DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hrs and CG41099

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_001015359.1	Gene:	CG41099 / 3355072	FlyBaseID:	FBgn0039955	Length:	1124	Species:	Drosophila melanogaster

Alignment Length:	176	Identity:	56/176 - (31%)
Similarity:	72/176 - (40%)	Gaps:	41/176 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PVHEEVFTKEN------CEMFSSFLESTPHENVR-----------------QKMLELVQTWAYAF 117
            |:||.....|:      ||:   ||||.|...:.                 |..|..:...|.|.
  Fly   961 PLHELCRVVEDSTAGLICEL---FLESMPKYPINIPDMDGNTPLLLSFMRGQSPLCKILVKAGAC 1022

  Fly   118 RSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPN---WADGRVCHRCRVEFTFTNRKHH 179
            ..::.    ||.:.|...|..|...|..     ..|..|.   ||:...|..|...||.|.||||
  Fly  1023 LGTEN----KDGINIFNFKLATDQLLHN-----LLDQLPQESPWAESDYCQHCTNRFTITMRKHH 1078

  Fly   180 CRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSG 225
            ||:||:|.|.:|:....|:.|:||.|.||||..||..||   .|:|
  Fly  1079 CRHCGRVLCSKCSCNDVPILKFGINKPVRVCTVCFNVLQ---CGNG 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	20/89 (22%)
		FYVE_Hrs	157..217	CDD:277260	29/62 (47%)
		Hrs_helical	377..471	CDD:289018
		GBP_C	<456..520	CDD:303769
		coiled coil	501..512	CDD:293879
CG41099	NP_001015359.1	BTB	67..164	CDD:279045
		BTB	75..166	CDD:197585
		ANK	252..385	CDD:238125
		ANK repeat	291..322	CDD:293786
		ANK repeat	325..362	CDD:293786
		Ank_2	330..431	CDD:289560
		ANK	463..595	CDD:238125
		ANK repeat	468..501	CDD:293786
		Ank_2	473..572	CDD:289560
		ANK repeat	503..539	CDD:293786
		ANK	536..660	CDD:238125
		ANK repeat	541..572	CDD:293786
		ANK repeat	574..637	CDD:293786
		Ank_2	579..670	CDD:289560
		ANK repeat	639..670	CDD:293786
		Ank_2	644..752	CDD:289560
		ANK repeat	672..721	CDD:293786
		ANK	721..843	CDD:238125
		ANK repeat	723..752	CDD:293786
		ANKYR	752..977	CDD:223738	4/15 (27%)
		ANK repeat	754..786	CDD:293786
		ANK	820..944	CDD:238125
		ANK repeat	822..855	CDD:293786
		ANK repeat	857..888	CDD:293786
		ANK	885..1017	CDD:238125	13/58 (22%)
		ANK repeat	890..921	CDD:293786
		ANK repeat	923..955	CDD:293786
		ANK repeat	996..1021	CDD:293786	3/24 (13%)
		FYVE_ANFY1	1054..1116	CDD:277267	29/61 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	73	1.000	Domainoid score	I3266
eggNOG	1	0.900	-	-		E1_KOG1818
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.900