Protein Alignment Tmtc1 and ODAD4

DIOPT Version :10

• Sequence 1: NP_995615.2
• Gene: Tmtc1 / 33455
• FlyBaseID: FBgn0051690
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_113609.1
• Gene: ODAD4 / 83538
• HGNCID: 25280
• Length: 672
• Species: Homo sapiens
• Alignment Length: 234
• Identity: 56/234 - (23%)
• Similarity: 88/234 - (37%)
• Gaps: 69/234 - (29%)

  Fly   644 SDGRLQDAAAALRESLK-ALPLLPQKQRAV---------LHLRLGEILAELQDWNEAEHQQRLAM 698
            ::|.||.|...|::.|: ....:|.|...|         ..:.||::.|.||     .|::.|.:
Human   290 AEGSLQKAEKVLKKVLEWNKEEVPNKDELVGNLYSCIGNAQIELGQMEAALQ-----SHRKDLEI 349

  Fly   699 ----QLQPEQGAAYVTYGQTLARNGSRLAEAESWFKRALQLAPLEPSSHHHYADFLEQQERHHEA 759
                .|...:..|....|:..||.|......::|.::    .||..::       ||:....||
Human   350 AKEYDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEK----IPLAKTT-------LEKTWLFHE- 402

  Fly   760 LG---LRLRAAALAPQDY--TLQSCVADALRLLNRLAEAEL-WYRKAVTLQPMAAHAHANLGAIL 818
            :|   |.|..|..| |:|  ..|.|..:         |.:: |...|..|...|.         :
Human   403 IGRCYLELDQAWQA-QNYGEKSQQCAEE---------EGDIEWQLNASVLVAQAQ---------V 448

  Fly   819 QMRGLRKEAVACYHKALELQPGHAISRANLARMNVHKHE 857
            ::|.. :.||..:.||||        ||.|    ||.:|
Human   449 KLRDF-ESAVNNFEKALE--------RAKL----VHNNE 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc1	NP_995615.2	ArnT	11..>209	CDD:441412
		TMTC_DUF1736	271..340	CDD:462468
		PilF	501..585	CDD:442297
		TPR repeat	518..546	CDD:276809
		TPR repeat	551..581	CDD:276809
		LapB	556..838	CDD:442196	50/213 (23%)
		TPR repeat	586..611	CDD:276809
		TPR repeat	634..660	CDD:276809	5/15 (33%)
		TPR repeat	671..699	CDD:276809	8/40 (20%)
		TPR repeat	704..735	CDD:276809	6/30 (20%)
		TPR repeat	740..768	CDD:276809	7/30 (23%)
		TPR repeat	773..803	CDD:276809	6/32 (19%)
		TPR repeat	808..836	CDD:276809	5/27 (19%)
ODAD4	NP_113609.1	TPR 1. /evidence=ECO:0000255	13..46
		TPR	15..>113	CDD:440225
		TPR repeat	16..41	CDD:276809
		TPR repeat	46..76	CDD:276809
		TPR 2. /evidence=ECO:0000255	48..80
		TPR 3. /evidence=ECO:0000255	81..114
		TPR repeat	81..109	CDD:276809
		TPR 4. /evidence=ECO:0000255	275..311		6/20 (30%)
		TPR	<292..495	CDD:440225	56/232 (24%)
		TPR repeat	311..349	CDD:276809	10/42 (24%)
		TPR 5. /evidence=ECO:0000255	320..353		7/37 (19%)
		TPR 6. /evidence=ECO:0000255	360..393		8/36 (22%)
		TPR repeat	360..385	CDD:276809	6/24 (25%)
		TPR 7. /evidence=ECO:0000255	397..430		11/43 (26%)
		TPR repeat	431..465	CDD:276809	9/43 (21%)
		TPR 8. /evidence=ECO:0000255	437..470		13/54 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	527..672