DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33521 and rga1

DIOPT Version :9

Sequence 1:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_596743.1	Gene:	rga1 / 2541022	PomBaseID:	SPBC3F6.05	Length:	1150	Species:	Schizosaccharomyces pombe

Alignment Length:	819	Identity:	136/819 - (16%)
Similarity:	260/819 - (31%)	Gaps:	294/819 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLNPQSSKISFGNGLPLKKKKTKKSKTNEYDNQNINMKKSFTKFDDLQKRNVI------------ 55
            ||:.:.:.......||.:::..:....|:.:.|  ::|:|.|.......|.|.
pombe    61 SLSRRHTSAESRKALPNQQQLAQSGLLNKEEQQ--SLKRSDTSVFPKAVRKVSSSKICASCGQVI 123

  Fly    56 ---HVRSRDSKKAQSLFRSTIPEKVENCHQCKKPV----YKMEEVILSLKT---ATTIFHKTCLR 110
               :||:..:......||         ||.|...|    :.:::..|:.:.   .|..|.:..|.
pombe   124 SGQYVRALGNIYHLECFR---------CHDCNSLVASKFFPIDDPTLNKQVPLCETDYFRRLDLL 179

  Fly   111 CKDCGKHL----------KF-----------------DSYNVHDGSLYCSMHFKLIFAPKV---- 144
            |..||..|          ||                 |||..::|.:||..|:..:||.:.
pombe   180 CASCGMALRGYYITALNKKFHIEHFTCSLCYTVFGPNDSYYEYEGKVYCHYHYSTLFAARCCGCD 244

  Fly   145 ---------VYEEFTPRKAEL---IIRENQPIKLPPDVAKASDKPSLGLD-ELQELNLRSKFKVF 196
                     ||.....:...:   :|.:...:||   ..|.|.:.|...| ||.:..||.:.|..
pombe   245 GPILRQFVEVYRNGVSQNWHVPCHMIYKFWNVKL---CQKTSIETSKKKDSELSQSQLRKREKHL 306

  Fly   197 E----------NGYEEHNNNLRERQDIAITHSK-----------------------SIQSTLTKF 228
            |          :.:||:..:......:.:::.:                       |:::.|:.|
pombe   307 EQKIFHIWHALSYFEEYTASCISDMLLLVSNGEFTKSVICAQKFIRYIEILFKGIDSLETILSSF 371

  Fly   229 HGLGIPNSELTKLDDKN---------SDNNSDGDGDMNFMCLKKEIERETPVGLGEAMNDIRSKF 284
            |...:|.....||..|.         ..:|||              .|:..:     :.|..|.|
pombe   372 HAKSMPYVREAKLLCKKLVSIFALLAKCHNSD--------------IRDVAI-----VQDFLSLF 417

  Fly   285 E--------------QGDLMAKEGR--REERKQEIQNIRSRLFLGKQAKIKEMYKLAVAESEQPV 333
            .              .|.|..::..  :....|.:|.:....|:.::......:       :.|:
pombe   418 TGLAHYLKLLIRISLTGGLRLEQDHACKHALPQFLQTVEEARFVDQEGYDSSSF-------DMPL 475

  Fly   334 TSVGKTPDICAI--KPTQE-----------------IKNRFENGEVYKDSK--ILSSEVSCGI-- 375
            .....:.|:|.:  ...:|                 .|.::.|.|.|..::  ..:.::.|.:
pombe   476 NLANASSDLCYVCHSALEEDCVLLGEIRCHIGCLSCTKCKYNNRENYDWARWNNQTKQIECYLCY 540

  Fly   376 HEDADV--------FESGISKASRNIFMKLDANIKSGLSNHVQYTLPDKKYQIHNQKVQENSDVE 432
            .|.::|        ||. :|:.|:.|::...|.::       .||:           :.||:|
pombe   541 TESSNVSNDEPHPSFEY-VSRLSQYIYLLRIALVR-------LYTI-----------LMENND-- 584

  Fly   433 IVKSDSKPEEVKVATEELSKKFKFFETYSPAENKKRIFRMTPPREGVVMFPPPDSETNQQISTTL 497
              .|..||..|....|.:|...                                 ||.:|..||.
pombe   585 --SSQRKPLSVDPKQENVSSTV---------------------------------ETAKQAETTA 614

  Fly   498 FNDNILQKTKTTSTILNKFREMEEQKMSDQQKKKNPKPLKCFTPPPEISHQFIRSDTEEESDS-D 561
            .:|:..:...|    ||..|.::    |.:.:|..                  .::|:..|:| :
pombe   615 SSDSFRKYANT----LNDLRHLK----SSRNRKAT------------------SNETQSSSNSTE 653

  Fly   562 YEQNSENDEESEINPSNSYYNDKALLEAQSVAR--AKQLRAKFEKWQNNEI-----------EQE 613
            ..:.|:|..||..:.|..:::....:..:|:..  :..|..:.:.:..|..           ||.
pombe   654 TSKLSKNVSESGKDKSPHWHSHGGSITGKSIVEQASSPLERRMDAFDENRAFTLDDIPKVISEQR 718

  Fly   614 IKEGRIDVYSQLISNESIESAK---AIRERFENMKKSET 649
            .:|.|.:.:..:.|.......|   ||.::.:..:|..|
pombe   719 NREHRPNAFRHMPSYTDPSYRKNSGAIYDKNDGTQKGLT 757

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	20/89 (22%)
rga1	NP_596743.1	LIM1_Lrg1p_like	116..172	CDD:188777	10/64 (16%)
		LIM2_Lrg1p_like	180..232	CDD:188778	12/51 (24%)
		LIM	485..539	CDD:295319	7/53 (13%)
		RhoGAP_fLRG1	835..1044	CDD:239862
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24215
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100