Protein Alignment CG9961 and PGK1

DIOPT Version :10

• Sequence 1: NP_608704.2
• Gene: CG9961 / 33459
• FlyBaseID: FBgn0031451
• Length: 448
• Species: Drosophila melanogaster
• Sequence 2: NP_000282.1
• Gene: PGK1 / 5230
• HGNCID: 8896
• Length: 417
• Species: Homo sapiens
• Alignment Length: 412
• Identity: 251/412 - (60%)
• Similarity: 310/412 - (75%)
• Gaps: 2/412 - (0%)

  Fly    37 KLSLKNVDVAGKRVFMRVDFNVPMKDGKITNNQRIVSALPSIKYALDKKCKSLVLASHLGRPDG- 100
            ||:|..:||.||||.||||||||||:.:|||||||.:|:||||:.||...||:||.||||||||
Human     6 KLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGV 70

  Fly   101 KKNKKFSLEPVAKELESVLGQPVQFLDDCVGDSTLRALKDPSDGTVFLLENLRFYAEETGSSKDD 165
            ....|:||||||.||:|:||:.|.||.||||....:|..:|:.|:|.|||||||:.||.|..||.
Human    71 PMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDA 135

  Fly   166 NKKKVKADPAKVKEFRAKLAQLGEIYVNDAFGTAHRPHSSMMGDGYKVRAAGFLLDKELEYFAKV 230
            :..||||:|||::.|||.|::||::|||||||||||.||||:|.....:|.|||:.|||.||||.
Human   136 SGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKA 200

  Fly   231 LHDPAKPFLAILGGAKIADKIPLITNLLNNVTAMIISGGMAFTFLKVLNGMEIGKSLFDEKGSEL 295
            |..|.:||||||||||:||||.||.|:|:.|..|||.||||||||||||.||||.|||||:|:::
Human   201 LESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKI 265

  Fly   296 VNDIVCKAKEKDVNILFPIDFVIANKIDKEPDKVEHVDATQGIPEDMMGLDHGQASSQMFAGAIC 360
            |.|::.||::..|.|..|:|||.|:|.| |..|........|||...||||.|..||:.:|.|:.
Human   266 VKDLMSKAEKNGVKITLPVDFVTADKFD-ENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVT 329

  Fly   361 ASKTIVWNGPPGLFENELFSKGTESMLEAVIGATNRGATTIVGGGDTATACLKFGGADKVSHVST 425
            .:|.||||||.|:||.|.|::||:::::.|:.||:||..||:|||||||.|.|:...||||||||
Human   330 RAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVST 394

  Fly   426 GGGASLELLEGKVLPGVAALSD 447
            |||||||||||||||||.|||:
Human   395 GGGASLELLEGKVLPGVDALSN 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9961	NP_608704.2	Phosphoglycerate_kinase	36..447	CDD:444741	250/410 (61%)
PGK1	NP_000282.1	PTZ00005	3..417	CDD:173310	251/412 (61%)
		Mitochondrial targeting region exposed following cis-trans isomerization by PIN1 and recognized by the TOM complex for mitochondrial translocation of the protein. /evidence=ECO:0000269|PubMed:26942675	38..43		3/4 (75%)