Protein Alignment Hrs and Tom1

DIOPT Version :10

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_001008366.1
• Gene: Tom1 / 361370
• RGDID: 1308024
• Length: 492
• Species: Rattus norvegicus
• Alignment Length: 507
• Identity: 113/507 - (22%)
• Similarity: 170/507 - (33%)
• Gaps: 165/507 - (32%)

  Fly     2 FRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKK-MNSPNPHSSCYSLLV 65
            |.|...:.:|.||.......||...:.|||.||:.:..||:||.|:||: :.:.|.|....:|.|
  Rat     9 FSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDAFRAVKKRIVGNKNFHEVMLALTV 73

  Fly    66 LESIVKNCGAPVHEEVFTK---ENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIK 127
            ||:.|||||...|..|.::   ||..:.:...::.|...|..|:|.|:|:||.|||||.....:.
  Rat    74 LETCVKNCGHRFHVLVASQDFVENVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVV 138

  Fly   128 DTMTILKAKGHTFPELREAD----------AMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRN 182
            .....|:.||..|| :.:.|          .:|.::| |:          |.....:|..|.
  Rat   139 AVYEDLRRKGLEFP-MTDLDMLSPIHTPQRTVFNSET-PS----------RQNPVVSNSSHR--- 188

  Fly   183 CGQVFCGQCTAKQCPLPKYGI-----------------EKEVRVCDG------------------ 212
                  |..:....|||...:                 ..|:.:.:|
  Rat   189 ------GDLSQHATPLPTPAVLPGDSPITPTPEQIGKLRSELEMVNGNVRVMSEMLTELVPTQVE 247

  Fly   213 -------------CFAALQR-----------------------------------------PTSG 223
                         |.|..||                                         ....
  Rat   248 PADLELLQELNRTCRAMQQRILELIPRISNEQLTEELLMINDNLNNVFLRHERFERFRTGQTAKA 312

  Fly   224 SGGAK-------SGPRPA-----DSELPAEYLNSTLAQQVQTPARKTEQELKEEEELQL-ALALS 275
            ||.|:       .||.||     .|:|....|.|:   :|:...:..|.....|::..: ||...
  Rat   313 SGEAELAADLIDMGPDPAATSNLSSQLAGVDLGSS---RVRAGLQSLEASGHLEDDFDMFALTRG 374

  Fly   276 QSEAEQQKPKLQSLPPA----AYRMQQRSPSPEAPPEPK----------------EYHQQPEEAT 320
            .|.|:|:|......|..    |..:..|..|..|.|..:                ...::|...|
  Rat   375 SSLADQRKGVKYEAPQTTDGLAGALDARQQSTGAIPATQARIMEDIEQWLSTDVGSSAEEPSGVT 439

  Fly   321 NPELAKYLNRSYWEQRKISES-SSMASPSAPSPMPPTPQPQQIMPLQVKSAD 371
            :.|..|:|.    |:.|.::. .::|||||..|..|.|........|.|..|
  Rat   440 SEEFDKFLE----ERAKAADRLPNLASPSAEGPPRPCPGAAPRRKTQEKDDD 487

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs	4..141	CDD:340771	49/140 (35%)
		FYVE_Hrs	157..217	CDD:277260	11/107 (10%)
		GAT_Hrs	376..471	CDD:410592
		PABP-1234	<501..641	CDD:130689
Tom1	NP_001008366.1	VHS_Tom1	12..148	CDD:340792	46/135 (34%)
		GAT_TOM1	214..308	CDD:260094	6/93 (6%)