DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hrs and Hgs

DIOPT Version :9

Sequence 1:NP_525099.3 Gene:Hrs / 33458 FlyBaseID:FBgn0031450 Length:760 Species:Drosophila melanogaster
Sequence 2:XP_038942636.1 Gene:Hgs / 56084 RGDID:69225 Length:860 Species:Rattus norvegicus


Alignment Length:866 Identity:350/866 - (40%)
Similarity:456/866 - (52%) Gaps:184/866 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESI 69
            :|::.|:.|||.|.||.||.|||.|||.|.|.|...|.|..:||||:|..|||.:.|:|.|:||:
  Rat    69 TFERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMESV 133

  Fly    70 VKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILK 134
            |||||..||:||..|:..|.....|:.....|||.|:|.|:|.||:|||:..||:.::||..|:|
  Rat   134 VKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMK 198

  Fly   135 AKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLP 199
            .:||.|||.:|:||||.|:.||:|.|...||||||:|....||||||.|||:|||:|::|...:|
  Rat   199 VEGHVFP
EFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIP 263

  Fly   200 KYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKE 264
            |:|||||||||:.|:..|.:...|...       :.:|||.|||.|.|:||.|.|.::.|..|:|
  Rat   264 KFGIEKEVRVCEPCYEQLNKKAEGKAA-------STTELPPEYLTSPLSQQSQLPPKRDETALQE 321

  Fly   265 EEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRS---------PSP---EAPPEPKEYHQQPE 317
            ||||||||||||||||:::           ||:|:|         |:|   .|||....|.....
  Rat   322 EEELQLALALSQSEAEEKE-----------RMRQKSTYTAHPKSEPAPLASSAPPAGSLYSSPVN 375

  Fly   318 ------EATNPELAKYLNRSYWEQRKISESSSMASPSAPSPM-PPTPQ-------PQQIMPLQVK 368
                  |..:||||:||||:||| :|..|:....:||||.|: .|..|       |..::...:.
  Rat   376 SSAPLAEDIDPELARYLNRNYWE-KKQEEARKSPTPSAPVPLTEPAAQPGEGHTAPNSMVEAPLP 439

  Fly   369 SADEVQI--------------------DEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLF 413
            ..|...|                    ::|...::..|..||||||||..|||||:|||:|.:||
  Rat   440 ETDSQPITSCSGPFSEQYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLF 504

  Fly   414 MTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQM 478
            .::.|.|.|.|..:..:|::|::||.|||||.||:|:|.||..||:||.|||||.|||.|||||:
  Rat   505 QSINSTHPQLLELLNRLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQI 569

  Fly   479 QMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAP--PFPYMPPSAV 541
            |:||||:|||:||||||:.|||||:||:||||:|.|:|.||||....|....|  |.||....|:
  Rat   570 QLAQKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAM 634

  Fly   542 PQHGSPSHQ------LNNVYNPYAAGVPG------YLPQGPAPAPNGHGQFQAIPPGMYNPAI-- 592
            |..|...:|      ....::| |..|.|      |:.| ||||.   |.:.::|....:|::  
  Rat   635 PTAGGVLYQPSGPTSFPGTFSP-AGSVEGSPMHGVYMSQ-PAPAT---GPYPSMPGTTADPSMVS 694

  Fly   593 ---------------QQPMPPNLQPGGLMQQPAP-PG-------NPQMMPPMPENQFANNPAAIL 634
                           |....|...|.....||.| ||       .||.:|            ||.
  Rat   695 AYMYPAGAPGAQAAPQAQAGPTTNPAYSSYQPTPTPGYQNVASQAPQSLP------------AIS 747

  Fly   635 QLPQQHSI----AQPPQIPFQP---QP-------QQI-----PGQQPQQ----IPGQQPQQIPGQ 676
            |.||..:|    :||..:.:||   ||       .||     |...||.    :|||. ..:|.|
  Rat   748 QPPQTSNIGYMGSQPMSMGYQPYNMQPGGSVSVWSQITQCWAPSYFPQNLMTTLPGQD-ASLPAQ 811

  Fly   677 QPQQIPGQQP--QQIPVQQPQPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQN 739
            || .|.||||  ||:......||           |.||.||.||.                    
  Rat   812 QP-YITGQQPMYQQMAPSTGPPQ-----------QQPPVAQPPPT-------------------- 844

  Fly   740 EPGPAPVKAEEPATAELISFD 760
             .|| |.:..|   .:|||||
  Rat   845 -QGP-PAQGNE---TQLISFD 860

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HrsNP_525099.3 VHS_Hrs_Vps27p 2..143 CDD:239626 68/137 (50%)
FYVE_Hrs 157..217 CDD:277260 35/59 (59%)
Hrs_helical 377..471 CDD:289018 50/93 (54%)
GBP_C <456..520 CDD:303769 46/63 (73%)
coiled coil 501..512 CDD:293879 8/10 (80%)
HgsXP_038942636.1 VHS_Hrs 68..205 CDD:340771 66/135 (49%)
FYVE_Hrs 221..281 CDD:277260 35/59 (59%)
PLN03209 <283..441 CDD:178748 64/176 (36%)
GAT_Hrs 467..562 CDD:410592 50/94 (53%)
G_path_suppress 560..809 CDD:406402 93/266 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166340990
Domainoid 1 1.000 133 1.000 Domainoid score I4951
eggNOG 1 0.900 - - E1_KOG1818
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37954
Inparanoid 1 1.050 540 1.000 Inparanoid score I1141
OMA 1 1.010 - - QHG45851
OrthoDB 1 1.010 - - D334336at33208
OrthoFinder 1 1.000 - - FOG0005737
OrthoInspector 1 1.000 - - oto97207
orthoMCL 1 0.900 - - OOG6_106317
Panther 1 1.100 - - LDO PTHR46275
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X4133
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.810

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