DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pgk and pgk-1

DIOPT Version :9

Sequence 1:	NP_001259956.1	Gene:	Pgk / 33461	FlyBaseID:	FBgn0250906	Length:	415	Species:	Drosophila melanogaster
Sequence 2:	NP_491245.1	Gene:	pgk-1 / 171965	WormBaseID:	WBGene00020185	Length:	417	Species:	Caenorhabditis elegans

Alignment Length:	414	Identity:	299/414 - (72%)
Similarity:	343/414 - (82%)	Gaps:	0/414 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 AFNKLSIENLDLAGKRVLMRVDFNVPIKEGKITSNQRIVAALDSIKLALSKKAKSVVLMSHLGRP 66
            :.|||:|:.|:|||||||:|||||||:|:||||:||||.||:.:|:.|||..|||||||||||||
Worm     3 SLNKLAIDQLNLAGKRVLIRVDFNVPLKDGKITNNQRIAAAVPTIQHALSNGAKSVVLMSHLGRP 67

  Fly    67 DGNKNIKYTLAPVAAELKTLLGQDVIFLSDCVGSEVEAACKDPAPGSVILLENVRFYVEEEGKGL 131
            ||.:..||||.|||.|||.||.:||:||.|||||||||||.||||||||||||:|:::||||||:
Worm    68 DGRRQDKYTLKPVAEELKALLKKDVLFLDDCVGSEVEAACADPAPGSVILLENLRYHLEEEGKGV 132

  Fly   132 DASGGKVKADPAKVKEFRASLAKLGDVYVNDAFGTAHRAHSSMMGDGFEQRAAGLLLNKELKYFS 196
            ||||.|||||.|.||:||.||.||||:||||||||||||||||:|....|||:|.||..||.|||
Worm   133 DASGAKVKADSAAVKKFRESLTKLGDIYVNDAFGTAHRAHSSMVGVEHSQRASGFLLKNELSYFS 197

  Fly   197 QALDKPPNPFLAILGGAKVADKIQLIENLLDKVNEMIIGGGMAFTFLKVLNNMKIGGSLFDEEGS 261
            :|||.|..||||||||||||||||||:||||||||||||||||:|||||...:|||.||:||||:
Worm   198 KALDNPARPFLAILGGAKVADKIQLIKNLLDKVNEMIIGGGMAYTFLKVAQGVKIGNSLYDEEGA 262

  Fly   262 KIVEKLVEKAKKNNVQLHLPVDFVCGDKFAENAAVSEATVEAGIPDGHMGLDVGPKTRELFAAPI 326
            |||.:|:|.||...||:|||||||..|||||:|.....|.|.|:|||||||||||::.::|||.|
Worm   263 KIVNELLEAAKAKGVQIHLPVDFVIADKFAEDATSKTVTAEEGVPDGHMGLDVGPESSKIFAAAI 327

  Fly   327 ARAKLIVWNGPPGVFEFPNFANGTKSIMDGVVAATKNGTVSIIGGGDTASCCAKWNTEALVSHVS 391
            .|||.||||||.|||||..||.||||:||.||.||..|.::||||||||:...|:|||..|||||
Worm   328 QRAKTIVWNGPAGVFEFDKFATGTKSLMDEVVKATAAGAITIIGGGDTATAAKKYNTEDKVSHVS 392

  Fly   392 TGGGASLELLEGKTLPGVAALTSA 415
            |||||||||||||.||||.||:.|
Worm   393 TGGGASLELLEGKVLPGVDALSPA 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pgk	NP_001259956.1	Phosphoglycerate_kinase	1..414	CDD:294132	298/411 (73%)
pgk-1	NP_491245.1	PTZ00005	5..414	CDD:173310	297/408 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158316
Domainoid	1	1.000	572	1.000	Domainoid score	I108
eggNOG	1	0.900	-	-		E1_COG0126
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21542
Inparanoid	1	1.050	591	1.000	Inparanoid score	I530
Isobase	1	0.950	-	0	Normalized mean entropy	S171
OMA	1	1.010	-	-		QHG60610
OrthoDB	1	1.010	-	-		D367407at33208
OrthoFinder	1	1.000	-	-		FOG0001721
OrthoInspector	1	1.000	-	-		oto19275
orthoMCL	1	0.900	-	-		OOG6_100440
Panther	1	1.100	-	-	LDO	PTHR11406
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R912
SonicParanoid	1	1.000	-	-		X1109
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790