DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrs and gga1

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001004000.2	Gene:	gga1 / 798361	ZFINID:	ZDB-GENE-040822-13	Length:	635	Species:	Danio rerio

Alignment Length:	709	Identity:	151/709 - (21%)
Similarity:	246/709 - (34%)	Gaps:	203/709 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESI 69
            |.:..:..||:.|..|.||.||.|.||:::.:...|:.|...:..|:.||....:..:|:|||:.
Zfish     9 SLESRINKATNPLNRETDWESIQLFCDQLSNEPEGPQLATRLLAHKIQSPQEWEAIQALMVLETC 73

  Fly    70 VKNCGAPVHEEV----FTKENCEMFS-SFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDT 129
            |||||...|.||    |..|..::.| .:|.|...|.|::|:||::.:|..:.....|   |.|.
Zfish    74 VKNCGKRFHNEVGKFRFLNELIKVVSPKYLGSRAPEPVKKKVLEMMYSWTVSLPEETK---ISDA 135

  Fly   130 MTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAK 194
            ..:||.:|           :...|  |:..|.:.|                            ..
Zfish   136 YQMLKKQG-----------IIKQD--PDLPDDKPC----------------------------PP 159

  Fly   195 QCPLPKYGI-EKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEY--LNSTLAQQVQTPAR 256
            ..|.||..| |.|.:                  :|...|..:|..|.:.  .|..:.:.||...:
Zfish   160 PPPRPKNAIFEDEEK------------------SKMLSRLLNSSHPEDLRAANKLIKEMVQEDQK 206

  Fly   257 KTE---------QELKEEEELQLAL-------ALSQSEAEQQK---PKLQSLPPAAYRM-QQRSP 301
            :.|         ||:||...|...|       :.|||..|..|   .:.:.:.|..:|: .....
Zfish   207 RMEKVSKRVNAIQEVKESVGLLTQLLGDYSKDSSSQSNEELIKDLYQRCEKMRPTLFRLASDTED 271

  Fly   302 SPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSP-------------M 353
            :.||..|..:        .|..|.:.:| .|.:..:..|.:..||.||..|             .
Zfish   272 NDEALAEILQ--------ANDSLTQVIN-LYRQLVRGEEVNGEASSSATHPGSSNALLDLTGLDT 327

  Fly   354 PPTPQ-----PQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRG-----RSISNDSS 408
            .|:.|     |.|...|.:...|    ||..:...|:|...:...:|..:.|     .|.:.|:.
Zfish   328 SPSAQSFSEFPSQTQELGISLLD----DELMSLGLTEVNSNLTSSQSGDAMGWNTFQSSETEDTP 388

  Fly   409 VQ---TLFMTLTSLHSQ----QLSYIKEMDD-----KRMWYEQLQDKLTQIKDSRAALDQLRQEH 461
            |.   .:.:.:||....    .::..|.:|:     |.:..:.|..:..|:|     .|:|:.:.
Zfish   389 VMPEPAVLLPVTSATKTPVPVPVTSTKSLDELDLLGKTLLQQSLPPEGLQVK-----WDKLQSQS 448

  Fly   462 VEKLRRIAEEQERQRQMQMAQKLDIMRKK---KQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQ 523
            ...||.:..:.........:..|....:.   ....|..|..::|.::
Zfish   449 KPTLRDLQIKSGNNAATSPSPVLSFSSEPGSLLNSQLTPQDDVSLVKV----------------- 496

  Fly   524 YLMGQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQ---------GPAPAPNGHGQ 579
                 :.|.....|.|.:|......|.|..::: :|...|...|.         ..||.|..:.:
Zfish   497 -----TVPLESIKPSSMLPVTIFDKHSLRVLFH-FAKDPPPARPDVLVVIISMLSSAPLPITNVR 555

  Fly   580 FQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGN--PQMMPPMPENQFANNPAAILQL 636
            |||        |:.:.|...|||        |.|:  |...|.:|       ||||.|:
Zfish   556 FQA--------AVPKNMRVKLQP--------PSGSDLPAFNPVLP-------PAAITQV 591

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	46/142 (32%)
		FYVE_Hrs	157..217	CDD:277260	8/60 (13%)
		Hrs_helical	377..471	CDD:289018	20/110 (18%)
		GBP_C	<456..520	CDD:303769	7/66 (11%)
		coiled coil	501..512	CDD:293879	1/10 (10%)
gga1	NP_001004000.2	VHS_GGA	9..147	CDD:239624	46/151 (30%)
		GAT_GGA1_GGA2	210..298	CDD:260097	20/96 (21%)
		Alpha_adaptinC2	513..627	CDD:197886	26/103 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910