DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgk and pgk1

DIOPT Version :9

Sequence 1:	NP_001259956.1	Gene:	Pgk / 33461	FlyBaseID:	FBgn0250906	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_596730.1	Gene:	pgk1 / 2539764	PomBaseID:	SPBC14F5.04c	Length:	414	Species:	Schizosaccharomyces pombe

Alignment Length:	410	Identity:	264/410 - (64%)
Similarity:	311/410 - (75%)	Gaps:	2/410 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLSIENLDLAGKRVLMRVDFNVPIKEGKITSNQRIVAALDSIKLALSKKAKSVVLMSHLGRPDGN 69
            ||:|.::||.||.||:|||||||:...:||:|.|||.||.:||.||.::.|:|:||||||||:|.
pombe     6 KLAITDVDLKGKNVLIRVDFNVPLDGDRITNNARIVGALPTIKYALEQQPKAVILMSHLGRPNGA 70

  Fly    70 KNIKYTLAPVAAELKTLLGQDVIFLSDCVGSEVEAACKDPAPGSVILLENVRFYVEEEGKGLDAS 134
            :..||:|.||||||..|||:.|.||.||||.|||.|||:...|.||||||:||::||||.. ...
pombe    71 RVAKYSLKPVAAELSKLLGKPVKFLDDCVGPEVEKACKEAKGGEVILLENLRFHIEEEGSA-KVD 134

  Fly   135 GGKVKADPAKVKEFRASLAKLGDVYVNDAFGTAHRAHSSMMGDGFEQRAAGLLLNKELKYFSQAL 199
            |.|||||.:.|:.||.||..|||::|||||||||||||||:|... .|.:|.|:.|||.|||:||
pombe   135 GKKVKADASAVEAFRKSLTSLGDIFVNDAFGTAHRAHSSMVGVDL-PRVSGFLMKKELDYFSKAL 198

  Fly   200 DKPPNPFLAILGGAKVADKIQLIENLLDKVNEMIIGGGMAFTFLKVLNNMKIGGSLFDEEGSKIV 264
            :.|..||||||||||||||||||:|||||||.:||.||||||||||||.||||.|||||.|||.|
pombe   199 ENPARPFLAILGGAKVADKIQLIDNLLDKVNRLIICGGMAFTFLKVLNGMKIGDSLFDEAGSKNV 263

  Fly   265 EKLVEKAKKNNVQLHLPVDFVCGDKFAENAAVSEATVEAGIPDGHMGLDVGPKTRELFAAPIARA 329
            |.::.|||||||::.||||||..|||.::|.|..||.|.|||||.||||.|||:...||..|..:
pombe   264 ESMMAKAKKNNVEVFLPVDFVTADKFDKDAKVGSATAEEGIPDGWMGLDCGPKSSAKFAEVITTS 328

  Fly   330 KLIVWNGPPGVFEFPNFANGTKSIMDGVVAATKNGTVSIIGGGDTASCCAKWNTEALVSHVSTGG 394
            |.||||||.|||||.|||.||||::|..|...:.|.|.|:||||||:...|:..|..:|||||||
pombe   329 KTIVWNGPAGVFEFDNFAKGTKSMLDACVKTCEAGNVVIVGGGDTATVAKKYGKEDALSHVSTGG 393

  Fly   395 GASLELLEGKTLPGVAALTS 414
            ||||||||||.||||.||:|
pombe   394 GASLELLEGKALPGVVALSS 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgk	NP_001259956.1	Phosphoglycerate_kinase	1..414	CDD:294132	263/408 (64%)
pgk1	NP_596730.1	PTZ00005	3..414	CDD:173310	264/410 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	482	1.000	Domainoid score	I62
eggNOG	1	0.900	-	-		E1_COG0126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21542
Inparanoid	1	1.050	504	1.000	Inparanoid score	I239
OMA	1	1.010	-	-		QHG60610
OrthoFinder	1	1.000	-	-		FOG0001721
OrthoInspector	1	1.000	-	-		oto101452
orthoMCL	1	0.900	-	-		OOG6_100440
Panther	1	1.100	-	-	LDO	PTHR11406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R912
SonicParanoid	1	1.000	-	-		X1109
TreeFam	1	0.960	-	-
	14	13.860