DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc1 and KDM6A

DIOPT Version :10

Sequence 1:NP_995615.2 Gene:Tmtc1 / 33455 FlyBaseID:FBgn0051690 Length:859 Species:Drosophila melanogaster
Sequence 2:NP_001406738.1 Gene:KDM6A / 7403 HGNCID:12637 Length:1489 Species:Homo sapiens


Alignment Length:540 Identity:108/540 - (20%)
Similarity:179/540 - (33%) Gaps:157/540 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   184 GSLILTIMLALAALLCKETAITALLLCGLCDVLSP-VGRENSDKVCDGSISGLAS--FNFQR--- 242
            |..:.|...|.||...:|..:.|....|..:..|| :..|..:     ::.||.|  |.|.|   
Human     5 GVSLATAAAAAAAFGDEEKKMAAGKASGESEEASPSLTAEERE-----ALGGLDSRLFGFVRFHE 64

  Fly   243 -RFRSLSILGFTLLC--------------GLYCRLS----LLPRPSTAFSAADNPTAHESCFWTR 288
             ..|:.::||..:.|              ..:|:|.    ||.....|.||.....:.:|.:| :
Human    65 DGARTKALLGKAVRCYESLILKAEGKVESDFFCQLGHFNLLLEDYPKALSAYQRYYSLQSDYW-K 128

  Fly   289 TLTFLYLPVANFGILLWPQELSFDWGMEAVSRIRTLWDARNILTAGFYGSLVAILWKGSGLRSAA 353
            ...|||    ..|::.:... :|.|.::|                                    
Human   129 NAAFLY----GLGLVYFHYN-AFQWAIKA------------------------------------ 152

  Fly   354 SPMDFAEVANISLPLLRRLGGNSCHTWLGLTCDC---------HHQLSA----PSYRSASAI--- 402
                |.||..:.....|   ....|..|||....         |.||:.    |...|.:.|   
Human   153 ----FQEVLYVDPSFCR---AKEIHLRLGLMFKVNTDYESSLKHFQLALVDCNPCTLSNAEIQFH 210

  Fly   403 ----YSTSSKSKSASWTAAPILGTAFLVLPFLPASNLLFYVGFVMAERVLYLPSVGYCLLFGLGF 463
                |.|..|..||......:|.|          .||...|      :...|..:|         
Human   211 IAHLYETQRKYHSAKEAYEQLLQT----------ENLSAQV------KATVLQQLG--------- 250

  Fly   464 GHLWQRVNSSWRSRLMLLCGLALLLGVHGVRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSVL 528
                      |....:.|.|.......:.::..:::|:           ...|..::...||...
Human   251 ----------WMHHTVDLLGDKATKESYAIQYLQKSLE-----------ADPNSGQSWYFLGRCY 294

  Fly   529 SAQGRYEEAELTLRMTLGHRPTMADAHFNLGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLG 593
            |:.|:.::|.::.|.::......||...::||::|:|.....|:..:..|::|....|.|:::||
Human   295 SSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQAYICAVQLDHGHAAAWMDLG 359

  Fly   594 TSLISLGDHRQEAISVLRTGARLEG-SGVRDRGAHVEARYTCYLQLSVLYRSDGRLQDAAAALR- 656
            | |....:..|:||.......|.:. |......|.::     |||..:.....|.||:....|. 
Human   360 T-LYESCNQPQDAIKCYLNATRSKSCSNTSALAARIK-----YLQAQLCNLPQGSLQNKTKLLPS 418

  Fly   657 -ESLKALPL---LPQKQRAV 672
             |...:||:   |..:|.|:
Human   419 IEEAWSLPIPAELTSRQGAM 438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc1NP_995615.2 ArnT 11..>209 CDD:441412 7/24 (29%)
TMTC_DUF1736 271..340 CDD:462468 12/68 (18%)
PilF 501..585 CDD:442297 16/83 (19%)
TPR repeat 518..546 CDD:276809 6/27 (22%)
TPR repeat 551..581 CDD:276809 8/29 (28%)
LapB 556..838 CDD:442196 32/123 (26%)
TPR repeat 586..611 CDD:276809 9/24 (38%)
TPR repeat 634..660 CDD:276809 8/27 (30%)
TPR repeat 671..699 CDD:276809 1/2 (50%)
TPR repeat 704..735 CDD:276809
TPR repeat 740..768 CDD:276809
TPR repeat 773..803 CDD:276809
TPR repeat 808..836 CDD:276809
KDM6ANP_001406738.1 TPR repeat 93..121 CDD:276809 7/27 (26%)
BepA 98..233 CDD:443813 34/183 (19%)
TPR repeat 129..159 CDD:276809 10/74 (14%)
TPR repeat 164..194 CDD:276809 8/32 (25%)
LapB 171..443 CDD:442196 66/320 (21%)
TPR repeat 205..233 CDD:276809 6/27 (22%)
TPR repeat 243..278 CDD:276809 5/53 (9%)
TPR repeat 285..312 CDD:276809 6/26 (23%)
TPR repeat 317..347 CDD:276809 8/29 (28%)
TPR repeat 352..378 CDD:276809 9/26 (35%)
JmjC 1151..1215 CDD:214721
JmjC 1185..1293 CDD:396791
Blue background indicates that the domain is not in the aligned region.

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