DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hrs and GGA2

DIOPT Version :9

Sequence 1:	NP_525099.3	Gene:	Hrs / 33458	FlyBaseID:	FBgn0031450	Length:	760	Species:	Drosophila melanogaster
Sequence 2:	NP_055859.1	Gene:	GGA2 / 23062	HGNCID:	16064	Length:	613	Species:	Homo sapiens

Alignment Length:	768	Identity:	141/768 - (18%)
Similarity:	238/768 - (30%)	Gaps:	258/768 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLES 68
            :|.:..|..||.....|.||.:|...|:::|.....|.:|...:..|:.||....:.|:|.|||.
Human    24 ASLELWLNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEM 88

  Fly    69 IVKNCGAPVHEEV----FTKENCEMFS-SFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKD 128
            .:.:||...|.||    |..|..::.| .:|.|.....|:.:::|::.:|...|....|   |:|
Human    89 CMNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIK---IRD 150

  Fly   129 TMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTA 193
            ...:||.:|                                                      ..
Human   151 AYQMLKKQG------------------------------------------------------II 161

  Fly   194 KQCPLPKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPAD---SELPAEYLNSTLAQQVQTPA 255
            ||.  ||..::|          .|..|   |...||....||   |:|....|.|...:.:|...
Human   162 KQD--PKLPVDK----------ILPPP---SPWPKSSIFDADEEKSKLLTRLLKSNHPEDLQAAN 211

  Fly   256 RKTEQELKEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSPSPEAPPEPKEYHQQPEEAT 320
            |..:..:|||:|....::...|..|:.:..::.|                 .|....:::|.:|
Human   212 RLIKNLVKEEQEKSEKVSKRVSAVEEVRSHVKVL-----------------QEMLSMYRRPGQA- 258

  Fly   321 NPELAKYLNRSYWEQRKISESSSMASPSAPSPMPPTPQPQQIMPLQVKSADEVQIDEFAANMRTQ 385
                                             ||..:..|:            :.|....:|.
Human   259 ---------------------------------PPDQEALQV------------VYERCEKLRP- 277

  Fly   386 VEIFVNRMKSNSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDS 450
             .:|  |:.|:::     .:|.::..:......|....|.|.:.|:.:..:..::...|..|..|
Human   278 -TLF--RLASDTT-----DDDDALAEILQANDLLTQGVLLYKQVMEGRVTFGNRVTSSLGDIPVS 334

  Fly   451 RAALDQLRQEHVEKLRRIAEEQERQRQMQMAQKLDI-------MRKKKQEYLQYQRQLAL----- 503
            |..                  |.....|:....:|:       ........|.:|...||
Human   335 RVF------------------QNPAGCMKTCPLIDLEVDNGPAQMGTVVPSLLHQDLAALGISDA 381

  Fly   504 --------QRIQEQERE-----------MQLRQEQQKAQYLMGQSAP-PFPYMPPSAVPQHGSPS 548
                    |...|::|.           .....::.....|..|.|| |..|:...:||:...|.
Human   382 PVTGMVSGQNCCEEKRNPSSSTLPGGGVQNPSADRNLLDLLSAQPAPCPLNYVSQKSVPKEVPPG 446

  Fly   549 HQLNNVYNPYAAGVPGY-LPQGP-APAPNGHGQFQAIPPGMYNPAIQQPMPPNLQP------GGL 605
            .:.:          ||: ...|| ||:|:.    |..|.......::...|.:|.|      .|.
Human   447 TKSS----------PGWSWEAGPLAPSPSS----QNTPLAQVFVPLESVKPSSLPPLIVYDRNGF 497

  Fly   606 -----MQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQHSIAQPP-QIPFQ---PQPQQIPGQ- 660
                 ..|...||:|::.              :|.|....:..||. .|.||   |:..::..|
Human   498 RILLHFSQTGAPGHPEVQ--------------VLLLTMMSTAPQPVWDIMFQVAVPKSMRVKLQP 548

  Fly   661 -QPQQIPGQQPQQIPGQQPQQIPGQQPQQIPV---------QQPQPQPQMGHV 703
             ...::|...|...|....|.:....|.:.|:         |..||..::|.|
Human   549 ASSSKLPAFSPLMPPAVISQMLLLDNPHKEPIRLRYKLTFNQGGQPFSEVGEV 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	40/143 (28%)
		FYVE_Hrs	157..217	CDD:277260	5/59 (8%)
		Hrs_helical	377..471	CDD:289018	14/93 (15%)
		GBP_C	<456..520	CDD:303769	10/94 (11%)
		coiled coil	501..512	CDD:293879	4/23 (17%)
GGA2	NP_055859.1	VHS_GGA	25..163	CDD:239624	40/194 (21%)
		ATP-synt_B	168..>240	CDD:304375	20/84 (24%)
		GAT_GGA1_GGA2	227..315	CDD:260097	18/159 (11%)
		Unstructured hinge	316..483		32/198 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	389..414		3/24 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	435..466		10/40 (25%)
		Alpha_adaptinC2	491..605	CDD:197886	25/125 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910