DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cwc25 and Cwc25

DIOPT Version :9

Sequence 1:	NP_608705.1	Gene:	Cwc25 / 33460	FlyBaseID:	FBgn0031452	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001101765.1	Gene:	Cwc25 / 360613	RGDID:	1305258	Length:	415	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	164/528 - (31%)
Similarity:	262/528 - (49%)	Gaps:	120/528 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGGDLNLKKSWHPHTMKNQERVWKAEEQAKMEERKLQDLRKEINEERDREELRRLGESSGVLSN 65
            ||||||||||||||.|::|.|:|||||::.:.|.:|:::|::|:.|||.|||::|..|..|.:..
  Rat     1 MGGGDLNLKKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKK 65

  Fly    66 NGGAAGEAKLEWMYKNSTELINREEYLLGRKIDK-SFETLQAEESRQEQNTVGLKQTINHVEHDC 129
            .     |.||:|||:....:::|:||||||.||| .||.::..|:.....| ||
  Rat    66 K-----EEKLDWMYQGPGGMVSRDEYLLGRPIDKYVFEKMEEREAGCSSET-GL----------- 113

  Fly   130 VPFSIRTYRNVQSNEQVDIQRKTLEDPLMLIKQREMESRRKLLENPVKLKEIHRILKTEQEQKAA 194
            :|.||  :....:|..:|:..|..||||.:|:::|.|.:|::|.||||:::|..:|:...|
  Rat   114 LPGSI--FAPSGANSLLDMASKIREDPLFIIRKKEEEKKREVLNNPVKMRKIKELLQMSLE---- 172

  Fly   195 EGKKKNKKNKKSKKSKKKKKNRRSSNEESSDSESNDSDDDLDRKLARQ---VSKLKGDQGDLKLD 256
               ||.||.||.||.|.:|...|||:.:.|.||...|.....:|:|..   :||:.|
  Rat   173 ---KKEKKKKKEKKKKHRKHKHRSSSSDRSSSEDEQSHGRSQKKMANSFPVLSKVPG-------- 226

  Fly   257 KLLDAKYRTISNQLDMATKKKKSKKSKKKKSSDSSD--ESSDEEEEPRRKHKRSHSSEDRNQRER 319
                                    ...:.:.||.:.  :.|..|:...:.|.||
  Rat   227 ------------------------YGLQVRDSDRNQGLQGSLGEQRAVKNHSRS----------- 256

  Fly   320 RRSRSPRDRKKRQSRSPEQRQRQRSPEERRERRRSRSRSPLARRQRRTRSPEDRKARRQSKDTSK 384
                         |.||.:...::|.:|.|.|.| |||||    .|::.||     |...:.|||
  Rat   257 -------------SSSPARHASRKSTKEERSRDR-RSRSP----GRKSLSP-----RPSKQHTSK 298

  Fly   385 -QREKRRSRTPEERSRSKRSRSRSSKGDDKRRIAERPPPSRPTGKPKLSEADREARLREMMDNAT 448
             .|::|.|.:|::....:|..|..::                    |||..:.|.:.:|||:||.
  Rat   299 ANRKERDSPSPKKEVYQRRHASGYTR--------------------KLSAEELERKRQEMMENAK 343

  Fly   449 WREADRSQVVRKHREAYAREEAQNRERDFDKEFINKEVKKAIANHNSIGDRIRANLNNIQRTASS 513
            |||.:|...:::|.:...:|....|......:||:: :|...|:.:|:.||::.|::::|||:.:
  Rat   344 WREEERLNTLKRHAKEDEQEHRLERLDSRSGKFIHR-MKLESASTSSLEDRVKRNIHSLQRTSMA 407

  Fly   514 MDSNFARK 521
            ::.||.|:
  Rat   408 LEKNFMRR 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cwc25	NP_608705.1	Cir_N	11..44	CDD:287204	15/32 (47%)
Cwc25	NP_608705.1	CWC25	72..174	CDD:289319	37/102 (36%)
Cwc25	NP_001101765.1	Cir_N	11..>37	CDD:287204	13/25 (52%)
Cwc25	NP_001101765.1	CWC25	67..156	CDD:289319	29/89 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340655
Domainoid	1	1.000	108	1.000	Domainoid score	I6357
eggNOG	1	0.900	-	-		E1_KOG3869
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3560
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1635950at2759
OrthoFinder	1	1.000	-	-		FOG0003473
OrthoInspector	1	1.000	-	-		oto96586
orthoMCL	1	0.900	-	-		OOG6_103842
Panther	1	1.100	-	-	LDO	PTHR16196
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3363
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760