DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hrs and hgrs-1

DIOPT Version :9

Sequence 1:NP_525099.3 Gene:Hrs / 33458 FlyBaseID:FBgn0031450 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_501375.2 Gene:hgrs-1 / 177617 WormBaseID:WBGene00004101 Length:729 Species:Caenorhabditis elegans


Alignment Length:837 Identity:285/837 - (34%)
Similarity:396/837 - (47%) Gaps:190/837 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLES 68
            :.|.:.|:.||....:||:|..|:|..|.|...:|..|.:..||:|:|...|||...::||||::
 Worm     3 TKFQRVLDQATDSTLVEPNWEGIILCTDMIRSGEVPAKPSLQAIRKRMQHENPHVVNHTLLVLDA 67

  Fly    69 IVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTIL 133
            .|||||..||.||.|:|..|.|.:.:....::.|:.|.||::|.||.||.:..:|:.:.||..::
 Worm    68 CVKNCGHKVHAEVATREFMEDFKNLVTENKYDEVKNKSLEMLQCWATAFANKPEYKMVVDTHNLM 132

  Fly   134 KAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPL 198
            |..|..||.|:||||||.|..||.||||..|:|||..|:...||||||.|||:||.:|::::..|
 Worm   133 KLAGFDFPSL
KEADAMFMAQVAPEWADGPECYRCRSVFSVFTRKHHCRACGQIFCDKCSSRELAL 197

  Fly   199 PKYGIEKEVRVCDGC-----------FAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQ 252
            |::|||||||||:.|           :.|:::....:.|.| |...||.....:.|..       
 Worm   198 PQFGIEKEVRVCETCYEKKVAEVKERYPAVKKQLDAAHGRK-GDSEADKAAKEKLLRE------- 254

  Fly   253 TPARKTEQELKEEEELQLALALSQSEAE-QQKPKLQSLPPAAYRMQQRSPSPE------------ 304
                      ||||:|.||:|:|||||| ::|.|..:|    |.| .....||            
 Worm   255 ----------KEEEDLALAIAISQSEAEAKEKEKQNNL----YSM-YNGIKPEVDGYKGAAEPVT 304

  Fly   305 APPEPKEYHQQPEEATNPELAKYLNRSYWEQRK------ISESSSMASPSAPSPMPPTPQPQQIM 363
            |||        |:::::..||:||||.||:|:|      .|..||..|.:||.|..|:..|....
 Worm   305 APP--------PDDSSSDPLARYLNRDYWQQKKEGKVEDWSSRSSALSATAPPPSEPSIAPSICS 361

  Fly   364 PLQ-------------------------VKSADEVQIDE---FAANMRTQVEIFVNRMKSNSSRG 400
            .|.                         |....::|.|:   :..::|.||.:..||::||.:||
 Worm   362 TLMGPDDNSLNADIAAMSLGGTNGLNGTVSDDAKLQADDTMKWCQSIREQVSVMDNRIRSNLARG 426

  Fly   401 RSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKL 465
            |.:.|||::|.||..||.|||..||.:..:|::|.:||.|||.|..|.::|.|:|::|:||..|.
 Worm   427 RPVFNDSAIQDLFTKLTELHSHVLSRMHTLDEQRGYYESLQDHLANIGEARQAIDEMREEHERKR 491

  Fly   466 R-RIAEEQERQRQMQMAQKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQY---LM 526
            : |:|||| |.||.||.|.|::||.||...|..||:.||||.|:|::||.:|:.||:|.|   .|
 Worm   492 QERMAEEQ-RLRQAQMQQTLEMMRMKKHAMLMEQREQALQRFQQQQQEMAMRRHQQQAYYNPQQM 555

  Fly   527 GQSAPPFPYMPPSAVPQHGSPSHQLNNVYNPYAAGVPGYLPQGPAPAPNGHGQFQAIPPGMYNPA 591
            |..|||                                  |.||                     
 Worm   556 GYGAPP----------------------------------PSGP--------------------- 565

  Fly   592 IQQPMPPNLQPGGLMQQPAPPGNPQMMPPMPENQFANNPAAILQLPQQH--------SIAQPPQI 648
             ||  ||.....|..|      .||...|.|.:|:..:.|:..|..||:        ::.||.|.
 Worm   566 -QQ--PPQQSYYGYQQ------GPQSQAPPPSSQYQQSHASTQQQQQQYYQHYQANQTVTQPVQQ 621

  Fly   649 PFQPQPQQIPGQQPQQIPGQQPQQIPGQQPQQIP----------GQQPQQIPVQQPQPQPQMGHV 703
            ..|...||..|...||.|.|  ||...|.|||..          ||..||...:..|.....|: 
 Worm   622 AQQQYQQQYQGYYQQQQPYQ--QQAGYQNPQQHQNYQNGTTNENGQYQQQQSSEVKQEHQNHGY- 683

  Fly   704 MLQQHQAPPAAQAPPVTEIANNQVQAVAAAPAPPQNEPGPAPVKAEEPATAELISFD 760
            ..||.|.|||:       :|:|.............:.....|..||:|    |||||
 Worm   684 QQQQAQHPPAS-------VASNGHNGYGNVDQNAHHHQQQQPQIAEQP----LISFD 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HrsNP_525099.3 VHS_Hrs_Vps27p 2..143 CDD:239626 53/138 (38%)
FYVE_Hrs 157..217 CDD:277260 33/70 (47%)
Hrs_helical 377..471 CDD:289018 41/97 (42%)
GBP_C <456..520 CDD:303769 32/64 (50%)
coiled coil 501..512 CDD:293879 6/10 (60%)
hgrs-1NP_501375.2 VHS_Hrs_Vps27p 1..142 CDD:239626 53/138 (38%)
FYVE_Hrs 156..215 CDD:277260 33/58 (57%)
Hrs_helical 403..497 CDD:289018 40/93 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160159468
Domainoid 1 1.000 104 1.000 Domainoid score I4193
eggNOG 1 0.900 - - E1_KOG1818
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37954
Inparanoid 1 1.050 389 1.000 Inparanoid score I1141
Isobase 1 0.950 - 0.811278 Normalized mean entropy S3060
OMA 1 1.010 - - QHG45851
OrthoDB 1 1.010 - - D334336at33208
OrthoFinder 1 1.000 - - FOG0005737
OrthoInspector 1 1.000 - - oto18914
orthoMCL 1 0.900 - - OOG6_106317
Panther 1 1.100 - - LDO PTHR46275
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1647
SonicParanoid 1 1.000 - - X4133
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1716.790

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