Protein Alignment Hrs and GGA1

DIOPT Version :9

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_001350700.1
• Gene: GGA1 / 26088
• HGNCID: 17842
• Length: 656
• Species: Homo sapiens
• Alignment Length: 845
• Identity: 143/845 - (16%)
• Similarity: 256/845 - (30%)
• Gaps: 341/845 - (40%)

  Fly     5 SFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSS---------- 59
            :.:..:..||:.|..|.||.||...|:::|:....|..|...:..|:.||....:
Human     9 TLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWEAIQALTVRRGE 73

  Fly    60 -------CYSLLVLESIVKNCGAPVHEEV----FTKENCEMFS-SFLESTPHENVRQKMLELVQT 112
                   |....|||:.:|:||...|:||    |..|..::.| .:|.|...|.|:.|:|||:.:
Human    74 ATIRPPPCDDTKVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYS 138

  Fly   113 WAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRK 177
            |.
Human   139 WT--------------------------------------------------------------- 140

  Fly   178 HHCRNCGQVFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPR-PADSELPAE 241
                                   .|:.:||::.: .:..|::    .|..||.|: |.|:..|
Human   141 -----------------------VGLPEEVKIAE-AYQMLKK----QGIVKSDPKLPDDTTFP-- 175

  Fly   242 YLNSTLAQQVQTPARKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAP 306
                                                           ||               |
Human   176 -----------------------------------------------LP---------------P 178

  Fly   307 PEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSAD 371
            |.||....:.||.:. .||:.|..|:                               |..:::|:
Human   179 PRPKNVIFEDEEKSK-MLARLLKSSH-------------------------------PEDLRAAN 211

  Fly   372 EVQIDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMW 436
            ::        ::..|:....||:..|.|..:|...::...|...:...|||..:.....:|   .
Human   212 KL--------IKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSED---L 265

  Fly   437 YEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQL 501
            .::|..:..:::.:...|....:::.|.|..|.:..:     .:.|.:::          |::.:
Human   266 MKELYQRCERMRPTLFRLASDTEDNDEALAEILQAND-----NLTQVINL----------YKQLV 315

  Fly   502 ALQRIQEQEREMQLRQEQQKAQYLMGQSAPP----FPYMP----PSAVPQHGSPSHQLNN----- 553
            ..:.:........:.........|.|...||    :|.||    ..|.|:..|.|..|.:
Human   316 RGEEVNGDATAGSIPGSTSALLDLSGLDLPPAGTTYPAMPTRPGEQASPEQPSASVSLLDDELMS 380

  Fly   554 --VYNPYAAGVPGYLPQGPAPAPNGHGQFQAI----PPGMYNPAIQQ-----PMPP--------- 598
              :.:|    .|   |.||:....|...||:.    ||.   ||:.|     ..||
Human   381 LGLSDP----TP---PSGPSLDGTGWNSFQSSDATEPPA---PALAQAPSMESRPPAQTSLPASS 435

  Fly   599 -----NLQPGGLMQQPAPPGNPQM----MPPMPENQFAN--NPAAILQLPQQ------HSIA-QP 645
                 :|....|:||..||.:.|:    ..|.|.....:  |.::....|..      |::: :|
Human   436 GLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTPRLTLRDLQNKSSSCSSPSSSATSLLHTVSPEP 500

  Fly   646 PQIPFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPGQQPQQIPVQQPQPQPQMGHVMLQQH-- 708
            |:.|.||.|.::                         ......:|::..:|...:...:..||
Human   501 PRPPQQPVPTEL-------------------------SLASITVPLESIKPSNILPVTVYDQHGF 540

  Fly   709 -------QAPPAAQAPPVTEIANNQVQAVAAAPAPPQN------EPGPAPVKAEEPATAELISFD 760
                   :.|    .|..:::....|..::.||.|.:|      .|....||.:.|:..||.:|:
Human   541 RILFHFARDP----LPGRSDVLVVVVSMLSTAPQPIRNIVFQSAVPKVMKVKLQPPSGTELPAFN 601

  Fly   761  760
            Human   602  601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	37/159 (23%)
		FYVE_Hrs	157..217	CDD:277260	3/59 (5%)
		Hrs_helical	377..471	CDD:289018	16/93 (17%)
		GBP_C	<456..520	CDD:303769	5/63 (8%)
		coiled coil	501..512	CDD:293879	0/10 (0%)
GGA1	NP_001350700.1	VHS_GGA	9..164	CDD:239624	42/245 (17%)
		GAT_GGA1_GGA2	227..316	CDD:260097	15/106 (14%)
		Alpha_adaptinC2	534..648	CDD:197886	16/72 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910