DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr4 and SDK1

DIOPT Version :9

Sequence 1:NP_001014616.2 Gene:dpr4 / 3346160 FlyBaseID:FBgn0053512 Length:323 Species:Drosophila melanogaster
Sequence 2:NP_689957.3 Gene:SDK1 / 221935 HGNCID:19307 Length:2213 Species:Homo sapiens


Alignment Length:304 Identity:86/304 - (28%)
Similarity:127/304 - (41%) Gaps:53/304 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 GGEVPPH-YWETPYSQPYFDNSSRREVTATV--GQAALLHCRVRNLGDRAVSWIRKRDLHILTVG 91
            |||:..| |.:.....|.|   ::|.|..||  |..|:|.|.|......|::|  ||:.|||..|
Human   464 GGEIQTHTYLDVTNIAPVF---TQRPVDTTVTDGMTAILRCEVSGAPKPAITW--KRENHILASG 523

  Fly    92 ILTYTNDQRFQSLHSEGSDEWTLRISSPQPRDSGTYEC-QVSTEPKISQGFRLNVVVSRAKILGN 155
            .:..   .||..|.|.|     |:|:....:|:|.|.| ..:||..::....| .|.:|..|:..
Human   524 SVRI---PRFMLLESGG-----LQIAPVFIQDAGNYTCYAANTEGSLNASATL-TVWNRTSIVHP 579

  Fly   156 AE--LFIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKAT 218
            .|  :.|| |:...|.|.|...|.......|.|....:..|...  .::.|:.   ..|||::..
Human   580 PEDHVVIK-GTTATLHCGATHDPRVSLRYVWKKDNVALTPSSTS--RIVVEKD---GSLLISQTW 638

  Fly   219 PADSGNYTC---SPSSSDSASVVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATWMSMTV 280
            ..|.|:|:|   |...:||....:.||  |.|.:.|:     ..:.|.||.|...|| :|    |
Human   639 SGDIGDYSCEIVSEGGNDSRMARLEVI--ELPHSPQN-----LLVSPNSSHSHAVVL-SW----V 691

  Fly   281 ASVAWNSNL-----NINWNWSPDWRWHWNPKWNWSNLAAGLVGI 319
            .....||.:     .::.|.|| |:.|      .||:...:.|:
Human   692 RPFDGNSPILYYIVELSENNSP-WKVH------LSNVGPEMTGV 728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr4NP_001014616.2 V-set 53..146 CDD:284989 31/95 (33%)
IG_like 53..145 CDD:214653 31/94 (33%)
ig 153..227 CDD:278476 18/75 (24%)
IG_like 161..>227 CDD:214653 16/65 (25%)
SDK1NP_689957.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..73
I-set 104..188 CDD:254352
Ig 122..176 CDD:143165
Ig 219..265 CDD:299845
IGc2 312..364 CDD:197706
I-set 386..475 CDD:254352 5/10 (50%)
Ig 404..472 CDD:143165 4/7 (57%)
I-set 480..570 CDD:254352 33/103 (32%)
Ig 494..570 CDD:299845 27/86 (31%)
I-set 575..664 CDD:254352 23/94 (24%)
Ig 580..664 CDD:299845 22/89 (25%)
FN3 668..759 CDD:238020 20/78 (26%)
fn3 771..857 CDD:278470
FN3 872..967 CDD:238020
FN3 972..1054 CDD:238020
FN3 1070..1166 CDD:238020
FN3 1176..1271 CDD:238020
fn3 1279..1365 CDD:278470
FN3 1378..1471 CDD:238020
FN3 1477..1572 CDD:238020
FN3 1580..1694 CDD:238020
FN3 1704..1797 CDD:238020
FN3 1802..1883 CDD:238020
FN3 1903..1996 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2075..2098
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q6V4S5 2207..2213
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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