DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment map4k5 and Pak

DIOPT Version :9

Sequence 1:	XP_021336201.1	Gene:	map4k5 / 334565	ZFINID:	ZDB-GENE-030131-6497	Length:	894	Species:	Danio rerio
Sequence 2:	NP_001138013.2	Gene:	Pak / 44039	FlyBaseID:	FBgn0267698	Length:	840	Species:	Drosophila melanogaster

Alignment Length:	273	Identity:	112/273 - (41%)
Similarity:	164/273 - (60%)	Gaps:	9/273 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish    15 NPQHDFELIQRVGSGTYGDVYKARKISTGELAAVKIIKLEPGDDFSIIQQEIFMVKECTHHNIVA 79
            :|...:..::::|.|..|.||.|.:.|||...|:|.:.|.......:|..||.:::|..|.|:|.
  Fly   561 DPNRKYTKMEKIGQGASGTVYTAIESSTGMEVAIKQMNLSQQPKKELIINEILVMRENKHPNVVN 625

Zfish    80 YFGSYLCREKLWICMEYCGGGSLQDIYHVTGPLSELQIAYVCRETLQGLGYLHSKGKMHRDIKGA 144
            |..|||..|:||:.|||..||||.|:...| .:.|.|||.||||.||.|.:||:...:|||||..
  Fly   626 YLDSYLVSEELWVVMEYLPGGSLTDVVTET-CMDEGQIAAVCREVLQALEFLHANQVIHRDIKSD 689

Zfish   145 NILLTDNGDVKLADFGVAAKITATMAKRKSFIGTPYWMAPEVAAVEKNGGYNHLCDIWAVGITSI 209
            ||||..:|.|||.|||..|:|:...:||.:.:||||||||||...::   |....|:|::||.:|
  Fly   690 NILLGLDGSVKLTDFGFCAQISPEQSKRTTMVGTPYWMAPEVVTRKQ---YGPKVDLWSLGIMAI 751

Zfish   210 ELAELQPPMFDLHPMRALFLMSKSNFQPPKLKDKTKWSTAFHNFVKLSLTKNPKRRPTAEKMLSH 274
            |:.|.:||..:.:|::||:|::.:.  .|::|:|.|.|:||.:|:...|.....||.:|..:|.|
  Fly   752 EMVEGEPPYLNENPLKALYLIATNG--KPEIKEKDKLSSAFQDFLDQCLEVEVDRRASALDLLKH 814

Zfish   275 LFVGQTGLTRRLA 287
            .|:   .|.|.||
  Fly   815 PFL---KLARPLA 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
map4k5	XP_021336201.1	STKc_MAP4K5	10..277	CDD:270813	107/261 (41%)
map4k5	XP_021336201.1	CNH	559..874	CDD:214481
Pak	NP_001138013.2	PBD	83..137	CDD:279166
		STKc_PAK_I	558..818	CDD:270814	108/265 (41%)
		S_TKc	566..817	CDD:214567	106/256 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910