Protein Alignment Tmtc1 and Ttc6

DIOPT Version :10

• Sequence 1: NP_995615.2
• Gene: Tmtc1 / 33455
• FlyBaseID: FBgn0051690
• Length: 859
• Species: Drosophila melanogaster
• Sequence 2: NP_001299573.1
• Gene: Ttc6 / 70846
• MGIID: 2684915
• Length: 1857
• Species: Mus musculus
• Alignment Length: 443
• Identity: 99/443 - (22%)
• Similarity: 164/443 - (37%)
• Gaps: 103/443 - (23%)

  Fly   493 VRTFRRNLDWRDEEQLFRSAISINPPKALGNLGSVLSAQGRYEEAELTLRMTLGHRPTMADAHFN 557
            ||.|::.|:..........|.|:: .:.|.|||.....:|.::.|..:....:...|..|:|.::
Mouse  1317 VRLFKKALELYTFSDKGPVATSVS-AECLYNLGLCYMEEGNFQMAFESFTKAVKANPEFAEAFYH 1380

  Fly   558 LGVVHQKQLNFSSAIPCFRRAIELRPQLAVAYLNLGTSLISLGDHRQEAI--------------- 607
            .|:...| ||..::|..|.||:.|.|:...|||: ..:...|.....:||
Mouse  1381 RGLCKVK-LNKQNSILDFNRALTLNPKHYQAYLS-RVAYYGLKGRYSKAILNCNEAIKLYPESVR 1443

  Fly   608 -----SVLRTGARLEGSGVRDRGAHVEA---RYTCYLQLSVLYRSDGRLQDAAAALRESLKALPL 664
                 .||:...|....|:.|....::.   .||.|...::.|...|..|   .|||:....| |
Mouse  1444 AYICRGVLKYYNRTYKLGITDLSTAIKMDKNNYTAYYNRALCYTKIGEHQ---MALRDYGIVL-L 1504

  Fly   665 LPQKQRAVLH--LRLGEILAELQDWNEA-EHQQRLAMQLQPEQGAAYVTYGQTLARNGSRLAEAE 726
            |...:...|:  :..|.|..||:.:..| |..::.|:     .....|:..|..|....|:.|.|
Mouse  1505 LDAGENIALNTLINRGLIYTELKQYGFALEDFKQAAL-----MSGTSVSLCQATATCHHRIKEFE 1564

  Fly   727 ---SWFKRALQLAPLEPSSHHHYAD--------FLE--QQERHHEALGLRLRAAALAPQDYTLQS 778
               .:|.||:::.|       ||.|        ::|  |::...:|....|:|..|.|      |
Mouse  1565 GAVEFFTRAIKINP-------HYVDAYIGRGNSYMEYSQEDAMIQAQKDFLKALHLDP------S 1616

  Fly   779 CVADALRL-LNRLAEAEL---WY------------------RKAVTLQ----------------- 804
            |:...:.| .|..|:.:.   |.                  |..|.||
Mouse  1617 CLKARISLGYNLQAQGKFQKAWIHFTVGIESNPKSYLAYEGRAVVCLQMSNYFAAMQDINCAIKI 1681

  Fly   805 PMAAHAHANLGAILQMRGLRKEAVACYHKALELQPGHAISRANLARMNVHKHE 857
            ...|....|.|.|.:..|.::.|:|.|..|:.|.|.::::..|...:.:|..:
Mouse  1682 NSTAEFLTNRGVIHEFMGQQQSAMADYQAAISLNPSYSLAYFNAGNIYLHHRQ 1734

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc1	NP_995615.2	ArnT	11..>209	CDD:441412
		TMTC_DUF1736	271..340	CDD:462468
		PilF	501..585	CDD:442297	21/83 (25%)
		TPR repeat	518..546	CDD:276809	6/27 (22%)
		TPR repeat	551..581	CDD:276809	10/29 (34%)
		LapB	556..838	CDD:442196	80/359 (22%)
		TPR repeat	586..611	CDD:276809	7/44 (16%)
		TPR repeat	634..660	CDD:276809	7/25 (28%)
		TPR repeat	671..699	CDD:276809	8/30 (27%)
		TPR repeat	704..735	CDD:276809	9/33 (27%)
		TPR repeat	740..768	CDD:276809	8/37 (22%)
		TPR repeat	773..803	CDD:276809	8/51 (16%)
		TPR repeat	808..836	CDD:276809	9/27 (33%)
Ttc6	NP_001299573.1	PTZ00436	<13..178	CDD:185616
		TPR repeat	889..917	CDD:276809
		PEP_TPR_lipo	896..1760	CDD:274350	99/443 (22%)
		TPR repeat	922..952	CDD:276809
		TPR repeat	957..984	CDD:276809
		TPR repeat	990..1017	CDD:276809
		TPR repeat	1023..1051	CDD:276809
		TPR repeat	1056..1086	CDD:276809
		TPR repeat	1162..1189	CDD:276809
		TPR repeat	1194..1224	CDD:276809
		TPR repeat	1229..1257	CDD:276809
		TPR repeat	1268..1292	CDD:276809
		TPR repeat	1299..1325	CDD:276809	3/7 (43%)
		TPR repeat	1341..1369	CDD:276809	6/27 (22%)
		TPR repeat	1374..1403	CDD:276809	10/29 (34%)
		TadD	<1398..1506	CDD:444034	26/112 (23%)
		TPR repeat	1408..1436	CDD:276809	6/28 (21%)
		TPR repeat	1441..1471	CDD:276809	5/29 (17%)
		TPR repeat	1476..1499	CDD:276809	9/25 (36%)
		TPR repeat	1515..1541	CDD:276809	6/25 (24%)
		TPR repeat	1546..1576	CDD:276809	9/29 (31%)
		TPR repeat	1581..1611	CDD:276809	5/29 (17%)
		TPR repeat	1619..1646	CDD:276809	4/26 (15%)
		TPR repeat	1651..1681	CDD:276809	4/29 (14%)
		TPR	1685..>1852	CDD:440225	13/50 (26%)
		TPR repeat	1685..1713	CDD:276809	9/27 (33%)
		TPR repeat	1718..1748	CDD:276809	2/17 (12%)
		TPR repeat	1753..1781	CDD:276809
		TPR repeat	1787..1810	CDD:276809
		TPR repeat	1821..1849	CDD:276809