DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33521 and mical3b

DIOPT Version :9

Sequence 1:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_017210768.1	Gene:	mical3b / 566850	ZFINID:	ZDB-GENE-050211-1	Length:	1735	Species:	Danio rerio

Alignment Length:	945	Identity:	149/945 - (15%)
Similarity:	286/945 - (30%)	Gaps:	353/945 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NPQSSKISFGNGLPLKKKKTKKSKTNEYD-----NQNINMKKS---------------------F 43
            ||:..|....:.:..:::.::..::.|.|     |:|.:..::                     .
Zfish   658 NPKDKKEKEADSVGKRRRTSQAGQSEEEDALHDGNENKSPAETPGSEPKASEGHSKVRSMASLLL 722

  Fly    44 TKFDD---------LQKRNVIH----------------VRSRDSKKAQSLFR------STIPEKV 77
            .||::         ::::|.||                ::|:.::..:.|.|      ..:|..|
Zfish   723 AKFEENSPSPSTTAIRRQNYIHMYTGGVSSLALQIANQIQSQQAQAPKLLHRRESGSQKDLPVNV 787

  Fly    78 ---ENCHQCKKPVYKMEEVILSLKTATTIFHKTCLRCKDCGKHLKFDSY---NVHDGSLYCSMHF 136
               :.|:.|.:.||.||.    |......||::|.:|..|...::..:|   .:| |..||..||
Zfish   788 GSSDVCYFCGRRVYVMER----LSAEGKFFHRSCFQCDHCSSTIRLSNYTYDQLH-GKFYCKHHF 847

  Fly   137 KLIF-------------APKVVYEEF--------------------------------------- 149
            ....             ||:......
Zfish   848 SFRLASVAQRKRPAPPVAPRPAQASLAASSASTSLSSLGSVGTATPDSWSSSTHTDMASSLAKRL 912

  Fly   150 --TPRKAEL------IIRENQPIKLPPDVAKASDKPSLGLDE--------LQELNLRSKFKVFEN 198
              ||.:.||      ..:::.|::..|:...|....|..|.|        ..|.:|..:..|::.
Zfish   913 CGTPERIELENYKPSPQKQDSPLQEVPEETLAQHNLSASLQEKNAEEQSSSSESDLEEEELVWKK 977

  Fly   199 GYEEHNNNLRERQDIAITHSKSIQSTLTKFHG-------LGIPNSELTKLDDKNSDNNSDG---- 252
            |.|.|.....||:       ..::..|.:..|       .|....|:::.:....|::.:|
Zfish   978 GEELHARTNGERK-------LDLEEELKEEEGGEKLEKQEGEEEGEVSEEEQDEGDSSDEGEYCP 1035

  Fly   253 ----------------------------DGDMNF-------MCLKKEIERETPVGLGEAMND--I 280
                                        |.|::.       :|.::|.|...|.....|..:  :
Zfish  1036 WERERLSGVWLEEEEAGFVKESYEGCSDDPDIDVSSLSESKLCDQREQEESVPFHQSPASTESPV 1100

  Fly   281 RSKFEQGDLMAKEGRREERKQEIQNIRSRLFLGKQAKIKEMYKLAVAESEQPVTSVGKTP----- 340
            ..|..:.||........|...           .|::::.|.:.:..||..:   |:|.||
Zfish  1101 SMKPSESDLTPDPSTTPESSP-----------AKRSEVVEEFWMKSAEIRK---SLGLTPLSREL 1151

  Fly   341 ---DICAIKPTQEIKNRFENGEVYKDSKILSSEVSCGI-------HEDADVFE----------SG 385
               .|.|...|..:|..|.....|..:.:.|...|..|       |...|:.|          :|
Zfish  1152 QPKHIAASTQTSNVKESFYTSVTYNTAALDSPNQSARICDSSTQTHSVTDLQETSPLGPTDGDAG 1216

  Fly   386 ISKASRNIFMKLDANIK-------SGLSNHVQYT---------LPDKKYQ-------------IH 421
            :.....::..:|...::       .||.:....|         ||...|.             :|
Zfish  1217 VDLGRCSVVHRLSITVEGCVMADNQGLDSTSFATESVLNPDAGLPTPPYSPSHSPLVGKQCRALH 1281

  Fly   422 N---------------------QKVQENSDVEIVKSDSKPEEVKV----ATEELSKKFKFFETYS 461
            :                     |:....||:|..:| ..|:|:::    ..|:|.::....|:..
Zfish  1282 HSEPILDREVMAFSSTCTASVPQRSSFKSDLEQAQS-LPPDEIEILCGDEAEKLPERSCRMESGE 1345

  Fly   462 PAENKKRIFRMTPPR-----------------EGVVMFPPPDSETNQQISTTLFNDNILQKT--- 506
            ....:....|..|.|                 |..:..|..|.:..::..::||:....:|.
Zfish  1346 VDNRRAEHSRTLPDRVVAPLLAGGPEVRLRRSEMKLWGPDADGDVKEKKRSSLFSPRKSRKNGNA 1410

  Fly   507 ---------------KTTSTILNKFREMEEQKM--------SDQQKKK----NPKPLKCFTPPPE 544
                           ||..::..|.::.:|..:        ::..|:|    |.....||...|.
Zfish  1411 AAESGRETGKHKSLWKTVFSVYKKDKKRKEVAVVAETLPAANNGSKRKVSGINRTTDLCFRKNPS 1475

  Fly   545 ISHQFIRSDTEEESDSDYE------QNSENDEESEINPSNSYYNDKALLEAQSVARAKQLRAKFE 603
            .|     .||:....:..|      |.:..:||         .|.:.....|..||.:..:.:..
Zfish  1476 FS-----EDTDMSCHALLERCPLRAQRAGTEEE---------LNARLTRRVQRAARRQAKQEELR 1526

  Fly   604 KWQNNEIEQEIKEGRIDVYSQLISNESIESAKAIR 638
            :....:|.|...| :::|..:.:..:.:...||:|
Zfish  1527 RLHRAQIIQRQLE-QVEVKQRQLEEKGVAVEKALR 1560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	17/58 (29%)
mical3b	XP_017210768.1	FAD_binding_3	86..>140	CDD:332373
		CH	518..613	CDD:306753
		LIM_Mical	793..847	CDD:188823	17/58 (29%)
		DUF3585	1534..1721	CDD:314926	6/28 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910