DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hrs and Hgs

DIOPT Version :9

Sequence 1:NP_525099.3 Gene:Hrs / 33458 FlyBaseID:FBgn0031450 Length:760 Species:Drosophila melanogaster
Sequence 2:XP_030101450.1 Gene:Hgs / 15239 MGIID:104681 Length:807 Species:Mus musculus


Alignment Length:857 Identity:352/857 - (41%)
Similarity:461/857 - (53%) Gaps:161/857 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMNSPNPHSSCYSLLVLES 68
            |:.||    |||.|.||.||.|||.|||.|.|.|...|.|..:||||:|..|||.:.|:|.|:||
Mouse    12 STSDK----ATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEVMES 72

  Fly    69 IVKNCGAPVHEEVFTKENCEMFSSFLESTPHENVRQKMLELVQTWAYAFRSSDKYQAIKDTMTIL 133
            :|||||..||:||..|:..|.....|:.....|||.|:|.|:|.||:|||:..||:.::||..|:
Mouse    73 VVKNCGQTVHDEVANKQTMEELKELLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKVVQDTYQIM 137

  Fly   134 KAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQVFCGQCTAKQCPL 198
            |.:||.|||.:|:||||.|:.||:|.|...||||||:|....||||||.|||:|||:|::|...:
Mouse   138 KVEGHVFPEFKESDAMFAAERAPDWVDAEECHRCRVQFGVVTRKHHCRACGQIFCGKCSSKYSTI 202

  Fly   199 PKYGIEKEVRVCDGCFAALQRPTSGSGGAKSGPRPADSELPAEYLNSTLAQQVQTPARKTEQELK 263
            ||:|||||||||:.|:..|.:...|...       :.:|||.|||.|.|:||.|.|.::.|..|:
Mouse   203 PKFGIEKEVRVCEPCYEQLNKKAEGKAS-------STTELPPEYLTSPLSQQSQLPPKRDETALQ 260

  Fly   264 EEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQRSP-SPEAPPEPKEYHQ------QPE---- 317
            |||||||||||||||||:::...|.....|:...:.:| :..|||....|..      .|:    
Mouse   261 EEEELQLALALSQSEAEEKERMRQKTTYTAHPKAEPTPLASSAPPAGSLYSSPVTQCLSPQNSSA 325

  Fly   318 ---EATNPELAKYLNRSYWEQRKISESSSMASPSAPSPM-PPTPQP------------------- 359
               |..:||||:||||:||| :|..|:....:||||.|: .|..||                   
Mouse   326 PLAEDIDPELARYLNRNYWE-KKQEEARKSPTPSAPVPLTEPAAQPGEGHTAPNSMAEAPLPETD 389

  Fly   360 -QQIMPLQVKSADEVQ-------IDEFAANMRTQVEIFVNRMKSNSSRGRSISNDSSVQTLFMTL 416
             |.|.|.....:::.|       .::|...::..|..||||||||..|||||:|||:|.:||.::
Mouse   390 SQPITPCSGPFSEQYQNGESEESHEQFLKALQNAVSTFVNRMKSNHMRGRSITNDSAVLSLFQSI 454

  Fly   417 TSLHSQQLSYIKEMDDKRMWYEQLQDKLTQIKDSRAALDQLRQEHVEKLRRIAEEQERQRQMQMA 481
            .::|.|.|..:.::|::|::||.|||||.||:|:|.||..||:||.|||||.|||.|||||:|:|
Mouse   455 NTMHPQLLELLNQLDERRLYYEGLQDKLAQIRDARGALSALREEHREKLRRAAEEAERQRQIQLA 519

  Fly   482 QKLDIMRKKKQEYLQYQRQLALQRIQEQEREMQLRQEQQKAQYLMGQSAP--PFPYMPPSAVPQH 544
            |||:|||:||||||:.|||||:||:||||:|.|:|.||||....|....|  |.||....|:|..
Mouse   520 QKLEIMRQKKQEYLEVQRQLAIQRLQEQEKERQMRLEQQKQTVQMRAQMPAFPLPYAQLQAMPTA 584

  Fly   545 GSPSHQLNN------VYNPYAAGVPG------YLPQGPAPAPNGHGQFQAIPPGMYNPAI----- 592
            |...:|.:.      .::| |..|.|      |:.| ||||.   |.:.::|....:|::     
Mouse   585 GGVLYQPSGPTSFPATFSP-AGSVEGSPMHGVYMSQ-PAPAT---GPYPSMPGTTADPSMVSAYM 644

  Fly   593 ------------QQPMPPNLQPGGLMQQPAP-PG-------NPQMMPPMPENQFANNPAAILQLP 637
                        |....|...|.....||.| ||       .||.:|            ||.|.|
Mouse   645 YPTGAPGAQAAPQAQAGPTTSPAYSSYQPTPTPGYQSVASQAPQSLP------------AISQPP 697

  Fly   638 QQHSI----AQPPQIPFQPQPQQIPG------------QQPQQIPGQQPQQIPGQQPQQIPGQQP 686
            |..:|    :||..:.:||...| ||            :.|...|......:|||. ..:|.|||
Mouse   698 QTSNIGYMGSQPMSMGYQPYNMQ-PGGSVCVWSQITQCRAPSYFPQNLMTALPGQD-ASLPAQQP 760

  Fly   687 QQIPVQQPQPQPQMGHVMLQQHQAP---PAAQAPPVTEIANNQVQAVAAAPAPPQNEPGPAPVKA 748
             .||.|||          |.|..||   |..|.|||            |.|||.|   || |.:.
Mouse   761 -YIPGQQP----------LYQQMAPSTGPPQQQPPV------------AQPAPTQ---GP-PAQG 798

  Fly   749 EEPATAELISFD 760
            .|   |:|||||
Mouse   799 SE---AQLISFD 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HrsNP_525099.3 VHS_Hrs_Vps27p 2..143 CDD:239626 69/138 (50%)
FYVE_Hrs 157..217 CDD:277260 35/59 (59%)
Hrs_helical 377..471 CDD:289018 49/93 (53%)
GBP_C <456..520 CDD:303769 46/63 (73%)
coiled coil 501..512 CDD:293879 8/10 (80%)
HgsXP_030101450.1 VHS_Hrs 15..145 CDD:340771 66/133 (50%)
FYVE_Hrs 161..221 CDD:277260 35/59 (59%)
DNA_S_dndD <207..>546 CDD:274475 153/346 (44%)
Hrs_helical 415..509 CDD:371964 49/93 (53%)
MAP7 <500..>567 CDD:368554 46/66 (70%)
PAT1 <547..>701 CDD:370676 47/170 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167837271
Domainoid 1 1.000 133 1.000 Domainoid score I5064
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H37954
Inparanoid 1 1.050 545 1.000 Inparanoid score I1144
Isobase 1 0.950 - 0.811278 Normalized mean entropy S3060
OMA 1 1.010 - - QHG45851
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0005737
OrthoInspector 1 1.000 - - oto93664
orthoMCL 1 0.900 - - OOG6_106317
Panther 1 1.100 - - LDO PTHR46275
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1647
SonicParanoid 1 1.000 - - X4133
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.880

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