DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrs and Gga

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_572571.1	Gene:	Gga / 31902	FlyBaseID:	FBgn0030141	Length:	660	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	136/701 - (19%)
Similarity:	232/701 - (33%)	Gaps:	192/701 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLES 68
            |..::.||.||:..: :.|...:.:.|..:.........|...|..|:.|.|...:..::.:||.
  Fly     6 SIMEEMLERATNPAQ-KIDELGVQMFCIVVKSNAQLVHKAQEMIVAKVRSTNVTEATRAISLLEE 69

  Fly    69 IVKNCGAPVHEEV----FTKENCEMFSSFLE--STPHENVRQKMLELVQTWAYAFRSSDKYQAIK 127
            .:..||....:|.    |..|...:.|...:  .|||| |:|:::|.:..|...|   .:.|.|:
  Fly    70 CMTQCGDDFQDEASKFRFLNELIRLVSKKYKGAETPHE-VKQRIMECLLLWTTEF---PQRQKIR 130

  Fly   128 DTMTILKAKG---HTFPEL----REA------DAMFT----ADTAPNWADGRVC----------- 164
            |...:|:.:|   |...|.    ||:      :|||.    ::...|:....:.
  Fly   131 DAYDMLRKEGDIEHGTTEAAVAKRESVLGTIDEAMFAKLIKSNNPENFKRANLLLQYRMAQEARR 195

  Fly   165 ------HR---CRVEFTF-----------------TNRKHH----CRNCGQVFCGQCTAKQCPLP 199
                  ||   |.|:.|.                 :...|.    |:....:|        ..||
  Fly   196 NDLLAQHRLVLCEVQETMQLLNQMLDTYDPANQDVSETLHELYKSCKKHKPIF--------QHLP 252

  Fly   200 KYGIEKEVR-VCD----GC--FAALQR-------PTSGSGGA--KSGPRPADSELPAEYLNSTLA 248
            :...:.:.: |.|    .|  .|.:||       ||..:..|  .|.|..|.|      :.||.:
  Fly   253 QLLDDSDAQLVADTLDANCALLATMQRYKLLVPSPTRSTAAALTTSAPTVASS------VKSTAS 311

  Fly   249 QQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYR-------MQQRSPSPEAP 306
            ....|.:....|.|.|    .|...|.....:.......|||.||..       :.....|..|.
  Fly   312 STTATTSSNNAQLLNE----LLGDLLIDGSNKAATTATTSLPNAAASGSNPLADLSDIFSSALAE 372

  Fly   307 PEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPT----PQP-------- 359
            .|.|:..|..:.||.     .|......|...:|:.:..:..:.|.:|.|    ||.
  Fly   373 SEAKQQSQPFQNATT-----LLEPQVISQGTTTEALANGNGGSASKVPETIRKMPQIDMLSEELF 432

  Fly   360 QQIMPLQVKSADEVQIDEFAANMRTQVEIFVN-----RMKSNSSRGRSISND------SSVQTLF 413
            |||:|.|         |...:..|...:|.:|     ||...:....:.:||      .::.|..
  Fly   433 QQILPTQ---------DRMPSFKRDPEKITLNDLARERMHIKAPEEPTTANDPASDSAPAIATAT 488

  Fly   414 MTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSR------AALDQLRQEHVEKLRRIAEEQ 472
            .|:.|:....|.    .||.....|.:...:|.:..::      ..||.::....:::  :.::.
  Fly   489 ATVDSIDDVPLL----SDDVEKKDEAVVAPVTVVPPAKPLSEINVELDNIQATGEQRI--VLDDD 547

  Fly   473 ERQRQMQMAQK----------LDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMG 527
            :.|..:.....          :....|.:|....:|.:.::::             ..|.:.|
  Fly   548 DMQLSLNFTSDRPGHRVSVIVISAQNKSRQPVRDFQFEASVKK-------------PCKVRLL-- 597

  Fly   528 QSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVP-----GY-LPQGPAP 572
              .|....|||....:..:|.:|:..:.||....|.     || |...|.|
  Fly   598 --TPTDSQMPPHKPFRPATPINQVMLLLNPTGKAVDVTCIVGYKLGDDPDP 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	35/147 (24%)
		FYVE_Hrs	157..217	CDD:277260	15/107 (14%)
		Hrs_helical	377..471	CDD:289018	17/110 (15%)
		GBP_C	<456..520	CDD:303769	4/73 (5%)
		coiled coil	501..512	CDD:293879	0/10 (0%)
Gga	NP_572571.1	VHS_GGA	7..144	CDD:239624	33/141 (23%)
		GAT	210..284	CDD:281166	12/81 (15%)
		Alpha_adaptinC2	543..644	CDD:197886	18/117 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840