DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrs and tom1l2

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_009304960.1	Gene:	tom1l2 / 560327	ZFINID:	ZDB-GENE-061013-3	Length:	527	Species:	Danio rerio

Alignment Length:	546	Identity:	120/546 - (21%)
Similarity:	184/546 - (33%)	Gaps:	148/546 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMN-SPNPHSSCYSLLVLESIVKNC 73
            :|.||.......||...:.|||.||:.:..||:|..|:||::| :.|......:|.|||:.||||
Zfish    17 IERATDGSLQSEDWTLNMEICDIINETEDGPKDAMRAVKKRLNGNKNYREVMLTLTVLETCVKNC 81

  Fly    74 GAPVHEEVFTKENCEMFSSFLES------TPHEN----VRQKMLELVQTWAYAFRSSDKYQAIKD 128
            |...|..|.|::       |::.      :|..|    |:.|:|.|:|.||.|||||.....:..
Zfish    82 GYRFHMLVTTRD-------FIDGVLVKIISPKNNPPAIVQDKVLALIQAWADAFRSSPDLTGVVH 139

  Fly   129 TMTILKAKGHTFP--ELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQC 191
            ....:|.||..||  ||.....:.|...                                   |.
Zfish   140 VYEEMKRKGIEFPRSELETLSPIHTPQR-----------------------------------QQ 169

  Fly   192 TAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADS---ELPAEYLNSTLAQ-QVQ 252
            ||.:....||.            |.:|        .|..|.||.:   ..|..:.:..:.. .:.
Zfish   170 TAPEMDQQKYS------------APVQ--------PKPQPHPASAPPFTAPVAHTSPQMPNLHIA 214

  Fly   253 TPARKT-EQELKEEEELQLALA--------LSQSEAEQQKPK----LQSLPPAAYRMQQR----- 299
            .|...: ||..|...||.:...        |::....|:.|.    ||.|......||||
Zfish   215 GPINPSPEQICKLRSELDIVRGNTKVMSEMLTEMVPGQEDPSDHELLQELNRTCRAMQQRIVELI 279

  Fly   300 -SPSPEAPPEP---------------KEYHQ----QPEEATNPELAKYLNRSYWEQRKISESSSM 344
             ..|.|...|.               :.|.:    :..:..|..|.:.||.:       :|.:.:
Zfish   280 SRVSNEEVTEELLHVNDDLNNIFLRYERYERFRSGRTAQGVNNGLREVLNEA-------TEDNLI 337

  Fly   345 ----ASPSAPSP----MPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGR 401
                .||:..||    .||:..|..:.|  |:||..|.:....|.:....:.....:.|.::...
Zfish   338 DLGPGSPAVVSPRISATPPSSLPPSVAP--VRSASPVTLSSRLAGLDVGSDSVSGTLSSLATCQP 400

  Fly   402 SISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLR-------- 458
            ....|...||...|:....|......|.........:..|...|...|..:.:|.:.
Zfish   401 QDDFDMFAQTRTGTVPEWKSAPFEDTKASSGVAPTLDVRQQNATAALDQSSVMDDIEEWLSTDVK 465

  Fly   459 ----QEHV--EKLRRIAEEQERQRQM 478
                :|.|  |:..:..||:.:..:|
Zfish   466 GDEGEEGVTSEEFDKFLEERAKAAEM 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	50/145 (34%)
		FYVE_Hrs	157..217	CDD:277260	6/59 (10%)
		Hrs_helical	377..471	CDD:289018	15/107 (14%)
		GBP_C	<456..520	CDD:303769	6/37 (16%)
		coiled coil	501..512	CDD:293879
tom1l2	XP_009304960.1	VHS_Tom1	12..152	CDD:239623	48/141 (34%)
tom1l2	XP_009304960.1	GAT_TM1L2	221..312	CDD:260096	19/90 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910