DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31690 and TMTC1

DIOPT Version :9

Sequence 1:	NP_995615.2	Gene:	CG31690 / 33455	FlyBaseID:	FBgn0051690	Length:	859	Species:	Drosophila melanogaster
Sequence 2:	NP_001354804.1	Gene:	TMTC1 / 83857	HGNCID:	24099	Length:	944	Species:	Homo sapiens

Alignment Length:	1026	Identity:	295/1026 - (28%)
Similarity:	427/1026 - (41%)	Gaps:	287/1026 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TPKCRR-----PSMSATLSHKDLAGLAGCSALAFVLYLNTLNAGFVYDDRRAILANGDVTGARPL 62
            ||..||     |:.:|.|       |||.|.|.   |..:|...||:||..||:.|.||....||
Human    15 TPSRRRGCGLAPAGAAAL-------LAGASCLC---YGRSLQGEFVHDDVWAIVNNPDVRPGAPL 69

  Fly    63 A-NLLRNDFWGTPLVDSGSHGSWRPLCVLSFRLNYLAGGMTPLGYHLVNVMLHCVATW-LVFLVA 125
            . .:..|||||..:.::.||.|:||||||:|:||....||.|..:|.||::|||:.|. |::...
Human    70 RWGIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNIFLTGMNPFYFHAVNIILHCLVTLVLMYTCD 134

  Fly   126 RTLLPSRMGVLAAGALFAVHPAHTEAVAGLVGRADLASCVCYLLAYLSYRRHMLNREWGS----- 185
            :|:..:|........||||||.|||||||:|||||:.:|:.:|||:|||.|.:.....|.
Human   135 KTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRADVLACLLFLLAFLSYNRSLDQGCVGGSFPST 199

  Fly   186 -----LILTIMLALAALLCKETAITALLLCGLCDVLSPVGRENSDKVCDGSI------------- 232
                 |:|::.|...|:|.|||.||...:|.:.|:.|...::  ||..:|::
Human   200 VSPFFLLLSLFLGTCAMLVKETGITVFGVCLVYDLFSLSNKQ--DKSSNGALCPRSPQQPGSPQP 262

  Fly   233 ------------------------------------SGL---------------ASFNFQRRF-- 244
                                                ||.               ||.|  |.|
Human   263 SSLPGHPHRENGKQQRFPHKGAWGGCHSPLPPEPKSSGFPVSPRAVWSMMRYLRASSN--RNFLL 325

  Fly   245 -------RSLSILGFTLLCGLYCRLSLLPRPSTAFSAADNPTAHESCFWTRTLTFLYLPVANFGI 302
                   |::.:|.:.|:. ||.||.::......||..|||.:......||.||:.||...|..:
Human   326 TMRPFLKRAILVLSYVLVI-LYFRLWIMGGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWL 389

  Fly   303 LLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAASPMDFAEVANISLP 367
            ||.|..|.:||.:.::..:.|:||.||:.|. |...::|:|    .|...|:
Human   390 LLAPVTLCYDWQVGSIPLVETIWDMRNLATI-FLAVVMALL----SLHCLAA------------- 436

  Fly   368 LLRRLGGNSCHTWLGLTCDCHHQLSAPSYRSASAIYSTSSKSKSASWTAAPILGTAFLVLPFLPA 432
             .:||.              |.::                           ::|..|||.||:||
Human   437 -FKRLE--------------HKEV---------------------------LVGLLFLVFPFIPA 459

  Fly   433 SNLLFYVGFVMAERVLYLPSVGYCLLFGLGFGHLWQRVNSSWRSR---LMLLCGLALLLGVHGVR 494
            |||.|.||||:||||||:||:|||:||..|...|     .:|.:|   ..|:....|||.:...:
Human   460 SNLFFRVGFVVAERVLYMPSMGYCILFVHGLSKL-----CTWLNRCGATTLIVSTVLLLLLFSWK 519

  Fly   495 TFRRNLDWRDEEQLFRSAISINP--PKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFN 557
            |.::|..|...|.||||.:...|  .|...|..:.|..|||.:||....|..|...|..|.|..|
Human   520 TVKQNEIWLSRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNN 584

  Fly   558 LGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAISVLRTGARLEGSGVR 622
            ||.:.:   :.:.|...::||::|.||...|..||| :|:...:.::|||::|:...:. |....
Human   585 LGTLTR---DTAEAKMYYQRALQLHPQHNRALFNLG-NLLKSQEKKEEAITLLKDSIKY-GPEFA 644

  Fly   623 DRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALRESLKALPLLPQKQRAVLHLRLGEILAE--LQ 685
            |          .|..|:.|.....|.::|....:..:|..|     ..:.||...|..|.:  |.
Human   645 D----------AYSSLASLLAEQERFKEAEEIYQTGIKNCP-----DSSDLHNNYGVFLVDTGLP 694

  Fly   686 DWNEAEHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFL 750
            :...|.:||  |::|.|....|.|..|: |.|:....:.||.|:|||||:|        |.|:.|
Human   695 EKAVAHYQQ--AIKLSPSHHVAMVNLGR-LYRSLGENSMAEEWYKRALQVA--------HKAEIL 748

  Fly   751 E-------QQERHHEALGLRLRAAALAPQDYTLQSCVADALRLLNRLAEAELW------------ 796
            .       ...|:.|||.:...||||.|....|:..:|..|.::.:..|||..
Human   749 SPLGALYYNTGRYEEALQIYQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCL 813

  Fly   797 ------------------------------------------------------------YRKAV 801
                                                                        ||.||
Human   814 ECYRLLSAIYSKQENHDKALDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAV 878

  Fly   802 TLQPMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGHAISRANLARMN 852
            .|.|..|.|..|:|.|..::|....|.|.|.:||:|.|...:.:.|||:::
Human   879 QLNPDQAQAWMNMGGIQHIKGKYVSARAYYERALQLVPDSKLLKENLAKLD 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31690	NP_995615.2	DUF1736	272..340	CDD:285594	25/67 (37%)
		TPR_11	518..583	CDD:290150	20/64 (31%)
		TPR repeat	518..546	CDD:276809	9/27 (33%)
		TPR repeat	551..581	CDD:276809	8/29 (28%)
		TPR_1	552..584	CDD:278916	9/31 (29%)
		TPR	565..841	CDD:223533	86/356 (24%)
		TPR repeat	586..611	CDD:276809	8/24 (33%)
		TPR repeat	634..660	CDD:276809	5/25 (20%)
		TPR repeat	671..699	CDD:276809	9/29 (31%)
		TPR repeat	704..735	CDD:276809	12/30 (40%)
		TPR repeat	740..768	CDD:276809	8/34 (24%)
		TPR repeat	773..803	CDD:276809	10/101 (10%)
		TPR	808..841	CDD:197478	13/32 (41%)
		TPR repeat	808..836	CDD:276809	10/27 (37%)
TMTC1	NP_001354804.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820