DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and Dscaml1

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001074739.2	Gene:	Dscaml1 / 114873	MGIID:	2150309	Length:	2053	Species:	Mus musculus

Alignment Length:	278	Identity:	72/278 - (25%)
Similarity:	104/278 - (37%)	Gaps:	66/278 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 PYSQPYFDNSSRREVTATVGQAALLHCRVRNLGDR---AVSWIRKRDLHILTVGILTYTNDQRFQ 102
            ||:....|..|.|      |..|:..|.:.:....   .|||  ::|    ||.|   |.:.||
Mouse   126 PYTVRVEDQRSMR------GNVAVFKCLIPSSVQEYVSVVSW--EKD----TVSI---TPENRF- 174

  Fly   103 SLHSEGSDEWTLRISSPQPRDS-GTYEC----QVSTEPKISQGFRLNVVVSRAKILGNAELF--- 159
            .:.|.|.    |.||..|..|: .||.|    :.|.|.:.|.|.||:|......|....:.|
Mouse   175 FITSHGG----LYISDVQKEDALSTYRCITQHKYSGETRQSNGARLSVTDPAESIPTILDGFHSQ 235

  Fly   160 -IKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKATPADSG 223
             :.:|..:.|.|.|...|:|.  |.|.|..|.:....|.        :.|.:.|.|:.....|||
Mouse   236 EVWTGHSVELPCAASGYPIPA--IRWLKDGRPLPADSRW--------AKRITGLTISDLRTEDSG 290

  Fly   224 NYTCSPSSSDSASVVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATWMSMTVASVAWNSN 288
            .|.|..:::..::               ..|...|.:.||..|..|..|.|.:..||.
Mouse   291 TYICEVTNTFGSA---------------EANGILTVIDPLHVTLTPKKLKTGIGSTVI------- 333

  Fly   289 LNINWNWSPDW--RWHWN 304
            |:.....||::  ||:.|
Mouse   334 LSCALTGSPEFTIRWYRN 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	30/100 (30%)
		IG_like	53..145	CDD:214653	30/99 (30%)
		ig	153..227	CDD:278476	19/77 (25%)
		IG_like	161..>227	CDD:214653	18/65 (28%)
Dscaml1	NP_001074739.2	IGc2	43..110	CDD:197706
		Ig	125..218	CDD:353325	34/111 (31%)
		I-set	226..311	CDD:336764	21/109 (19%)
		Ig_3	317..389	CDD:339005	12/42 (29%)
		Ig	408..498	CDD:353325
		IGc2	519..577	CDD:197706
		Ig	615..681	CDD:319273
		Ig_DSCAM	707..785	CDD:143211
		Ig	803..891	CDD:353325
		FN3	887..981	CDD:238020
		FN3	988..1085	CDD:238020
		FN3	1093..1186	CDD:238020
		FN3	1191..1282	CDD:238020
		Ig	1307..1377	CDD:319273
		FN3	1384..1474	CDD:238020
		FN3	1488..1560	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1716..1741
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1773..1803
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1840..1862
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1974..2053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810