Protein Alignment Hrs and apt-9

DIOPT Version :9

• Sequence 1: NP_525099.3
• Gene: Hrs / 33458
• FlyBaseID: FBgn0031450
• Length: 760
• Species: Drosophila melanogaster
• Sequence 2: NP_509853.2
• Gene: apt-9 / 189194
• WormBaseID: WBGene00000166
• Length: 588
• Species: Caenorhabditis elegans
• Alignment Length: 575
• Identity: 111/575 - (19%)
• Similarity: 209/575 - (36%)
• Gaps: 162/575 - (28%)

  Fly    40 PKNAFAAI---KKKMNSPNPHSSCYSLLVLESIVKNCGAPVHEE-------------VFTKENCE 88
            |.:|..|:   ..|::||:...:..::..|:.:|:|.|..|||.             :..|.|.:
 Worm    41 PASALLAVDLFSHKLSSPSQEEAMLTIRALDYLVRNGGEKVHERCGRYKFLNELVRLIAPKYNGK 105

  Fly    89 MFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTILKAKGHTFPELREADAMFTAD 153
            :.|..|::        ::::|:..|..:.:...||:.:.:::.:.|..... |.:||.:
 Worm   106 LTSDALKT--------EIIKLLFIWQLSIKHIPKYKQVYESLKLSKIITDD-PHVRETE------ 155

  Fly   154 TAPNWADGRVCHRCRV-----------EFTFTNRKHHCRNCGQVFCGQCTAKQCPLPKY-----G 202
             .|.:|...|  |..|           ....:||.........:.......::..|.|.     .
 Worm   156 -VPVFAVPPV--RSSVFDNEEQAVLLKALLSSNRPEDLETANNLIKTLVETEEHKLVKIHERRKK 217

  Fly   203 IEKEVRVCDGC-FAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELKE-- 264
            ::..:.:|:.. ...|.:.....|.....|   |:||..:.:.:.|. |:|........||.|
 Worm   218 LDHAINLCNQVEHLRLDKAAETIGLGNYSP---DNELTLQRVTNELI-QLQELFYGYVNELAENN 278

  Fly   265 ----EEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQ----------RSPSPEAPP-----EPK 310
                ||.|.:...:::...|.:.||..:..|.:.|.|.          .:|:.|.||     :|:
 Worm   279 DPCLEEVLNINDQINRVLPENETPKCGNRAPISARTQLDPENQELLVFNTPTSEVPPKNGFCDPR 343

  Fly   311 -------------EYHQQPEEATNPELAKYLNRSYWEQRKISESSS------MASPSAPSPM-PP 355
                         |:.::|:.....::...|||:.....:.|..||      :|....|.|: ||
 Worm   344 DLEGSLLNNMIESEFVEEPKIVPVQQMTPVLNRNSSASPRASGDSSIFETDFLAGKRLPEPLKPP 408

  Fly   356 T------------------------PQPQQIMPLQVKSADEVQIDEFAANMRTQVEIFVNRMKSN 396
            |                        |:|..:.|..:  .::|.::..:..||.:|.|.|     .
 Worm   409 TLNELKPNTTTITLEALEVLVPPMSPEPTSLSPKAI--PEKVALNPSSIIMRNRVPIEV-----L 466

  Fly   397 SSRGRSI-----SNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQ 456
            .|:|..|     .:|       ||::::||..|..            |..:..| |||...:|..
 Worm   467 YSKGMRILLYYCQSD-------MTVSNIHSYVLVI------------QNHNNFT-IKDVNLSLKT 511

  Fly   457 ------LR-QEHVEKLR--RIAEEQERQRQMQMAQKLDIMRKKKQEY-LQYQRQL 501
                  :| |:.|..|.  .|..:||....:...|:|:.::..:.:: |.|::.|
 Worm   512 NDKNVIIRLQDSVNNLAGFNIFGQQETINLLLCIQQLNDVKDVELDFTLAYKKSL 566

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hrs	NP_525099.3	VHS_Hrs_Vps27p	2..143	CDD:239626	23/118 (19%)
		FYVE_Hrs	157..217	CDD:277260	9/76 (12%)
		Hrs_helical	377..471	CDD:289018	25/107 (23%)
		GBP_C	<456..520	CDD:303769	12/56 (21%)
		coiled coil	501..512	CDD:293879	1/1 (100%)
apt-9	NP_509853.2	VHS_ENTH_ANTH	8..147	CDD:295355	22/113 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910