Protein Alignment Hrs and Zfyve19

DIOPT Version :9

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: XP_006500266.1
• Gene: Zfyve19 / 72008
• MGIID: 1919258
• Length: 396
• Species: Mus musculus
• Alignment Length: 472
• Identity: 93/472 - (19%)
• Similarity: 155/472 - (32%)
• Gaps: 166/472 - (35%)

  Fly   164 CHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAK 228
            |:.|.|:||...:::.|:|||:.||..|.:....:|:.| ..:.:||..|...|.|.:|.:....
Mouse     5 CYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAG-NTQQKVCKQCHTILTRGSSDNASKW 68

  Fly   229 SGP---RPADSELPAEYLNST-----LAQQVQTPAR---KTEQELK-----EEEELQLALALSQS 277
            |.|   :...:.|.|:..:||     |..:.|..|.   :..||.|     .:.|::..||..:.
Mouse    69 SPPQNYKKRVAALEAKKKSSTSHSQSLTHKDQAIAERLARLRQENKPKSVPSQAEIEARLAALKD 133

  Fly   278 EAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESS 342
            |.:...|..|.:......:|.|.| |.....|.  ||.|:..|
Mouse   134 EVQGPIPSTQEMEDRLAALQGRVP-PSHTVRPA--HQAPDTRT---------------------- 173

  Fly   343 SMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDE------FAANMRTQVEIFVNRMKSNSSRGR 401
                           |.||...|..:...||.|||      .||:::..:.....|.:..:|:|:
Mouse   174 ---------------QAQQTQDLLTQLTAEVAIDENCQPRASAASLQNDLNKGAARSQRTNSQGQ 223

  Fly   402 SISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLR 466
            :                  ||.|...|        |:.|.:...::::     :..|||.:..|
Mouse   224 A------------------SQSLEEEK--------YKLLAEAAVELQE-----ENTRQERILAL- 256

  Fly   467 RIAEEQERQRQMQMAQKLDIMRKKKQEY----LQYQRQLALQRIQEQEREMQLRQEQQKAQYLMG 527
                    .:::.:.:..|..|...|:|    .....:.|:||:.:|..|.....|
Mouse   257 --------AKRLAVLKGQDPSRVTLQDYHLPDSDEDEETAIQRVMQQLTEEAALDE--------- 304

  Fly   528 QSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAI 592
                                           |:|.  .:|:.|||....
Mouse   305 -------------------------------ASGF--NIPEKPAPGSRA---------------- 320

  Fly   593 QQPMPPNLQPGGLMQQP 609
             ||....::|..|:|.|
Mouse   321 -QPCKAEMEPQSLLQGP 336

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626
		FYVE_Hrs	157..217	CDD:277260	17/52 (33%)
		Hrs_helical	377..471	CDD:289018	16/99 (16%)
		GBP_C	<456..520	CDD:303769	14/67 (21%)
		coiled coil	501..512	CDD:293879	4/10 (40%)
Zfyve19	XP_006500266.1	FYVE_ZFY19	4..54	CDD:277288	16/49 (33%)
		PRK11281	122..>305	CDD:236892	49/302 (16%)
		Bbox1_ANCHR-like	343..387	CDD:380875

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1818
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900