DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hrs and TOM1L2

DIOPT Version :9

Sequence 1:NP_525099.3 Gene:Hrs / 33458 FlyBaseID:FBgn0031450 Length:760 Species:Drosophila melanogaster
Sequence 2:NP_001337261.1 Gene:TOM1L2 / 146691 HGNCID:11984 Length:536 Species:Homo sapiens


Alignment Length:567 Identity:130/567 - (22%)
Similarity:198/567 - (34%) Gaps:163/567 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 FRSSFDKNLENATSHLRLEPDWPSILLICDEINQKDVTPKNAFAAIKKKMN-SPNPHSSCYSLLV 65
            |.:...:.||.||.......||...:.|||.||:.:..||:|..|:||::| :.|......:|.|
Human     9 FSTPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNRNYREVMLALTV 73

  Fly    66 LESIVKNCGAPVHEEVFTKENCEMFSSFLES------TPHEN----VRQKMLELVQTWAYAFRSS 120
            ||:.|||||...|..|..::       |::|      :|..|    |:.|:|.|:|.||.|||||
Human    74 LETCVKNCGHRFHILVANRD-------FIDSVLVKIISPKNNPPTIVQDKVLALIQAWADAFRSS 131

  Fly   121 DKYQAIKDTMTILKAKGHTFPELREADAMFTADTAPNWADGRVCHRCRVEFTFTNRKHHCRNCGQ 185
            .....:......||.||..|| :.:.||:                                    
Human   132 PDLTGVVHIYEELKRKGVEFP-MADLDAL------------------------------------ 159

  Fly   186 VFCGQCTAKQCPLPKYGIEKEVRVCDGCFAALQRPTS---GSGGAKSGPRPADSELP-AEYLNST 246
                        .|.:..::.|...|.. |.:.|..|   .|.|:.|.|.||....| |..|:.|
Human   160 ------------SPIHTPQRSVPEVDPA-ATMPRSQSQQRTSAGSYSSPPPAPYSAPQAPALSVT 211

  Fly   247 ---LAQQVQTPARKTEQEL-----KEEEELQLALALSQSEAEQQKPKLQSLPPAAYRMQQR---- 299
               .|...|....::|.::     |...|:...:...|.::...: .||.|......||||    
Human   212 GPITANSEQIARLRSELDVVRGNTKVMSEMLTEMVPGQEDSSDLE-LLQELNRTCRAMQQRIVEL 275

  Fly   300 --SPSPEAPPEPKEYHQQPEEATNPELAKYLNRSYWEQRKISESSS---------------MASP 347
              ..|.|...|  |.....::..|..|.......|...|.:..:|:               ..||
Human   276 ISRVSNEEVTE--ELLHVNDDLNNVFLRYERFERYRSGRSVQNASNGVLNEVTEDNLIDLGPGSP 338

  Fly   348 SAPSPM-----PPTPQPQQIMPLQVKSADEVQ--------------IDEFA-------ANMRTQV 386
            :..|||     ||:....|:..|.: ..:.|.              .|.||       |..|..|
Human   339 AVVSPMVGNTAPPSSLSSQLAGLDL-GTESVSGTLSSLQQCNPRDGFDMFAQTRGNSLAEQRKTV 402

  Fly   387 ------------EIFVNRMKS------NSSRGRSISNDSSVQTLFMTLTSLHSQQLSYIKEMDDK 433
                        ....||.:|      :|::.|....:|.::.:...|.:.....::....|||.
Human   403 TYEDPQAVGGLASALDNRKQSSEGTFLSSAQKRGRGGESDLEPIDSWLITQGMIPVAQPSVMDDI 467

  Fly   434 RMWYEQLQDKLTQIKDSRAALDQLRQEHV--EKLRRIAEEQERQRQM 478
            .:|..      |.:|.     |.| :|.|  |:..:..||:.:..:|
Human   468 EVWLR------TDLKG-----DDL-EEGVTSEEFDKFLEERAKAAEM 502

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HrsNP_525099.3 VHS_Hrs_Vps27p 2..143 CDD:239626 53/151 (35%)
FYVE_Hrs 157..217 CDD:277260 4/59 (7%)
Hrs_helical 377..471 CDD:289018 23/120 (19%)
GBP_C <456..520 CDD:303769 7/25 (28%)
coiled coil 501..512 CDD:293879
TOM1L2NP_001337261.1 VHS_Tom1L2 12..148 CDD:340793 48/142 (34%)
GAT_TM1L2 218..309 CDD:260096 18/93 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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