DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrs and Zfyve19

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	XP_038961609.1	Gene:	Zfyve19 / 499871	RGDID:	1561576	Length:	393	Species:	Rattus norvegicus

Alignment Length:	405	Identity:	86/405 - (21%)
Similarity:	144/405 - (35%)	Gaps:	108/405 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 CHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAK 228
            |:.|.|:||...:::.|:|||:.||..|.:....:|:.| ..:.:||..|...|.|.:|.:....
  Rat     5 CYGCAVKFTLFKKEYGCKNCGRAFCNGCLSFSALVPRAG-NTQQKVCKQCHTVLTRGSSDTASKW 68

  Fly   229 SGPRPADSELPA-EYLNSTLAQQVQTPARKTE----------QELK-----EEEELQLALALSQS 277
            |.|:.....:.| |....:.|.|.|....|.:          ||.|     .:.|::..||..:.
  Rat    69 SPPQNYKKRVAALEAKKKSSASQSQGLTHKDQAIAERLARLRQENKPKSIPSQAEIEARLAALKD 133

  Fly   278 EAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESS 342
            |.:...|..|.:......:|.|:|.|..   .:..||.|:..|
  Rat   134 EVQGPIPSTQEMEDRLAALQGRAPPPHT---MRPVHQAPDTRT---------------------- 173

  Fly   343 SMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDS 407
                           |.||...|..:...||.|||   |.:.:|.....:...|....|:...||
  Rat   174 ---------------QAQQTQDLLTQLTAEVAIDE---NWQPRVSAAPPQNSLNKGGTRNQHTDS 220

  Fly   408 SVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQ 472
            ..|      .||                  |:.::||            |.:..||    :.||.
  Rat   221 QGQ------ASL------------------EEEKNKL------------LAEASVE----LQEEN 245

  Fly   473 ERQ-RQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQE-QQKAQYLMGQSAPPFPY 535
            .|| |.:.:|::|.:::.:....:..|........::::.|..:|:. ||..:......|..|
  Rat   246 TRQERILALARRLAVLKGQDPSRVTLQDYHLPDSDEDEDEETAIRRVLQQLTEEAALDEASGF-- 308

  Fly   536 MPPSAVPQHGSPSHQ 550
                .:|:..:|:.|
  Rat   309 ----NIPEEPAPASQ 319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626
		FYVE_Hrs	157..217	CDD:277260	17/52 (33%)
		Hrs_helical	377..471	CDD:289018	16/93 (17%)
		GBP_C	<456..520	CDD:303769	13/65 (20%)
		coiled coil	501..512	CDD:293879	0/10 (0%)
Zfyve19	XP_038961609.1	FYVE_ZFY19	4..54	CDD:277288	16/49 (33%)
Zfyve19	XP_038961609.1	Bbox1_ANCHR-like	340..384	CDD:380875
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1818
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900