DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and rig-4

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_501339.2	Gene:	rig-4 / 177597	WormBaseID:	WBGene00004371	Length:	2325	Species:	Caenorhabditis elegans

Alignment Length:	293	Identity:	62/293 - (21%)
Similarity:	105/293 - (35%)	Gaps:	74/293 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 EVTATVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQ-------RFQSLHSEGSD- 110
            |:..|||.:..|.|.|:......:.|.:...:.....|.||....:       :.::.::.|:|
Worm   332 EIQKTVGSSLSLKCSVKKKSSMDIKWYKNGLMMTTQRGKLTIDRIKQDDFGLYQCEATNAAGADL 396

  Fly   111 -------------------------EWTLRISSPQPRDSGTYECQVSTEPKISQGFRLNVVVSRA 150
                                     |..:.:.:|.||....::...|.|....  |...:..|:.
Worm   397 ASVWVKEGEANETVATEMSEDGMSLEEEISMETPPPRKLKFFDNSKSQEQLFP--FTSELEPSQK 459

  Fly   151 KILGNAELFIKSGSD-INLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERSTRTSKLLI 214
            .|....:|.:.||:| |.:.|.|..|| ||:.|:...|..:...:.:..:.        ...|.|
Worm   460 LIKTPKDLTVASGTDRIMMECAATGSP-PPNIIWLLNGHEIQTDNVKYDLT--------NDGLAI 515

  Fly   215 AKATPADSGNYTCSPSSSDSASVVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATWMSMT 279
            .....:|.|.|||..|.|:..:.....:||:  :.:::|.:..   :.|..|:|.|      |..
Worm   516 HDIRKSDEGEYTCEISGSNVKATANVQVNGD--SLIEYGPADQ---KSLIGTNVEF------SCE 569

  Fly   280 V-------ASVAW-----------NSNLNINWN 294
            |       |||.|           ||.|.|:.|
Worm   570 VAKEYVRKASVEWYLNDVLLPVNGNSGLRISRN 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	20/124 (16%)
		IG_like	53..145	CDD:214653	20/123 (16%)
		ig	153..227	CDD:278476	18/74 (24%)
		IG_like	161..>227	CDD:214653	17/66 (26%)
rig-4	NP_501339.2	IG_like	330..402	CDD:214653	13/69 (19%)
		IGc2	338..393	CDD:197706	8/54 (15%)
		I-set	459..543	CDD:254352	23/92 (25%)
		IGc2	478..534	CDD:197706	16/64 (25%)
		IG_like	553..639	CDD:214653	15/59 (25%)
		Ig	564..635	CDD:143165	13/45 (29%)
		FN3	643..747	CDD:238020
		FN3	756..850	CDD:238020
		FN3	858..954	CDD:238020
		FN3	959..1042	CDD:238020
		FN3	1057..1151	CDD:238020
		FN3	1156..1251	CDD:238020
		FN3	1258..1356	CDD:238020
		FN3	1361..1453	CDD:238020
		FN3	1464..1560	CDD:238020
		FN3	1572..1664	CDD:238020
		FN3	1679..1764	CDD:238020
		FN3	1774..1858	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810