back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrs and Stam2

DIOPT Version :10

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_062641.1	Gene:	Stam2 / 56324	MGIID:	1929100	Length:	523	Species:	Mus musculus

Alignment Length:	711	Identity:	139/711 - (19%)
Similarity:	230/711 - (32%)	Gaps:	252/711 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESIV 70
            |::::|.||:......||..|:.|||.:.......|:...||.|::|...||.:..:|.:|.:.|
Mouse     9 FEQDVEKATNEYNTTEDWSLIMDICDRVGSTPSGAKDCLKAIMKRVNHKVPHVALQALTLLGACV 73

  Fly    71 KNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKA 135
            .|||...|.||.:::......|.:::..|..|.:|:..|:..|:..|:...::..|..|:..:|.
Mouse    74 ANCGKIFHLEVCSRDFATEVRSVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKE 138

  Fly   136 KGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPK 200
            :|.|||.                                             .|..|.
Mouse   139 EGVTFPS---------------------------------------------AGSQTV------- 151

  Fly   201 YGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKEE 265
                                   :..||:|                      |...|.    ||:
Mouse   152 -----------------------AAAAKNG----------------------TSLNKN----KED 167

  Fly   266 EELQLALALSQSEAEQQKPKLQSL-PPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLN 329
            |::..|:.||..|.:||..:.::| |||                        |...|.:.|:.:
Mouse   168 EDIAKAIELSLQEQKQQYTETKALYPPA------------------------ESQLNNKAARRV- 207

  Fly   330 RSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQI-DEFAANMRTQVEIFVNRM 393
            |:.::...:.::.                      |..|..:.:.: |:..||.          .
Mouse   208 RALYDFEAVEDNE----------------------LTFKHGELITVLDDSDANW----------W 240

  Fly   394 KSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLR 458
            :..:.||..:...:.|.|...|             |::...:      |||..|.|.   :::::
Mouse   241 QGENHRGTGLFPSNFVTTDLST-------------EVETATV------DKLNVIDDD---VEEIK 283

  Fly   459 QEHVEKLRRIAEEQERQRQMQMAQKLDIMRKK--KQEYLQYQ---RQLA------LQRIQEQERE 512
            :...|.:  ..:|.:..|.:|:.|.:|....|  .|:.|..:   :|:.      |:.|..:..|
Mouse   284 KSEPEPV--YIDEGKMDRALQILQSIDPKESKPDSQDLLDLEDVCQQMGPMIDEKLEEIDRKHSE 346

  Fly   513 M-QLRQEQQKAQYLMGQ---SAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVP---------- 563
            : :|..:..:|..|..:   .||.:      :|.....|:|     |.|.|||||
Mouse   347 LSELNVKVLEALDLYNKLVNEAPVY------SVYSKLHPAH-----YPPAAAGVPVQTYPVQSHG 400

  Fly   564 -GYLPQGPAP---------APNGHGQFQAIPPGMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMM 618
             .||..|...         .|:..|..:::||.|.:.......||.|..|   |...  .||..|
Mouse   401 GNYLGHGIHQVSVAQNYNLGPDPMGSLRSLPPNMNSVTAHTVQPPYLSTG---QDTV--SNPSYM 460

  Fly   619 PPMPENQFANNPAAILQ-----------------LPQQHSIAQPPQIPFQPQPQQIPGQQP 662
            ......|.|...||..|                 |||..........|...|||....|||
Mouse   461 NQSSRLQAAAGTAAYTQPVGMSTDVSSFQNTASGLPQLAGFPVAVPAPVAAQPQASYHQQP 521

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.