DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33521 and Mical

DIOPT Version :9

Sequence 1:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001247015.1	Gene:	Mical / 41225	FlyBaseID:	FBgn0053208	Length:	4743	Species:	Drosophila melanogaster

Alignment Length:	734	Identity:	137/734 - (18%)
Similarity:	258/734 - (35%)	Gaps:	217/734 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KKSKTNEYDNQNINMKKSFTKFDDLQKRNVIHVRSRDSKKAQSLFRSTIPEKVENCHQCKKPVYK 89
            ||.:.|. |.:|.....:.|     ...|.:..:| .||.|.:..:....||   |..||:.||.
  Fly  1052 KKDEANS-DEKNAGSSNATT-----NTNNTVIPKS-SSKVALAFKKQAASEK---CRFCKQTVYL 1106

  Fly    90 MEEVILSLKTATTIFHKTCLRCKDCGKHLKFDSY----NVHDGSLYCSMHFKLIFAPKVVYEEFT 150
            ||:..:.    ..:.|:.||:|..|..:|:...|    :...|..||:.||:|  .||.:.:...
  Fly  1107 MEKTTVE----GLVLHRNCLKCHHCHTNLRLGGYAFDRDDPQGRFYCTQHFRL--PPKPLPQRTN 1165

  Fly   151 PRKAELIIRENQPIKLP-----PDVAKASD-----KPSLGLDELQELNLRSKFKVFE----NGYE 201
            ..:.....:...|...|     |..|..|:     .|...:|.|:.....:......    |..:
  Fly  1166 KARKSAAAQPASPAVPPTAGSVPTAAATSEHMDTTPPRDQVDLLETSRANASADAMSDDEANVID 1230

  Fly   202 EH----NNNLRERQDIAITHSKSIQSTLTKFHGLGIPNSELTKLDDKNSDNNSDGDGDMNFMCLK 262
            ||    .|.|.|..:.:                    .|||:..|:  ||..||.:       :.
  Fly  1231 EHEWSGRNFLPESNNDS--------------------QSELSSSDE--SDTESDSE-------MF 1266

  Fly   263 KEIERETPVGL-----------------GEAMNDIRSKFEQGDLMAKEGRREERKQEIQNIRSRL 310
            :|.: ::|.|.                 .:..:|.....|.......||...::.:|::....||
  Fly  1267 EEAD-DSPFGAQTLQLASDWIGKQYCEDSDDSDDFYDSSEDDGKDDTEGEEFKKARELRRQEVRL 1330

  Fly   311 FLGKQAKIKEMYKLAVAESEQPVTSVGKTPDICAIKPTQEIKNRFENGEVYKDSKILSSEVSCGI 375
                                ||:.:     ::.....|:::|...:|.|...|...|.|
  Fly  1331 --------------------QPLPA-----NLPTDTETEKLKLNVDNKENMADRSSLKS------ 1364

  Fly   376 HEDADVFESG-------ISKASRNIFMKLDANIKSGLSNHVQYTLPDKKYQIHNQKVQENSDVEI 433
               .:.|||.       :|..:|....:|:.|.....|:.:: .:.:|.|.::|. |:.|.|:|:
  Fly  1365 ---GNSFESARSQPSTPLSTPTRVEMEQLERNAPRKFSSEIE-AISEKLYHMNNM-VKMNKDLEV 1424

  Fly   434 ------VKSDSKPEEVKVATEELSKKFKFF-ETYSPAENKKRIFRMTPPREGVVMFPPPDSETNQ 491
                  ||||        ...:|:.|.|:. |..:.|..:|    :||..........|.|:.::
  Fly  1425 LAKENLVKSD--------ILRKLTLKEKWLAENAAIAAGQK----VTPTPSATAPGLQPKSKFDE 1477

  Fly   492 QISTTLFNDNILQKTKTTSTILNKFREMEEQK--MSDQQKKKNPKPLKCFTPP------------ 542
            :....:.....:.:.|....|.....|::.:|  ..::.|::.|:|.....||
  Fly  1478 KFEKVVSPPQPVVEPKPKPVIDFNLDELKPRKPNFEERPKEQLPRPESLKKPPQQKPKGSSTNVS 1542

  Fly   543 -------------PEISHQFIRSDT--------------EEESDSDYEQNSENDEESEINPSNSY 580
                         |::....|.:::              :.::.||.:::.:.||:.|..|:
  Fly  1543 RSNSLKSNASNGSPKVKKAPISNNSKMQIEGILGTLRKIQSQNSSDQDEDMDVDEDVERKPN--- 1604

  Fly   581 YNDKALLEAQSVARAKQLRAKFEKWQNNEIEQEIKEGRIDVYSQLISNESIESAKA-----IRER 640
                           |:|.:|.:     ||:.....|.:|.....::..:: ||:|     :.:.
  Fly  1605 ---------------KELNSKLK-----EIQASSFAGTMDHIKSQLTMPTV-SAQAPPSMDLSKY 1648

  Fly   641 FENMKKSETAMENPSKTQI 659
            |.|.|:.:::..:.:|.|:
  Fly  1649 FPNQKQEKSSTSSTNKNQV 1667

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	17/59 (29%)
Mical	NP_001247015.1	MDR	<114..>160	CDD:302572
		CH	563..>629	CDD:294029
		LIM_Mical	1097..1153	CDD:188823	17/59 (29%)
		Ehrlichia_rpt	<2081..2479	CDD:118064
		DUF3585	4592..4705	CDD:288945
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910