DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33521 and NRAP

DIOPT Version :9

Sequence 1:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001248392.1	Gene:	NRAP / 4892	HGNCID:	7988	Length:	1731	Species:	Homo sapiens

Alignment Length:	686	Identity:	130/686 - (18%)
Similarity:	226/686 - (32%)	Gaps:	204/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VENCHQCKKPVYKMEEVILSLKTATTIFHKTCLRCKDCGKHLKFDSYNVHDGSLYCSMHFKLIFA 141
            |:.|.:|...||..|::    .....|:||.|..|:.|...|..:::..|....||..|
Human     3 VQPCSRCGYGVYPAEKI----SCIDQIWHKACFHCEVCKMMLSVNNFVSHQKKPYCHAH------ 57

  Fly   142 PKVVYEEFTPRKAELIIRENQPIKLPPDVAKASDKPSLGLDELQELNLRSKFKVFENGYEEHNNN 206
                    .|:........:.|:                     .||:|:        :.|..:.
Human    58 --------NPKNNTFTSVYHTPL---------------------NLNVRT--------FPEAISG 85

  Fly   207 LRERQDIAITHSKSIQSTLTKFHGLGIPNSELTKLDDKNSDNNS---------DGDGDMNFMC-- 260
            :.:::|  ....||:      ||.      ::...|.:.:.|..         .|.|:.|..|
Human    86 IHDQED--GEQCKSV------FHW------DMKSKDKEGAPNRQPLANERAYWTGYGEGNAWCPG 136

  Fly   261 --LKKEIER--ETPVGLGEAMNDIRSKFEQ----GDLMAKEGRREERKQEIQNIRSRLFLGKQAK 317
              ...||.|  |....|||   :....:||    |...|......:|.::...:.|::
Human   137 ALPDPEIVRMVEARKSLGE---EYTEDYEQPRGKGSFPAMITPAYQRAKKANQLASQV------- 191

  Fly   318 IKEMYKLAVAESEQPVTSVGKTPDICAIKPTQEIKNRFENGEVY--------------------K 362
               .||....|.....::|..||::...|...::::.....|.|                    |
Human   192 ---EYKRGHDERISRFSTVVDTPELLRSKAGAQLQSDVRYTEDYEQQRGKGSFPAMITPAYQIAK 253

  Fly   363 DSKILSSEV-------------------SCGI--HEDADVFESG-----------------ISKA 389
            .:..|:|:|                   :.||  .|.||.:..|                 |:.|
Human   254 RANELASDVRYHQQYQKEMRGMAGPAIGAEGILTRECADQYGQGYPEEYEEHRGKGSFPAMITPA 318

  Fly   390 SRN----------IFMKLDANIKSGLSNHVQYTLPDKKYQIHNQKVQEN---SDVEIVK--SDSK 439
            .:|          |..:.|.|...|.:::  ::||.:...:..|....|   |:||..|  ..|:
Human   319 YQNAKKAHELASDIKYRQDFNKMKGAAHY--HSLPAQDNLVLKQAQSVNKLVSEVEYKKDLESSR 381

  Fly   440 PEEVKVAT----EELSKKFKFFETYSPAENKKRIFRMTPPREGVVMFPPPDSETNQQISTTLFND 500
            ...:....    ..:||..||.......||.:.  .|....|||.|    |..|...:.......
Human   382 GHSINYCETPQFRNVSKISKFTSDNKYKENYQN--HMRGRYEGVGM----DRRTLHAMKVGSLAS 440

  Fly   501 NILQKT---------KTTSTILNKFR-EMEEQKMSDQQKKKNPKPLK--CFTPPPEISHQFIRSD 553
            |:..|.         ...:|:...:: .|:...:.|...:::...||  ..|..|:|....|.:.
Human   441 NVAYKADYKHDIVDYNYPATLTPSYQTAMKLVPLKDANYRQSIDKLKYSSVTDTPQIVQAKINAQ 505

  Fly   554 --TEEESDSDYEQNSENDEESEINPSNSYYNDKALLEAQSVARA-KQLRAKFEKWQNNEIEQEIK 615
              :.....:|||:|..|....:..|.        |::|::.|:. .:::.| |.|:  :.:.:..
Human   506 QLSHVNYRADYEKNKLNYTLPQDVPQ--------LVKAKTNAKLFSEVKYK-EGWE--KTKGKGF 559

