DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and TMTC4

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001337500.1	Gene:	TMTC4 / 84899	HGNCID:	25904	Length:	818	Species:	Homo sapiens

Alignment Length:	912	Identity:	261/912 - (28%)
Similarity:	382/912 - (41%)	Gaps:	248/912 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPLANLLRNDFWGTPLVDSGSHGSWRPLCVLSF 92
            ::|.|.:..:.:..||:||..||:.|.|:....||.:|..:||||:.|..:.||.|:|||.||:|
Human    47 SVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTF 111

  Fly    93 RLN-YLAGGMTPLGYHLVNVMLHCVATWL---VFLV-----------ARTLLPSRMGVLAAGALF 142
            |:| ||:||..|:|:|:||::||...:.|   ||.|           .|..|..|..:||| .||
Human   112 RINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAA-LLF 175

  Fly   143 AVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRR--HMLNRE-------WGSLILTIMLALAALL 198
            ||||.|||.|||:||||||...:.:||::|.|.:  ...|:|       |  ::|:|.|...|:|
Human   176 AVHPVHTECVAGVVGRADLLCALFFLLSFLGYCKAFRESNKEGAHSSTFW--VLLSIFLGAVAML 238

  Fly   199 CKETAITAL-------------------LLCGLCDVLS-PVGRENS------------------- 224
            |||..||.|                   ||..:|...| ||...:|
Human   239 CKEQGITVLSCKLIEVAVLHTTALPGKGLLSSMCGFQSHPVHLHSSQLEGETKWECVPKFYNQTS 303

  Fly   225 ----DKVCDGSISGLASFN-------FQRRFRSLSILG----------FTLLCG-----LYCRLS 263
                :.|.|  |..:..||       ...:.:||..||          .|||..     ||.|..
Human   304 KMGLNAVFD--ILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWR 366

  Fly   264 LLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDAR 328
            ::.....||:..|||.:.......|.:.:.|....|..:||.|..|.|||.|..:..|:::.|.|
Human   367 IMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWR 431

  Fly   329 NILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDCHHQLSA 393
            .|..|..:..|:                                         ||.|
Human   432 VIALAALWFCLI-----------------------------------------GLIC-------- 447

  Fly   394 PSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGYCLL 458
                  .|:.|.....:...     .||..|||:||||||||.|.||||:|||||||||||||:|
Human   448 ------QALCSEDGHKRRIL-----TLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSVGYCVL 501

  Fly   459 FGLGFGHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFR---RNLDWRDEEQLFRSAISINPPKA 520
            ...|||.|.:...   :.:|:    .|::||:..:.|.|   |:.:||.||||||||:|:.|
Human   502 LTFGFGALSKHTK---KKKLI----AAVVLGILFINTLRCVLRSGEWRSEEQLFRSALSVCP--- 556

  Fly   521 LGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQL 585
                   |:|:                      .|:|:|.....:.|.::||..:|.|:.|.|:.
Human   557 -------LNAK----------------------VHYNIGKNLADKGNQTAAIRYYREAVRLNPKY 592

  Fly   586 AVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVRDRGAHVEARYTCYLQLSVLYRSDGRLQD 650
            ..|..||| :::...:..|||..:|....:::    .|..|       .::.|.::..|..|.:.
Human   593 VHAMNNLG-NILKERNELQEAEELLSLAVQIQ----PDFAA-------AWMNLGIVQNSLKRFEA 645

  Fly   651 AAAALRESLKALPLLPQKQRAVLHLRLGEILAELQDWNEAEHQQRLAMQLQPEQGAAYVTYGQTL 715
            |..:.|.::|.....|.     .:..||.:.|:|....:|.:..|.|..|:||...|:... ..|
Human   646 AEQSYRTAIKHRRKYPD-----CYYNLGRLYADLNRHVDALNAWRNATVLKPEHSLAWNNM-IIL 704

  Fly   716 ARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEALGLRLRAAALAPQDYTLQSCV 780
            ..|...||:||:..:.||:                                  |.|.|::|...:
Human   705 LDNTGNLAQAEAVGREALE----------------------------------LIPNDHSLMFSL 735

  Fly   781 ADALRLLNRLAEAELWYRKAVTLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGHAISR 845
            |:.|....:..|:|..:.||:...|.||..|.||..:....|....|...|..:|:|.|..:.::
Human   736 ANVLGKSQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGHLDLAKKHYEISLQLDPTASGTK 800

  Fly   846 AN 847
            .|
Human   801 EN 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	20/67 (30%)
		TPR_11	518..583	CDD:290150	11/64 (17%)
		TPR repeat	518..546	CDD:276809	2/27 (7%)
		TPR repeat	551..581	CDD:276809	8/29 (28%)
		TPR_1	552..584	CDD:278916	9/31 (29%)
		TPR	565..841	CDD:223533	65/275 (24%)
		TPR repeat	586..611	CDD:276809	7/24 (29%)
		TPR repeat	634..660	CDD:276809	5/25 (20%)
		TPR repeat	671..699	CDD:276809	7/27 (26%)
		TPR repeat	704..735	CDD:276809	9/30 (30%)
		TPR repeat	740..768	CDD:276809	0/27 (0%)
		TPR repeat	773..803	CDD:276809	8/29 (28%)
		TPR	808..841	CDD:197478	10/32 (31%)
		TPR repeat	808..836	CDD:276809	7/27 (26%)
TMTC4	NP_001337500.1	DUF1736	369..443	CDD:369859	21/73 (29%)
		TPR	558..794	CDD:223533	68/309 (22%)
		TPR repeat	559..587	CDD:276809	9/49 (18%)
		TPR repeat	592..622	CDD:276809	8/30 (27%)
		TPR repeat	627..655	CDD:276809	6/34 (18%)
		TPR repeat	661..687	CDD:276809	7/30 (23%)
		TPR repeat	695..723	CDD:276809	8/28 (29%)
		TPR repeat	728..758	CDD:276809	8/29 (28%)
		TPR repeat	763..791	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820