DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33521 and mical3

DIOPT Version :9

Sequence 1:	NP_001014703.1	Gene:	CG33521 / 3346141	FlyBaseID:	FBgn0250819	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_031754432.1	Gene:	mical3 / 100486205	XenbaseID:	XB-GENE-996271	Length:	2242	Species:	Xenopus tropicalis

Alignment Length:	957	Identity:	156/957 - (16%)
Similarity:	287/957 - (29%)	Gaps:	404/957 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 DDLQKRNVIHVRSRDSKKAQSLFRSTIPEKV---ENCHQCKKPVYKMEEVILSLKTATTIFHKTC 108
            :.|||:..  .:....||..| ||...|:.:   :.|:.|::.||.||.    |......||::|
Frog   871 NQLQKKET--PKPLFGKKVGS-FRKEFPQNLGGSDVCYFCRRRVYVMER----LSAEGKFFHRSC 928

  Fly   109 LRCKDCGKHLKFD--SYNVHDGSLYCSMHF----------KLIFAPKVVYEEFTPRKAELIIREN 161
            .:|..|...|:..  :|::.||..||..|:          |....|.:..:|.|....:....|:
Frog   929 FKCDYCSTTLRLSCYAYDLEDGKFYCKPHYCYRRSGYSQRKRPAMPALSGKEVTRTVEDTPDAED 993

  Fly   162 Q---PIKLPPDVAKASDKPSL-GLDE----------------------LQELNLRSKFKVFENGY 200
            |   |: ||...|:.:..||: |:::                      ||:..|.   :|.|...
Frog   994 QGRAPL-LPAPAAEKTPGPSVNGVEDHSAAKRLRATPERIELENYRVSLQKEELE---EVPEETL 1054

  Fly   201 EEHN-NNLRERQDIAITHSKSIQSTLTKFHGL-----------------GIPNSELTKL------ 241
            .||| ::|.::.::....|.|.:|.:.:....                 |:|..|..|:
Frog  1055 AEHNLSSLLDKGEVEEVASSSSESEMEEEEDEEEEEEEPGECLPPSDLGGVPWKEAVKIHAKLKG 1119

  Fly   242 --------------------DDKNSDNNSDGDGDMN-----FMCLKKEIER---------ETPVG 272
                                :::..::..:.|.:::     :...::|:::         |..||
Frog  1120 QDIDVEVVGTQGAGGSEEEEEEEEEEDEEEEDEEVSSEEGEYCPWERELQQGLWIQRISDEDTVG 1184

  Fly   273 LGEAMN-----------------DIR-------------SKFEQGDL------------------ 289
            :.:|.|                 |:|             ||.|:|::
Frog  1185 IFKAGNLRLQQALSPVDPTEIKADVRWTHVREVKEERRGSKEERGEVSMSSPSKARHLHSHRHDP 1249

  Fly   290 -----------------------------------------------MAKEGRREERKQEIQNIR 307
                                                           :..:...|||.|:.|..:
Frog  1250 VRAWLESVSGATGEYEEGEEEELGTCLAQAEAAGDGDTSADLGDDDDIPSDAEAEERLQQSQRFK 1314

  Fly   308 SRLFLGKQAKIKEMYKLAVAESEQPVTSVGKTPDICAIKPTQEIKNRFENGEVYKDSKILSSEVS 372
            .:|.:.::.|:::....|:|:||...:.|...|....:.|.:.:|...|...|.....:.|.
Frog  1315 LKLDVAQEPKVEQPVLPAIADSESVPSPVSLAPKAPVLSPRRTLKAEAEKVPVMSPKAVTSP--- 1376

  Fly   373 CGIHEDADVFESGISKASRNIFMKLDANIKSGLSNHVQYTLPDKKYQIHNQKVQENSDV---EIV 434
             |....||.            ::.||::.|:    .|:...|.....:.:|.|.....|   ..|
Frog  1377 -GGRFFADP------------YLPLDSSNKA----LVEAKTPTPLSPVCSQPVPSQEPVIPTSPV 1424

  Fly   435 KSDSKPEEVKV---------------------ATE------------------------------ 448
            ||.|.|...:.                     ||:
Frog  1425 KSPSVPANTRPLISPSAPICSQPLPSSEGTLNATDRPPVRQQPSPLIPSTSLTKLPFTGHVMGSE 1489

  Fly   449 --------ELSKKFKFFETY--SPAENKKRIFRMTPPREGV--VMFP----------PPDSETNQ 491
                    |:.|:....|.:  ..||.::.:......|:.|  :.||          .|.|:..:
Frog  1490 QLVSPNAKEVLKRIDLIEEFWTKSAEIRRSLGLAPVDRDRVHEISFPALASTPLQPQAPKSKPEE 1554

  Fly   492 QISTTLFNDNILQKTKTTSTILNKFREM-------EEQKMSDQQKK------------------- 530
            |.|.:|....:.::...:...:.....:       :|.|.||.:||
Frog  1555 QKSPSLKPQQVARRVNPSRLDIELLSPLTPISPSEKELKSSDGEKKDISTSSGLGLNGSSITRTA 1619

  Fly   531 ---------------------------------------KN-----PKPLKCFTPPPE------- 544
                                                   :|     |.|....:.|||
Frog  1620 ASESFNTSDSAMLTPPSSPPPPPPQGEEPATLRRSRTPCQNGPESIPAPALAQSKPPEPKKSPRW 1684

  Fly   545 ---ISHQFIRSDTE----EESDSDYEQNSEND--EESEINPSNSYYNDKALLEAQSVARAKQLRA 600
               :...|:.|..|    ::.:..|::.:||.  :|....|..|              |.|..|.
Frog  1685 EESVRKSFVESVDEIPFADDVEDTYDERTENSSLQERFFTPPTS--------------RVKPHRI 1735

  Fly   601 KFEKWQNNEIEQEIKEGRIDVYSQLISNESIESAKAIRERFENMKKS 647
            .|.| :|.||....:  |:....:|:.:.:.|:.:...||.:..:||
Frog  1736 GFSK-ENGEIPSSSE--RVHHRKRLLPDVTQEAKERAEERMKAREKS 1779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33521	NP_001014703.1	LIM_Mical_like_2	80..136	CDD:188829	18/57 (32%)
mical3	XP_031754432.1	UbiH	87..>226	CDD:357568
		CH_MICAL3	514..624	CDD:409100
		LIM_Mical	904..958	CDD:188823	18/57 (32%)
		PHA03247	1222..>1479	CDD:223021	40/276 (14%)
		Herpes_BLLF1	<1358..1622	CDD:282904	42/283 (15%)
		DUF3585	2055..2220	CDD:403377
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910