DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrs and AT5G16880

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001331679.1	Gene:	AT5G16880 / 831551	AraportID:	AT5G16880	Length:	407	Species:	Arabidopsis thaliana

Alignment Length:	330	Identity:	83/330 - (25%)
Similarity:	124/330 - (37%)	Gaps:	53/330 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 DKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIVK 71
            ||.:|:||:....||||...|.|||.|||:.:........|||::....|.....:|::||:.||
plant    49 DKIVEDATTENLEEPDWDMNLEICDMINQETINSVELIRGIKKRIMMKQPRIQYLALVLLETCVK 113

  Fly    72 NCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAK 136
            ||.....|....:...||.....:.....|.|.|.|.|::.|..:..........::|...|||:
plant   114 NCEKAFSEVAAERVLDEMVKLIDDPQTVVNNRNKALMLIEAWGESTSELRYLPVFEETYKSLKAR 178

  Fly   137 GHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKH---HCRNCGQV--FCGQCTAKQC 196
            |..||. |:.:::     ||.:...|......:........|   |.:....|  |..:.|.:..
plant   179 GIRFPG-RDNESL-----APIFTPARSTPAPELNADLPQHVHEPAHIQYDVPVRSFTAEQTKEAF 237

  Fly   197 PLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQV---QTPARKT 258
            .:.:..||           .|....|.|        |....|..: |.:||.||.   ||..::.
plant   238 DIARNSIE-----------LLSTVLSSS--------PQHDALQDD-LTTTLVQQCRQSQTTVQRI 282

  Fly   259 EQELKEEEEL---------QLALALSQSEAEQQKPK--LQSLPPAAYRMQQRSPSPEAPPEPKEY 312
            .:...|.|.|         :|...||:.| |..||.  |.|..||...:.:.       |:....
plant   283 IETAGENEALLFEALNVNDELVKTLSKYE-EMNKPSAPLTSHEPAMIPVAEE-------PDDSPI 339

  Fly   313 HQQPE 317
            |.:.|
plant   340 HGREE 344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	43/135 (32%)
		FYVE_Hrs	157..217	CDD:277260	8/64 (13%)
		Hrs_helical	377..471	CDD:289018
		GBP_C	<456..520	CDD:303769
		coiled coil	501..512	CDD:293879
AT5G16880	NP_001331679.1	VHS	49..177	CDD:340765	38/127 (30%)
AT5G16880	NP_001331679.1	GAT_GGA-like_plant	237..313	CDD:410579	21/96 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910