DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and Ncam2

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001106679.1	Gene:	Ncam2 / 17968	MGIID:	97282	Length:	837	Species:	Mus musculus

Alignment Length:	270	Identity:	61/270 - (22%)
Similarity:	106/270 - (39%)	Gaps:	56/270 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 REVTA----TVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWT 113
            |||.:    ..|:.|.:.|||.:....||||:...: .:.|:      .|.||..|.:.     .
Mouse   118 REVVSPQEFKQGEDAEVVCRVSSSPAPAVSWLYHNE-EVTTI------PDNRFAVLANN-----N 170

  Fly   114 LRISSPQPRDSGTYECQVSTEPKISQGFRLNVVVSRA--KILGNAELF---IKSGSDINLTCLAM 173
            |:|.:....|.|.|.|:...|.:....||..:|:...  .|:...:.|   .:.|.::.|||.|.
Mouse   171 LQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVNVPPAIMMPQKSFNATAERGEEMTLTCKAS 235

  Fly   174 QSPVPPSFIYWYKGKRVM----NYSQRGGINVITERSTRTSKLLIAKATPADSGNYTCSPSSSDS 234
            .||.|.  |.|::..:::    .|..:|....:|.|:      :|.|    |.|:|.|..::...
Mouse   236 GSPDPT--ISWFRNGKLIEENEKYILKGSNTELTVRN------IINK----DGGSYVCKATNKAG 288

  Fly   235 AS---------VVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATWMSMTVASVAWNSNLN 290
            ..         |..|::..::....::|:.:..|    .:...|....|| ...:..|.::..
Mouse   289 EDQKQAFLQVFVQPHILQLKNETTSENGHVTLVC----EAEGEPVPEITW-KRAIDGVMFSEG-- 346

  Fly   291 INWNWSPDWR 300
               :.|||.|
Mouse   347 ---DKSPDGR 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	26/96 (27%)
		IG_like	53..145	CDD:214653	26/95 (27%)
		ig	153..227	CDD:278476	20/80 (25%)
		IG_like	161..>227	CDD:214653	19/69 (28%)
Ncam2	NP_001106679.1	Ig1_NCAM-2	21..112	CDD:143274
		I-set	22..111	CDD:254352
		I-set	117..193	CDD:254352	24/86 (28%)
		IGc2	128..189	CDD:197706	20/72 (28%)
		Ig	208..301	CDD:299845	22/104 (21%)
		I-set	215..298	CDD:254352	21/94 (22%)
		Ig	300..397	CDD:299845	12/64 (19%)
		IG_like	308..395	CDD:214653	10/56 (18%)
		IG_like	413..491	CDD:214653
		IGc2	414..482	CDD:197706
		FN3	496..588	CDD:238020
		fn3	594..678	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900