Protein Alignment Hrs and Stam

DIOPT Version :10

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_477448.1
• Gene: Stam / 34505
• FlyBaseID: FBgn0027363
• Length: 689
• Species: Drosophila melanogaster
• Alignment Length: 828
• Identity: 184/828 - (22%)
• Similarity: 290/828 - (35%)
• Gaps: 254/828 - (30%)

  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLES 68
            |.||.::|.|||......:|..||.:||::.......|:...|:.::|...:||....::.:|::
  Fly     8 SPFDADVEKATSETNTNDNWSLILDVCDKVTTNPRLAKDCLKAVMRRMGHTDPHVVMQAITLLDA 72

  Fly    69 IVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWA-YAFRSSDKYQAIKDTMTI 132
            :..|||.|:|.||.:::....|...| :.....|..||.::::.|| ..:::..:...|......
  Fly    73 LSNNCGKPLHLEVASRDFETEFRRLL-AKAQPKVSLKMRQVLKNWAENDYKNDRELDLIPALYAK 136

  Fly   133 LKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCP 197
            |:.:|:.|..|.:..:...|:                                        |...
  Fly   137 LRQEGYDFKNLGDKTSKTVAE----------------------------------------KAAA 161

  Fly   198 LPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQEL 262
            |||                             .|....|:
  Fly   162 LPK-----------------------------DPNVVSSQ------------------------- 172

  Fly   263 KEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEATNPELAKY 327
            :||:::..|:.||..| .:..||..|:          :.:..|...|..|         |..|
  Fly   173 QEEDDIAKAIELSLKE-NKGSPKTGSV----------ASTGTASAYPSLY---------PSFA-- 215

  Fly   328 LNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPL-QVKSADEVQIDEFAANMRTQVEIFV- 390
                         .:..::|||.:...|.|:|:::..| ..::|:|.::..||..:     |.|
  Fly   216 -------------GTGSSAPSAEASSAPAPEPRKVRALYDFEAAEENELTFFAGEI-----IHVL 262

  Fly   391 -----NRMKSNSSRGRSI--SN----DSSVQTLFMTLTSLH-SQQLSYIKEMDDKRMWYEQLQDK 443
                 |..|..:.||..:  ||    |.||....:.:...| |...:..:|:|..    ..||.|
  Fly   263 DDSDPNWWKGYNQRGEGLFPSNFVTADLSVDPERLDINQQHKSAAAAGQRELDSA----AALQQK 323

  Fly   444 LTQIKDSRAALD--QLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQL--ALQ 504
             |:...:.||..  ::.:..:::|..:..|...:   ..:|..|.|.:.:||..|....:  .|:
  Fly   324 -TEAAAAAAAAQPVEIDESKIDRLLHLLHEANPE---DPSQDSDEMLQLEQEVHQMGPLIDAELE 384

  Fly   505 RIQEQEREMQ----------------LRQEQQKAQYLMGQS-----------------APPFP-- 534
            |:..:..::.                :|.::..|.:....:                 ||.:|
  Fly   385 RVDRKHAQLTQLSSDLVDAINLYHTLMRDDRAAAGHFAAAAGGFMPGLAGFPGAALYGAPGYPAA 449

  Fly   535 --YMPPSAVPQHGSPSHQLNNVYNP------YAAGVP-GYL--PQGPAPAP--NGH-GQFQAIPP 585
              :.|....|  |..|.....|.||      .|.|.| |||  |||..|.|  ||| .|..::|.
  Fly   450 GGFPPAQNYP--GMHSMPYGPVPNPPTSAPSQAPGAPGGYLGQPQGQVPLPYQNGHAAQMNSLPA 512

  Fly   586 GMYNPAIQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPPQIP- 649
            .:..|....|||   ||  :..||.|....|...|:|::.         |.|.|....||||.|
  Fly   513 HLTQPTGTAPMP---QP--IYTQPTPVTTQQQQQPLPQHP---------QQPPQQQGQQPPQHPQ 563

  Fly   650 ----FQPQPQ--QIPG-----QQPQQIPGQQPQQIPGQQPQQIP---GQQPQQI---PVQQP--- 694
                ..||.|  |:|.     |||||.|.  |......|.||.|   |.||...   |...|
  Fly   564 NSYHIDPQSQYAQVPPAVTQIQQPQQPPA--PHAYMSPQHQQAPPPQGYQPGPNLYGPNGSPAVV 626

  Fly   695 QPQPQMGHVMLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPG 742
            .||..|.....||...||..|...:    :.|:.|::.|..||...||
  Fly   627 NPQSYMSPQQQQQQHPPPHDQFSQL----HQQMAAMSMAGGPPVGAPG 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs	4..141	CDD:340771	35/137 (26%)
		FYVE_Hrs	157..217	CDD:277260	4/59 (7%)
		GAT_Hrs	376..471	CDD:410592	24/109 (22%)
		PABP-1234	<501..641	CDD:130689	45/190 (24%)
Stam	NP_477448.1	VHS_STAM	10..141	CDD:340770	33/131 (25%)
		SH3_STAM	235..288	CDD:212754	13/57 (23%)
		GAT_STAM	337..413	CDD:410593	10/78 (13%)
		PHA03247	<436..526	CDD:223021	30/94 (32%)