Protein Alignment Hrs and Stam

DIOPT Version :9

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Alignment Length: 828
• Identity: 184/828 - (22%)
• Similarity: 290/828 - (35%)
• Gaps: 254/828 - (30%)

  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLES 68
            |.||.::|.|||......:|..||.:||::.......|:...|:.::|...:||....::.:|::
  Fly     8 SPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQAITLLDA 72

  Fly    69 IVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWA-YAFRSSDKYQAIKDTMTI 132
            :..|||.|:|.||.:::....|...| :.....|..||.::::.|| ..:::..:...|......
  Fly    73 LSNNCGKPLHLEVASRDFETEFRRLL-AKAQPKVSLKMRQVLKNWAENDYKNDRELDLIPALYAK 136

  Fly   133 LKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCP 197
            |:.:|:.|..|.:..:...|:                                        |...
  Fly   137 LRQEGYDFKNLGDKTSKTVAE----------------------------------------KAAA 161

  Fly   198 LPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQEL 262
            |||                             .|....|:
  Fly   162 LPK-----------------------------DPNVVSSQ------------------------- 172

  Fly   263 KEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKY 327
            :||:::..|:.||..| .:..||..|:          :.:..|...|..|         |..|
  Fly   173 QEEDDIAKAIELSLKE-NKGSPKTGSV----------ASTGTASAYPSLY---------PSFA-- 215

  Fly   328 LNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPL-QVKSADEVQIDEFAANMRTQVEIFV- 390
                         .:..::|||.:...|.|:|:::..| ..::|:|.::..||..:     |.|
  Fly   216 -------------GTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEI-----IHVL 262

  Fly   391 -----NRMKSNSSRGRSI--SN----DSSVQTLFMTLTSLH-SQQLSYIKEMDDKRMWYEQLQDK 443
                 |..|..:.||..:  ||    |.||....:.:...| |...:..:|:|..    ..||.|
  Fly   263 DDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSA----AALQQK 323

  Fly   444 LTQIKDSRAALD--QLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQL--ALQ 504
             |:...:.||..  ::.:..:::|..:..|...:   ..:|..|.|.:.:||..|....:  .|:
  Fly   324 -TEAAAAAAAAQPVEIDESKIDRLLHLLHEANPE---DPSQDSDEMLQLEQEVHQMGPLIDAELE 384

  Fly   505 RIQEQEREMQ----------------LRQEQQKAQYLMGQS-----------------APPFP-- 534
            |:..:..::.                :|.::..|.:....:                 ||.:|
  Fly   385 RVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPAA 449

  Fly   535 --YMPPSAVPQHGSPSHQLNNVYNP------YAAGVP-GYL--PQGPAPAP--NGH-GQFQAIPP 585
              :.|....|  |..|.....|.||      .|.|.| |||  |||..|.|  ||| .|..::|.
  Fly   450 GGFPPAQNYP--GMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQNGHAAQMNSLPA 512

  Fly   586 GMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIP- 649
            .:..|....|||   ||  :..||.|....|...|:|::.         |.|.|....||||.|
  Fly   513 HLTQPTGTAPMP---QP--IYTQPTPVTTQQQQQPLPQHP---------QQPPQQQGQQPPQHPQ 563

  Fly   650 ----FQPQPQ--QIPG-----QQPQQIPGQQPQQIPGQQPQQIP---GQQPQQI---PVQQP--- 694
                ..||.|  |:|.     |||||.|.  |......|.||.|   |.||...   |...|
  Fly   564 NSYHIDPQSQYAQVPPAVTQIQQPQQPPA--PHAYMSPQHQQAPPPQGYQPGPNLYGPNGSPAVV 626

  Fly   695 QPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPG 742
            .||..|.....||...||..|...:    :.|:.|::.|..||...||
  Fly   627 NPQSYMSPQQQQQQHPPPHDQFSQL----HQQMAAMSMAGGPPVGAPG 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	36/139 (26%)
		FYVE_Hrs	157..217	CDD:277260	4/59 (7%)
		Hrs_helical	377..471	CDD:289018	24/108 (22%)
		GBP_C	<456..520	CDD:303769	11/81 (14%)
		coiled coil	501..512	CDD:293879	2/12 (17%)
Stam	NP_477448.1	VHS_STAM	10..154	CDD:239625	36/144 (25%)
		SH3_STAM	235..288	CDD:212754	13/57 (23%)
		GAT	340..412	CDD:281166	10/74 (14%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438664
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840