DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hrs and Zfyve1

DIOPT Version :9

Sequence 1:NP_525099.3 Gene:Hrs / 33458 FlyBaseID:FBgn0031450 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_001346095.1 Gene:Zfyve1 / 217695 MGIID:3026685 Length:777 Species:Mus musculus


Alignment Length:302 Identity:64/302 - (21%)
Similarity:101/302 - (33%) Gaps:107/302 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 RSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNP-----HSSCY- 61
            |.:.::.|||.|:.   .|..|.::.             .|..|:..:.:...|     |||.: 
Mouse   375 RRALEQLLENNTTR---SPRHPGVIF-------------KALKALSDRFSGEIPDDQMAHSSFFP 423

  Fly    62 -SLLVLESIVKNCGAPV------------HE-------------EVFTKENC------------- 87
             ......|:..:|||..            ||             .|:|.:.|             
Mouse   424 DEYFTCSSLCLSCGAGCKNSMNHGKEGVPHEAKSRCRYSHQYDNRVYTCKACYERGKEVSVVPKT 488

  Fly    88 -------------EMFSSFLESTPHENV----RQKML------------ELVQTW----AYAFRS 119
                         ..:|.::...|:..|    ||...            |:|..|    |:...:
Mouse   489 SASTDSPWMGLAKYAWSGYVIECPNCGVVYRSRQYWFGNQDPVDTVVRTEIVHVWPGTDAFLKDN 553

  Fly   120 SDKYQAIKDTMTILKAKGHTFPEL-----READAMFTADTAP-NWADGR---VCHRCRVEFTFTN 175
            ::..|.:.|.|..:   ..:..||     :...:..|...|| .|....   .|::|...|...:
Mouse   554 NNAAQRLLDGMNFM---AQSVSELSLGPTKAVTSWLTDQIAPAYWRPNSQILSCNQCATSFKDND 615

  Fly   176 RKHHCRNCGQVFCGQCTAKQCPLPKYGI-EKEVRVCDGCFAA 216
            .|||||.||:.||..|::|..|:|:.|. ...|||||.|:.|
Mouse   616 TKHHCRACGEGFCDSCSSKTRPVPERGWGPAPVRVCDSCYDA 657

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HrsNP_525099.3 VHS_Hrs_Vps27p 2..143 CDD:239626 34/217 (16%)
FYVE_Hrs 157..217 CDD:277260 25/64 (39%)
Hrs_helical 377..471 CDD:289018
GBP_C <456..520 CDD:303769
coiled coil 501..512 CDD:293879
Zfyve1NP_001346095.1 Bbox1_ZFYVE1_rpt1 16..63 CDD:380877
Bbox1_ZFYVE1_rpt2 69..121 CDD:380878
GBP 174..410 CDD:206650 9/50 (18%)
Required for localization in the lipid droplets. /evidence=ECO:0000250|UniProtKB:Q9HBF4 416..777 54/245 (22%)
FYVE_like_SF 594..655 CDD:333710 23/60 (38%)
FYVE_ZFYV1 711..771 CDD:277273
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1818
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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