DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33521 and MICAL1

DIOPT Version :9

Sequence 1:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001273542.1	Gene:	MICAL1 / 64780	HGNCID:	20619	Length:	1086	Species:	Homo sapiens

Alignment Length:	407	Identity:	74/407 - (18%)
Similarity:	138/407 - (33%)	Gaps:	121/407 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 CHQCKKPVYKMEEVILSLKTATTIFHKTCLRCKDCGKHLKFDSYNVH--DGSLYCSMHFKLIFAP 142
            |..|.:.:|.:|.:.::    ...||::|.||..|...|....|..|  ||..||..|.     |
Human   716 CALCGEHLYVLERLCVN----GHFFHRSCFRCHTCEATLWPGGYEQHPGDGHFYCLQHL-----P 771

  Fly   143 KVVYEEFTPRKAELIIR-----------ENQPIKLPPDVAK-------ASDKPSLGLDELQELNL 189
            :      |..|||...|           ||   .:||.::.       |...|.......:::.|
Human   772 Q------TDHKAEGSDRGPESPELPTPSEN---SMPPGLSTPTASQEGAGPVPDPSQPTRRQIRL 827

  Fly   190 RSKFKVFENGYEEHNNNLRERQDIA---ITHSKSIQ---------STLTK------FHGLGIP-- 234
            .|.                |||.::   :|....::         |.|.:      |.|.|:|
Human   828 SSP----------------ERQRLSSLNLTPDPEMEPPPKPPRSCSALARHALESSFVGWGLPVQ 876

  Fly   235 -NSELTKLDDKNSDNNSDGDGDMNFMCLKKEIER--ETPVGLGEAMNDI---------RSKFEQG 287
             ...|..::.:..::....:.:...:.|..::|:  :|.......||:.         |:|.|:.
Human   877 SPQALVAMEKEEKESPFSSEEEEEDVPLDSDVEQALQTFAKTSGTMNNYPTWRRTLLRRAKEEEM 941

  Fly   288 DLMAKEGRREERKQEI---------QNIRSRLFLGKQAKIKEMY-KLAVAESEQPVTSVGKTPDI 342
            ....|....:.|..||         :.::..|.|.:|:...|.. ||.|.:..|.|..
Human   942 KRFCKAQTIQRRLNEIEAALRELEAEGVKLELALRRQSSSPEQQKKLWVGQLLQLVDK------- 999

  Fly   343 CAIKPTQEIKNRFENGEVYKDSKILSSEVSCGIHEDADVFESGISKASRNIFMKLDANIKSGLSN 407
                         :|..|.::::::.:.....:.|.    :..:.:..|. :|..:.|:|:....
Human  1000 -------------KNSLVAEEAELMITVQELNLEEK----QWQLDQELRG-YMNREENLKTAADR 1046

  Fly   408 HVQYTLPDKKYQIHNQK 424
            ..:..:..|...:.||:
Human  1047 QAEDQVLRKLVDLVNQR 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	17/57 (30%)
MICAL1	NP_001273542.1	NAD_binding_8	108..>135	CDD:290186
		CH	530..626	CDD:278723
		USP19_linker	632..712	CDD:293210
		LIM_Mical_like	716..769	CDD:188744	17/56 (30%)
		DUF3585	946..1079	CDD:288945	23/143 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910