
		ig	153..227	CDD:278476	16/76 (21%)
		IG_like	161..>227	CDD:214653	16/68 (24%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653
		Ig	41..115	CDD:143165
		I-set	139..225	CDD:254352	24/110 (22%)
		IGc2	153..210	CDD:197706	16/71 (23%)
		I-set	229..321	CDD:254352	27/107 (25%)
		Ig	235..321	CDD:299845	24/97 (25%)
		IG_like	331..414	CDD:214653	10/51 (20%)
		Ig	<353..414	CDD:299845	6/27 (22%)
		IG_like	426..505	CDD:214653
		Ig	442..505	CDD:299845
		FN3	510..601	CDD:238020
		FN3	617..699	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810