DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pgk and pgk1

DIOPT Version :9

Sequence 1:	NP_001259956.1	Gene:	Pgk / 33461	FlyBaseID:	FBgn0250906	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_998552.1	Gene:	pgk1 / 406696	ZFINID:	ZDB-GENE-040426-2711	Length:	417	Species:	Danio rerio

Alignment Length:	412	Identity:	285/412 - (69%)
Similarity:	331/412 - (80%)	Gaps:	1/412 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NKLSIENLDLAGKRVLMRVDFNVPIKEGKITSNQRIVAALDSIKLALSKKAKSVVLMSHLGRPDG 68
            |||.::.:|:.||||:||||||||:|...||:||||.||:.||:..|...||:|.||||||||||
Zfish     5 NKLHLDKVDVKGKRVIMRVDFNVPMKNNVITNNQRIKAAVPSIQHCLDNCAKAVALMSHLGRPDG 69

  Fly    69 -NKNIKYTLAPVAAELKTLLGQDVIFLSDCVGSEVEAACKDPAPGSVILLENVRFYVEEEGKGLD 132
             ....||:|.|||||||.|||:||.||.||||.:||.||.||..||||||||:||:|.|||||.|
Zfish    70 VPMPDKYSLEPVAAELKNLLGKDVQFLKDCVGPDVEKACADPPAGSVILLENLRFHVAEEGKGKD 134

  Fly   133 ASGGKVKADPAKVKEFRASLAKLGDVYVNDAFGTAHRAHSSMMGDGFEQRAAGLLLNKELKYFSQ 197
            |||.|.||..|::..|||||:|||||||||||||||||||||:|....|:|||.|:.|||.||:.
Zfish   135 ASGNKTKASQAEIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAAGFLMKKELDYFAM 199

  Fly   198 ALDKPPNPFLAILGGAKVADKIQLIENLLDKVNEMIIGGGMAFTFLKVLNNMKIGGSLFDEEGSK 262
            ||:||..|||||||||||.||||||.|:|||||||||||||||||||||.||:||.||||||||.
Zfish   200 ALEKPQRPFLAILGGAKVKDKIQLINNMLDKVNEMIIGGGMAFTFLKVLKNMEIGTSLFDEEGST 264

  Fly   263 IVEKLVEKAKKNNVQLHLPVDFVCGDKFAENAAVSEATVEAGIPDGHMGLDVGPKTRELFAAPIA 327
            ||:.|:.||:||.|::.|||||:..|||.|.|....|||..|||.|.||||.||::.:|:|..:|
Zfish   265 IVKDLMAKAEKNGVKITLPVDFITADKFDEKATTGTATVAEGIPAGWMGLDCGPESSKLYAEAVA 329

  Fly   328 RAKLIVWNGPPGVFEFPNFANGTKSIMDGVVAATKNGTVSIIGGGDTASCCAKWNTEALVSHVST 392
            |||.||||||.||||:.|||:|||::||.||.|||||.::||||||||:|||||:||..||||||
Zfish   330 RAKQIVWNGPVGVFEWDNFAHGTKNMMDKVVEATKNGCITIIGGGDTATCCAKWDTEDKVSHVST 394

  Fly   393 GGGASLELLEGKTLPGVAALTS 414
            ||||||||||||.||||.||::
Zfish   395 GGGASLELLEGKVLPGVDALSN 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgk	NP_001259956.1	Phosphoglycerate_kinase	1..414	CDD:294132	285/410 (70%)
pgk1	NP_998552.1	PTZ00005	3..416	CDD:173310	285/410 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577693
Domainoid	1	1.000	540	1.000	Domainoid score	I258
eggNOG	1	0.900	-	-		E1_COG0126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21542
Inparanoid	1	1.050	558	1.000	Inparanoid score	I1068
OMA	1	1.010	-	-		QHG60610
OrthoDB	1	1.010	-	-		D367407at33208
OrthoFinder	1	1.000	-	-		FOG0001721
OrthoInspector	1	1.000	-	-		oto41234
orthoMCL	1	0.900	-	-		OOG6_100440
Panther	1	1.100	-	-	LDO	PTHR11406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R912
SonicParanoid	1	1.000	-	-		X1109
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800