DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrs and hgs

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_012822051.1	Gene:	hgs / 549267	XenbaseID:	XB-GENE-1016033	Length:	783	Species:	Xenopus tropicalis

Alignment Length:	794	Identity:	339/794 - (42%)
Similarity:	439/794 - (55%)	Gaps:	126/794 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLESI 69
            :|::.|:.|||.|.||.||.|||.|||.|.|.|...|.|.|:||||:|..|||.:.::|.||||:
Frog     7 TFERLLDKATSQLLLETDWESILQICDMIRQGDTQAKYAVASIKKKINDKNPHVALFALEVLESV 71

  Fly    70 VKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILK 134
            |||||..||:||..|:..|......:.....|||.|:|.|:|.||:|||:..||:.::||..|:|
Frog    72 VKNCGQHVHDEVANKQTMEELKELQKRQVEPNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIMK 136

  Fly   135 AKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLP 199
            .:||.|||.:|:||||.|:.||:|.|...||||||:|....||||||.|||:|||:|::|...:|
Frog   137 VEGHNFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTIP 201

  Fly   200 KYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQT------PARKT 258
            |:|||||||||:.|:..|.:  .|.|.:.||     .|||.|||.|.|:||.|.      |.:|.
Frog   202 KFGIEKEVRVCEPCYEQLNK--KGEGKSASG-----VELPPEYLTSPLSQQSQVEDIPSMPPKKD 259

  Fly   259 EQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQR---SPSPEAPPEPKEYHQQP---- 316
            |..|:||||||||:||||||||:::           ||:|:   |..|:|.|.|......|
Frog   260 ESALQEEEELQLAIALSQSEAEEKE-----------RMRQKTTYSMYPKADPTPITSSAPPVTTL 313

  Fly   317 -----------EEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPM--PPTPQ----PQQIMP 364
                       .|..:||||:||||:||| :|..|.....:||||.|:  |...|    |..:|.
Frog   314 YSAALNSSAPLAEEIDPELARYLNRNYWE-KKQEEVRKSPTPSAPVPISEPAVLQGGDVPVTVME 377

  Fly   365 LQVKSAD-EVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIK 428
            .|.::.: |...::|...::..|..|:||||||..|||||:|||:|.:||.::.::|.|.|..:.
Frog   378 QQYQNGESEENHEQFLKALQNAVTTFLNRMKSNQMRGRSITNDSAVLSLFQSINNMHPQLLEMLN 442

  Fly   429 EMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQE 493
            ::|::|::||.|||||.||:|:|.||:.||.||.|||||.|||.|||||:|:||||:|||:||||
Frog   443 QLDERRLYYEGLQDKLAQIRDARGALNALRDEHREKLRRAAEEAERQRQIQLAQKLEIMRQKKQE 507

  Fly   494 YLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAPPF--PY-------------MPPSAVPQ 543
            ||:.|||||:||:||||:|.|||.||||....|....|.|  ||             .|||..|.
Frog   508 YLEMQRQLAIQRLQEQEKERQLRLEQQKQTIQMRAQMPAFSLPYAQLQSLPATGGIMYPPSGPPA 572

  Fly   544 H-----------GSPSHQLNNVY-NPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPAIQ-QP 595
            :           |||.|   .|| ||  :|.|.   ..|.||....|:......|.:...:. :|
Frog   573 YPGTFSPSGSVEGSPMH---GVYMNP--SGQPA---TAPYPAMQVQGEMSRCLTGCWKSCLYVRP 629

  Fly   596 -------MPPNL----------QPGGLMQQPAPPGNP--QMMPPMPENQFANNPAAILQLP---Q 638
                   ..||:          .|.....|..|..||  ....|.|...:.|  .|...||   |
Frog   630 NQNRVFLTDPNMVNAYMYTAGCAPTAQQGQAVPTTNPTYTSYQPTPTQAYQN--VASQSLPSISQ 692

  Fly   639 QHSI-------AQPPQIPFQPQPQQ-----IPGQQP--QQIPGQQPQQIPGQQP--QQIPGQQPQ 687
            ..|.       ||...:|:||...|     :|||.|  ..:|.||...|.||||  ||:|....|
Frog   693 TASAGAVGYMGAQSVPMPYQPYNMQNLMSTLPGQDPSLSNLPSQQQPFIGGQQPMYQQMPVVGGQ 757

  Fly   688 QIPVQQPQPQPQMG 701
            |.|.|||....|.|
Frog   758 QQPAQQPAAHGQQG 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	68/137 (50%)
		FYVE_Hrs	157..217	CDD:277260	35/59 (59%)
		Hrs_helical	377..471	CDD:289018	48/93 (52%)
		GBP_C	<456..520	CDD:303769	47/63 (75%)
		coiled coil	501..512	CDD:293879	8/10 (80%)
hgs	XP_012822051.1	VHS_Hrs_Vps27p	4..145	CDD:239626	68/137 (50%)
		FYVE_Hrs	159..219	CDD:277260	35/59 (59%)
		Hrs_helical	391..485	CDD:289018	48/93 (52%)
		MAP7	<476..>546	CDD:283355	47/69 (68%)
		GBP_C	<477..557	CDD:303769	51/79 (65%)
		coiled coil	526..537	CDD:293879	8/10 (80%)
		coiled coil	546..557	CDD:293879	3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I5268
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37954
Inparanoid	1	1.050	510	1.000	Inparanoid score	I1285
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D334336at33208
OrthoFinder	1	1.000	-	-		FOG0005737
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46275
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4133
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160