DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrs and GGA1

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_010645.1	Gene:	GGA1 / 851960	SGDID:	S000002766	Length:	557	Species:	Saccharomyces cerevisiae

Alignment Length:	497	Identity:	105/497 - (21%)
Similarity:	190/497 - (38%)	Gaps:	100/497 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKD-VTPKNAFAAIKKKMNSPNPHSSCYSLLVLE 67
            ||..:.::.|......|||....|.:.|.||.|. .||:.|..||:|.:|:.:..::.::|.:|:
Yeast    20 SSLLRKIQRACRSTLPEPDLGLNLDVADYINSKQGATPREAVLAIEKLVNNGDTQAAVFALSLLD 84

  Fly    68 SIVKNCGAPVHEEVFTKENC-EMFSSFLESTP--HENVRQKMLELVQTW--------AYAFRSSD 121
            .:|||||..:|.::..||.. ::...|.|..|  :..|:|.:||.::.|        :|    .|
Yeast    85 VLVKNCGYSIHLQISRKEFLNDLVKRFPEQPPLRYSKVQQMILEAIEEWYQTICKHASY----KD 145

  Fly   122 KYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQV 186
            ..|.|.|...:||.||:|||::...:   .|...||       .:.|........:...:
Yeast   146 DLQYINDMHKLLKYKGYTFPKVGSEN---LAVLRPN-------DQLRTPSELQEEQERAQ----- 195

  Fly   187 FCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPA-----DSELPAEYLNST 246
                 .||...|.:.|...:::..:.....:       .|.|...:.|     ::||......:.
Yeast   196 -----AAKLEELLRSGKPDDLKEANKLMKIM-------AGFKDDTKVAVKQAINNELNKLKRKAD 248

  Fly   247 LAQQVQTPARKTEQELKEEEELQLALALSQSE----AEQQK------PKLQSLPPAAYRMQQRSP 301
            |..::.|.|.:.:.|.:..:||...|..:|.:    .|:::      ..|........::.:|..
Yeast   249 LFNEMLTSADEPDLENEAIQELYGDLKSAQPKFKKLIEEERDDDALVSNLSKFNDLVIQLLKRYK 313

  Fly   302 SPEAPPEPKEYHQQPEEATNP---ELAKYLNRSYWEQRKISESSSMASPS-APSPM--------- 353
            |.:...|        ||...|   |.||.||...::....:.:.|:.||| :..|.
Yeast   314 SIKGMKE--------EELNVPDTNEPAKELNLIDFDDDTTANTPSVTSPSKSLQPFDDLLGDFNK 370

  Fly   354 -----PPTPQPQQIM-----PLQVKSA--DEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISND 406
                 |.:||....:     ....||:  |.:..|......:|.:..:.|.:...:....|.||.
Yeast   371 VSLSSPKSPQENDTVVDILGDAHSKSSGIDLLDFDSQPGESKTALSAYSNSIVLPNGLLNSSSNS 435

  Fly   407 SSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIK 448
            ..:..         ..|...:.:.|..|:.||..::.:|:::
Yeast   436 KEITA---------QSQRHILNQSDHLRIDYELTRESMTKLR 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	48/150 (32%)
		FYVE_Hrs	157..217	CDD:277260	6/59 (10%)
		Hrs_helical	377..471	CDD:289018	11/72 (15%)
		GBP_C	<456..520	CDD:303769
		coiled coil	501..512	CDD:293879
GGA1	NP_010645.1	VHS_GGA_fungi	22..160	CDD:340795	41/141 (29%)
		GGA_N-GAT	195..222	CDD:408115	4/43 (9%)
		GAT_GGA_fungi	233..320	CDD:410583	14/86 (16%)
		Alpha_adaptinC2	443..555	CDD:397151	6/26 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341411
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840