Protein Alignment Hrs and Zfyve1

DIOPT Version :10

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_001421228.1
• Gene: Zfyve1 / 299188
• RGDID: 1307795
• Length: 788
• Species: Rattus norvegicus
• Alignment Length: 302
• Identity: 64/302 - (21%)
• Similarity: 101/302 - (33%)
• Gaps: 107/302 - (35%)

  Fly     3 RSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNP-----HSSCY- 61
            |.:.::.|||.|:.   .|..|.::.             .|..|:..:.:...|     |||.:
  Rat   375 RRALEQLLENNTTR---SPRHPGVIF-------------KALKALSDRFSGEIPDDQMAHSSFFP 423

  Fly    62 -SLLVLESIVKNCGAPV------------HE-------------EVFTKENC------------- 87
             ......|:..:|||..            ||             .|:|.:.|
  Rat   424 DEYFTCSSLCLSCGAGCKNSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGKEVSVVPKT 488

  Fly    88 -------------EMFSSFLESTPHENV----RQKML------------ELVQTW----AYAFRS 119
                         ..:|.::...|:..|    ||...            |:|..|    |:...:
  Rat   489 SASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDAFLKDN 553

  Fly   120 SDKYQAIKDTMTILKAKGHTFPEL-----READAMFTADTAP-NWADGR---VCHRCRVEFTFTN 175
            ::..|.:.|.|..:   ..:..||     :...:..|...|| .|....   .|::|...|...:
  Rat   554 NNAAQRLLDGMNFM---AQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNQCATSFKDND 615

  Fly   176 RKHHCRNCGQVFCGQCTAKQCPLPKYGI-EKEVRVCDGCFAA 216
            .|||||.||:.||..|::|..|:|:.|. ...|||||.|:.|
  Rat   616 TKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDNCYDA 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs	4..141	CDD:340771	33/214 (15%)
		FYVE_Hrs	157..217	CDD:277260	25/64 (39%)
		GAT_Hrs	376..471	CDD:410592
		PABP-1234	<501..641	CDD:130689
Zfyve1	NP_001421228.1	Bbox1_ZFYVE1_rpt1	16..63	CDD:380877
		Bbox1_ZFYVE1_rpt2	69..122	CDD:380878
		GBP	174..410	CDD:206650	9/50 (18%)
		FYVE_like_SF	594..655	CDD:333710	23/60 (38%)
		FYVE_ZFYV1	722..782	CDD:277273