  Fly   616 EGRIDVYSQLISNESIESAKAIRERFENMKKSETAM 651
            |.::|..|.|.:..|.|.|..|:.:.|..|....||
Human   560 EMKLDAMSLLAAKASGELASNIKYKEEYEKTKGKAM 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	15/55 (27%)
NRAP	NP_001248392.1	LIM_N_RAP	6..58	CDD:188830	16/69 (23%)
		Nebulin 1. /evidence=ECO:0000255	63..97		6/64 (9%)
		Nebulin 2. /evidence=ECO:0000255	156..166		2/9 (22%)
		Nebulin 3. /evidence=ECO:0000255	175..202		5/36 (14%)
		Nebulin 4. /evidence=ECO:0000255	203..237		6/33 (18%)
		NEBU	204..234	CDD:128523	6/29 (21%)
		Nebulin 5. /evidence=ECO:0000255	246..273		4/26 (15%)
		Nebulin 6. /evidence=ECO:0000255	298..307		0/8 (0%)
		Nebulin 7. /evidence=ECO:0000255	316..343		5/26 (19%)
		Nebulin	316..342	CDD:279252	5/25 (20%)
		Nebulin 8. /evidence=ECO:0000255	348..382		9/33 (27%)
		Nebulin 9. /evidence=ECO:0000255	389..417		6/29 (21%)
		Nebulin 10. /evidence=ECO:0000255	419..453		8/37 (22%)
		Nebulin 11. /evidence=ECO:0000255	487..521		9/33 (27%)
		NEBU	488..518	CDD:128523	6/29 (21%)
		Nebulin 12. /evidence=ECO:0000255	522..556		8/44 (18%)
		Nebulin	530..555	CDD:279252	7/35 (20%)
		Nebulin 13. /evidence=ECO:0000255	558..592		10/33 (30%)
		Nebulin	565..591	CDD:279252	8/25 (32%)
		Nebulin 14. /evidence=ECO:0000255	602..626
		Nebulin 15. /evidence=ECO:0000255	627..661
		NEBU	628..658	CDD:128523
		Nebulin 16. /evidence=ECO:0000255	662..692
		Nebulin 17. /evidence=ECO:0000255	702..724
		Nebulin 18. /evidence=ECO:0000255	726..760
		NEBU	727..757	CDD:128523
		Nebulin 19. /evidence=ECO:0000255	761..795
		NEBU	762..792	CDD:128523
		Nebulin 20. /evidence=ECO:0000255	797..831
		Nebulin 21. /evidence=ECO:0000255	844..869
		Nebulin 22. /evidence=ECO:0000255	870..896
		Nebulin 23. /evidence=ECO:0000255	901..935
		Nebulin 24. /evidence=ECO:0000255	945..963
		Nebulin 25. /evidence=ECO:0000255	969..1003
		NEBU	970..1000	CDD:128523
		Nebulin 26. /evidence=ECO:0000255	1004..1038
		NEBU	1005..1035	CDD:128523
		Nebulin 27. /evidence=ECO:0000255	1040..1074
		Nebulin	1049..1073	CDD:279252
		Nebulin 28. /evidence=ECO:0000255	1078..1112
		Nebulin 29. /evidence=ECO:0000255	1113..1139
		Nebulin 30. /evidence=ECO:0000255	1144..1178
		Nebulin 31. /evidence=ECO:0000255	1183..1206
		Nebulin 32. /evidence=ECO:0000255	1212..1246
		Nebulin 33. /evidence=ECO:0000255	1247..1281
		Nebulin 34. /evidence=ECO:0000255	1283..1317
		Nebulin 35. /evidence=ECO:0000255	1321..1355
		Nebulin 36. /evidence=ECO:0000255	1356..1390
		NEBU	1357..1387	CDD:128523
		Nebulin 37. /evidence=ECO:0000255	1391..1421
		Nebulin 38. /evidence=ECO:0000255	1429..1449
		Nebulin 39. /evidence=ECO:0000255	1455..1481
		Nebulin 40. /evidence=ECO:0000255	1490..1524
		Nebulin 41. /evidence=ECO:0000255	1526..1560
		Nebulin 42. /evidence=ECO:0000255	1564..1598
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1595..1620
		Nebulin 43. /evidence=ECO:0000255	1599..1626
		Nebulin 44. /evidence=ECO:0000255	1640..1664
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910