DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG33521 and LIMA1

DIOPT Version :10

Sequence 1:NP_001014703.1 Gene:CG33521 / 3346141 FlyBaseID:FBgn0250819 Length:663 Species:Drosophila melanogaster
Sequence 2:NP_001107018.1 Gene:LIMA1 / 51474 HGNCID:24636 Length:760 Species:Homo sapiens


Alignment Length:531 Identity:117/531 - (22%)
Similarity:207/531 - (38%) Gaps:128/531 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 SLNPQSSKISFGNGLPLKKKKTKKSKTNEYD--------------------NQNINMKKSFTKFD 47
            :::.|||..::.|.|.....:.|..|..:.:                    |:|....:|....|
Human   277 AVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAED 341

  Fly    48 D--------LQKRNVIHVR--SRDSKKAQSLFRSTIPEKV--------ENCHQCKKPVYKMEEVI 94
            |        .:.:..:|.:  |.|| :|.||..|:.|:.:        |.|.:|:|.||.||.::
Human   342 DSPGDSQVKSEVQQPVHPKPLSPDS-RASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLL 405

  Fly    95 LSLKTATTIFHKTCLRCKDCGKHLKFDSYNVHDGSLYCSMHFKLIFAPKVVYEE---FTPRKAEL 156
            .:.:    :||.:|.||..|...|...:|....|.:||..||..:|..|..|:|   ..|.| :|
Human   406 ANQQ----VFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHK-DL 465

  Fly   157 IIRENQP---IKLPPDVAKASDKP-SLGLDELQELNLRSKFKVFENGYEEHNNNLRERQDIAITH 217
            ...:|:.   ::.|..:|.|.:.| |.|:::..    .:|..|.....|...::.:|::| ....
Human   466 WASKNENEEILERPAQLANARETPHSPGVEDAP----IAKVGVLAASMEAKASSQQEKED-KPAE 525

  Fly   218 SKSIQSTLTKFHGLGIPNSELTK----------LDDKNSDNNSDGDGDMNFMCLKKEI---ERET 269
            :|.::........||...|.|.:          .:|:.|......|.|::...|::..   ||..
Human   526 TKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSR 590

  Fly   270 PVGLGEAMNDIRSK--------FEQGDLMAKE------GRREERKQEIQNIRSRLFLGKQAKIKE 320
            |..:..:......|        ..:|..|:::      ||..|||| ::|               
Human   591 PFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQ-VEN--------------- 639

  Fly   321 MYKLAVAESEQPVTSVGKTPDICAIKPTQEIKNRFENGEVYKDSKILSSEVSCGIHEDADVFESG 385
                  |::.:...:||||       ..|..:::.|.|:..|:...|..|....:...||     
Human   640 ------AKASKKNGNVGKT-------TWQNKESKGETGKRSKEGHSLEMENENLVENGAD----- 686

  Fly   386 ISKASRNIFMKLDA--NIKS-GLSNHVQYTLPDKKYQIHNQKVQENSDVEIVKSDSKPEEVKVAT 447
             |....|.|:|..:  ..|| ..|:.|..|..: ::...|||.|   |||:.:.:...|   ::.
Human   687 -SDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAE-EFTTQNQKSQ---DVELWEGEVVKE---LSV 743

  Fly   448 EELSKKFKFFE 458
            ||..|:.::::
Human   744 EEQIKRNRYYD 754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG33521NP_001014703.1 LIM_Mical_like_2 80..136 CDD:188829 18/55 (33%)
LIMA1NP_001107018.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..131
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 146..182
Required for interaction with NPC1L1. /evidence=ECO:0000250|UniProtKB:Q9ERG0 164..166
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..264
LIM_Eplin_alpha_beta 391..443 CDD:188869 18/55 (33%)
Required for interaction with MYO5B. /evidence=ECO:0000250|UniProtKB:Q9ERG0 494..514 3/23 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..710 45/235 (19%)
Blue background indicates that the domain is not in the aligned region.

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